LEADER 05883nam 2200745Ia 450 001 9910957776403321 005 20251116141802.0 010 $a9786610221608 010 $a9781280221606 010 $a1280221607 010 $a9780309557696 010 $a0309557690 010 $a9780585155395 010 $a0585155399 035 $a(CKB)111004366657398 035 $a(EBL)3377244 035 $a(SSID)ssj0000141451 035 $a(PQKBManifestationID)11151381 035 $a(PQKBTitleCode)TC0000141451 035 $a(PQKBWorkID)10079789 035 $a(PQKB)10400561 035 $a(MiAaPQ)EBC3377244 035 $a(Au-PeEL)EBL3377244 035 $a(CaPaEBR)ebr10068486 035 $a(OCoLC)923269214 035 $a(Perlego)4733840 035 $a(BIP)445784 035 $a(EXLCZ)99111004366657398 100 $a19810126d1987 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPharmacokinetics in risk assessment /$fSubcommittee on Disinfectants and Disinfectant By-Products, Safe Drinking Water Committee, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences, National Research Council 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1987 215 $a1 online resource (512 pages) 225 0 $aDrinking water and health ;$vv.8 311 0 $a9780309037754 311 0 $a0309037751 327 $a""Pharmacokinetics in Risk Assessment""; ""Copyright""; ""PREFACE""; ""Contents""; ""PART I INTRODUCTION: THE PROBLEM AND AN APPROACH ""; ""Risk Assessment: Historical Perspectives""; ""References""; ""Tissue Dosimetry in Risk Assessment, or What's the Problem Here Anyway?""; ""INTRODUCTION""; ""A DOSE OF WHAT?""; ""ISN'T THIS VOLUME ABOUT PHARMACOKINETICS?""; ""GENOTOXIC CARCINOGENS""; ""PARENT CHEMICAL""; ""STABLE METABOLITES""; ""REACTIVE, NONISOLATABLE METABOLITES""; ""INTERCALATING AGENTS""; ""EPIGENETIC CARCINOGENS""; ""SUMMARY""; ""References""; ""PART II MATHEMATICAL MODELING "" 327 $a""Modeling: An Introduction"" ""References""; ""Physiologically Based Pharmacokinetic Modeling""; ""INTRODUCTION""; ""BIOLOGICAL BASIS OF PHYSIOLOGICAL PHARMACOKINETICS""; ""DEVELOPMENT OF MODELS""; ""CHOICE OF COMPARTMENTS""; ""BASIC MASS BALANCES""; ""Mass Balance: Blood Pool""; ""Mass Balance: Tissue Region i""; ""SIMPLIFICATIONS OF MASS BALANCES""; ""Examples""; ""DISCUSSION""; ""FUTURE RESEARCH NEEDS""; ""References""; ""PART III GENERALIZATIONS AND EXTRAPOLATIONS ""; ""Allometry: Body Size Constraints in Animal Design""; ""INTRODUCTION""; ""SIZE, DESIGN, AND PHARMACOKINETICS"" 327 $a""Aerobic Energetics of Muscle In Vivo"" ""Conflict of Physiological and Chronological Time""; ""Species Extrapolations, Physiological Time, and Pharmacokinetics""; ""CONCLUSIONS""; ""SUMMARY""; ""References""; ""Prediction of In Vivo Parameters of Drug Metabolism and Distribution from In Vitro Studies""; ""IN VITRO PREDICTION OF IN VIVO DRUG METABOLISM""; ""IN VITRO PREDICTION OF IN VIVO DRUG BINDING AND DISTRIBUTION""; ""CONCLUSION""; ""References""; ""Dose, Species, and Route Extrapolation: General Aspects""; ""DIFFERENT PROBLEMS AND OBJECTIVES, DIFFERENT MODELS""; ""Different Mechanisms"" 327 $a""GENERAL PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELS"" ""Simplification of Models""; ""Rates of Formation of Complexes""; ""Diffusional Barriers and Modified Fick's Law""; ""Simple PB-PK Models""; ""Basic Parameters fu and R""; ""Nonlinear Kinetics and Lost Concepts""; ""INTERFACE BETWEEN PB-PK MODELS AND CLEARANCES""; ""Organ Availabilities (F), Extraction Ratios (E), and Clearances (CL)""; ""Physiologically Based Linear Compartmental Pharmacokinetic Models""; ""Validity of the Assumption of Virtual Steady State""; ""Calculation of Other Compartmental Model Parameters"" 327 $a""Approximations of Terminal Half-Lives"" ""Approximate Time Required to Approach Steady State""; ""LINEAR PHARMACOKINETIC SYSTEMS""; ""Total Body Clearance""; ""Importance of the Unbound Concentration of Substances""; ""Classification of Organs; Routes of Administration""; ""Non-First-Pass, Nonelimination Organs""; ""Range of Maximum and Minimum Unbound Concentrations in Nonelimination Organs and Repetitive Administration""; ""Non-First-Pass, Elimination Organs""; ""FIRST-PASS, NONELIMINATION ORGANS""; ""First-Pass, Elimination Organs""; ""ROUTE-TO-ROUTE EXTRAPOLATION""; ""Lungs and Skin Administration"" 330 $aPharmacokinetics, the study of the movement of chemicals within the body, is a vital tool in assessing the risk of exposure to environmental chemicals. This book--a collection of papers authored by experts in academia, industry, and government--reviews the progress of the risk-assessment process and discusses the role of pharmacokinetic principles in evaluating risk. In addition, the authors discuss software packages used to analyze data and to build models simulating biological phenomena. A summary chapter provides a view of trends in pharmacokinetic modeling and notes some prospective fields of study. 606 $aDrinking water$xContamination$zUnited States 606 $aDrinking water$xContamination 606 $aDrinking water$xHealth aspects$zUnited States 606 $aDrinking water$xHealth aspects 606 $aWater$xPollution$xToxicology 615 0$aDrinking water$xContamination 615 0$aDrinking water$xContamination. 615 0$aDrinking water$xHealth aspects 615 0$aDrinking water$xHealth aspects. 615 0$aWater$xPollution$xToxicology. 676 $a333.9122 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910957776403321 996 $aPharmacokinetics in risk assessment$94351719 997 $aUNINA