LEADER 05440nam 2200685Ia 450 001 9910956907403321 005 20200520144314.0 010 $a9781118619278 010 $a1118619277 010 $a9781118619230 010 $a1118619234 035 $a(CKB)2670000000400812 035 $a(EBL)1319494 035 $a(OCoLC)854521190 035 $a(SSID)ssj0001101554 035 $a(PQKBManifestationID)11650165 035 $a(PQKBTitleCode)TC0001101554 035 $a(PQKBWorkID)11067988 035 $a(PQKB)11043021 035 $a(MiAaPQ)EBC1319494 035 $a(Au-PeEL)EBL1319494 035 $a(CaPaEBR)ebr10738086 035 $a(CaONFJC)MIL527780 035 $a(Perlego)1003077 035 $a(EXLCZ)992670000000400812 100 $a20120904d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aUpstream industrial biotechnology /$fedited by Michael C. Flickinger 205 $a1st ed. 210 $aHoboken, New Jersey $cJohn Wiley & Sons Inc.$dc2013 215 $a1 online resource (1838 p.) 300 $aDescription based upon print version of record. 311 08$a9781118131237 311 08$a1118131231 320 $aIncludes bibliographical references and index. 327 $aUPSTREAM INDUSTRIAL BIOTECHNOLOGY; CONTENTS; 27 Animal Cell Culture, Effects of Osmolality and Temperature; PREFACE; CONTRIBUTORS; PART I INTRODUCTION; PART II INDUSTRIAL CELL GROWTH AND GENE EXPRESSION SYSTEMS; 1 Animal Cells, Suspension Culture; 1.1 INTRODUCTION; 1.2 TYPES USED FOR LARGE-SCALE PRODUCTION IN SUSPENSION CULTURE; 1.3 SUSPENSION CULTURE REACTORS; 1.4 OPERATING MODES FOR REACTORS; 1.5 PROCESS MONITORING AND CONTROL; 1.6 CULTURE MEDIA FOR SUSPENSION CULTURE; 1.7 CONCLUSIONS; REFERENCES; 2 Baculovirus Expression Systems; 2.1 INTRODUCTION; 2.2 BACULOVIRUS STRUCTURE AND REPLICATION 327 $a2.3 PRODUCTION OF RECOMBINANT BACULOVIRUSES2.4 BACULOVIRUS TRANSFER VECTORS; 2.5 MODIFYING THE BACULOVIRUS GENOME TO IMPROVE PROTEIN PRODUCTION; 2.6 INSECT CELL CULTURE; 2.7 BACULOVIRUSES FOR GENE EXPRESSION IN MAMMALIAN CELLS; 2.8 CONCLUSION; REFERENCES; 3 Baculovirus Kinetics, Insect Culture; 3.1 HISTORY AND CHALLENGE; 3.2 BACULOVIRUS; 3.3 CELL YIELD CONCEPT; 3.4 KINETIC MODEL OF VIRAL INFECTION: SYNCHRONOUS INFECTION; 3.5 KINETIC MODEL OF VIRAL INFECTION: ASYNCHRONOUS INFECTION; REFERENCES; 4 Cell Culture, Aseptic Techniques; 4.1 INTRODUCTION; 4.2 ASEPTIC TECHNIQUE: GENERAL CONSIDERATIONS 327 $a4.3 ASEPTIC TECHNIQUE: BASIC PROCEDURES4.4 HEPA FILTRATION; 4.5 HOODS AND CABINETS EMPLOYING HEPA FILTRATION; 4.6 WORKING WITHIN UNIDIRECTIONAL AIRFLOW CABINETS AND MICROBIOLOGICAL SAFETY CABINETS; 4.7 TESTING OF CLASS I AND CLASS II MICROBIOLOGICAL SAFETY CABINETS; 4.8 CLEANROOMS FOR CELL CULTURE USE; REFERENCES; 5 Cell Cycle in Bioprocesses; 5.1 INTRODUCTION; 5.2 THE CELL CYCLE; 5.3 METHODS FOR DESCRIBING THE CELLCYCLE; 5.4 IMPORTANCE OF THE CELL CYCLE IN PROCESS BIOTECHNOLOGY; REFERENCES; 6 Cell Growth and Protein Expression Kinetics; 6.1 INTRODUCTION; 6.2 BATCH CULTURE KINETICS 327 $a6.3 CONTINUOUS CULTURE KINETICS6.4 FED-BATCH AND PERFUSION CULTURES; 6.5 CONCLUSIONS; NOMENCLATURE; REFERENCES; 7 Cell Viability Measurement; 7.1 INTRODUCTION; 7.2 PERMEABILITY ASSAYS; 7.3 FUNCTIONAL ASSAYS; 7.4 FLOW CYTOMETRY; 7.5 PHYSICAL METHODS; REFERENCES; 8 Contamination Detection in Animal Cell Culture; 8.1 INTRODUCTION; 8.2 HISTORICAL PERSPECTIVES; 8.3 REGULATORY ISSUES; 8.4 MANUFACTURING AND SAFETY TESTING STANDARDS; 8.5 EXAMPLES OF VIRAL CONTAMINANTS; 8.6 DETECTION OF VIRAL CONTAMINANTS IN CELL LINES; 8.7 TESTING RAW MATERIALS; 8.8 DETECTION OF MYCOPLASMAS; 8.9 BACTERIA AND FUNGI 327 $a8.10 OXYGEN UPTAKE RATE8.11 ENDOTOXIN DETECTION; 8.12 STATISTICAL ANALYSIS; 8.13 DETECTION OF PRIONS; 8.14 SUMMARY; REFERENCES; 9 Culture Collections and Biological Resource Centers (BRCs); 9.1 INTRODUCTION; 9.2 CULTURE COLLECTION FUNDING; 9.3 OPERATION; 9.4 QUALITY MANAGEMENT; 9.5 SERVICES; 9.6 SUMMARY; REFERENCES; FURTHER READING; 10 Culture Preservation; 10.1 INTRODUCTION; 10.2 CULTURE AND PRESERVATION OF BACTERIA; 10.3 CULTURE AND PRESERVATION OF FUNGI AND YEAST; 10.4 CULTURE AND PRESERVATION OF CELL CULTURES; REFERENCES 327 $a11 Expression and Secretion of Heterologous Proteins, Bacillus and Other Gram-Positive Bacteria 330 $aBiotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive reso 606 $aBiotechnology 606 $aBiotechnology industries 615 0$aBiotechnology. 615 0$aBiotechnology industries. 676 $a660.6 686 $aSCI010000$2bisacsh 701 $aFlickinger$b Michael C$016579 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910956907403321 996 $aUpstream industrial biotechnology$94351579 997 $aUNINA