LEADER 03094oam 2200457 450 001 9910298333503321 005 20190911103512.0 010 $a1-4614-8642-4 024 7 $a10.1007/978-1-4614-8642-8 035 $a(OCoLC)865509658 035 $a(MiFhGG)GVRL6XEK 035 $a(EXLCZ)993710000000073383 100 $a20140913d2014 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 04$aThe genetics of obesity /$fStruan F.A. Grant, editor 205 $a1st ed. 2014. 210 1$aNew York :$cSpringer,$d2014. 215 $a1 online resource (viii, 128 pages) $ccolor illustrations 225 0 $aGale eBooks 300 $aDescription based upon print version of record. 311 $a1-4614-8641-6 320 $aIncludes bibliographical references and index. 327 $aGenetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies -- Genetic Obesity Syndromes -- Genome-Wide Association Studies of Obesity -- Copy Number Variants and their Contribution to the Risk of Obesity -- Genetics of Childhood Obesity -- Genetic Pleiotropies of Obesity -- Functional Follow-up of Genetic Variants Using FTO as the Prime Example -- Index. 330 $aIn the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO),  has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity.   Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants. 606 $aObesity$xGenetic aspects 615 0$aObesity$xGenetic aspects. 676 $a599.935 676 $a599935 676 $a610 676 $a611.01816 702 $aGrant$b Struan F. A. 801 0$bMiFhGG 801 1$bMiFhGG 906 $aBOOK 912 $a9910298333503321 996 $aThe Genetics of Obesity$92502162 997 $aUNINA LEADER 04738nam 2200733Ia 450 001 9910958425603321 005 20251116152212.0 010 $a9786612081569 010 $a9780309165433 010 $a0309165431 010 $a9781282081567 010 $a128208156X 010 $a9780309547390 010 $a0309547393 035 $a(CKB)1000000000033495 035 $a(EBL)3377941 035 $a(SSID)ssj0000280076 035 $a(PQKBManifestationID)11241355 035 $a(PQKBTitleCode)TC0000280076 035 $a(PQKBWorkID)10286345 035 $a(PQKB)10444797 035 $a(MiAaPQ)EBC3377941 035 $a(Au-PeEL)EBL3377941 035 $a(CaPaEBR)ebr10080790 035 $a(OCoLC)923274470 035 $a(Perlego)4734271 035 $a(BIP)11498281 035 $a(EXLCZ)991000000000033495 100 $a20050125d2005 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGrowing up global $ethe changing transitions to adulthood in developing countries /$fPanel on Transitions to Adulthood in Developing Countries ; Cynthia B. Lloyd, editor ; Committee on Population [and] Board on Children, Youth, and Families, Division of Behavioral and Social Sciences and Education 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$dc2005 215 $a1 online resource (700 p.) 300 $aDescription based upon print version of record. 311 08$a9780309095280 311 08$a030909528X 320 $aIncludes bibliographical references and index. 327 $a""Front Matter""; ""Preface""; ""Contents""; ""Executive Summary""; ""PART I Introduction and Conceptual Framework""; ""1 Introduction""; ""2 Conceptual Framework""; ""PART II Preparation for Adult Roles""; ""3 Schooling""; ""4 Health""; ""PART III Transition to Adult Roles""; ""5 The Transition to Work""; ""6 The Transition to Citizenship""; ""7 The Transition to Marriage""; ""8 The Transition to Parenthood""; ""PART IV Conclusions""; ""9 The Way Forward""; ""References""; ""APPENDIXES""; ""APPENDIX A Coverage, Definitions, Methods, and Data"" 327 $a""APPENDIX B Contents The Changing Transitions to Adulthood in Developing Countries: Selected Studies""""APPENDIX C Biographical Sketches of Panel Members and Staff""; ""Index"" 330 $aThe challenges for young people making the transition to adulthood are greater today than ever before. Globalization, with its power to reach across national boundaries and into the smallest communities, carries with it the transformative power of new markets and new technology. At the same time, globalization brings with it new ideas and lifestyles that can conflict with traditional norms and values. And while the economic benefits are potentially enormous, the actual course of globalization has not been without its critics who charge that, to date, the gains have been very unevenly distributed, generating a new set of problems associated with rising inequality and social polarization. Regardless of how the globalization debate is resolved, it is clear that as broad global forces transform the world in which the next generation will live and work, the choices that today's young people make or others make on their behalf will facilitate or constrain their success as adults. Traditional expectations regarding future employment prospects and life experiences are no longer valid. Growing Up Global examines how the transition to adulthood is changing in developing countries, and what the implications of these changes might be for those responsible for designing youth policies and programs, in particular, those affecting adolescent reproductive health. The report sets forth a framework that identifies criteria for successful transitions in the context of contemporary global changes for five key adult roles: adult worker, citizen and community participant, spouse, parent, and household manager. 606 $aYoung adults$zDeveloping countries 606 $aYouth$zDeveloping countries 606 $aAdulthood$zDeveloping countries 606 $aSchool-to-work transition$zDeveloping countries 615 0$aYoung adults 615 0$aYouth 615 0$aAdulthood 615 0$aSchool-to-work transition 676 $a305.242/09172/4 701 $aLloyd$b Cynthia B.$f1943-$0146055 712 02$aNational Research Council (U.S.).$bCommittee on Population. 712 02$aNational Research Council (U.S.).$bBoard on Children, Youth, and Families. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910958425603321 996 $aGrowing up global$94355664 997 $aUNINA