LEADER 03906nam 2200601 a 450 001 9910956653303321 005 20251117090905.0 010 $a1-61324-564-5 035 $a(CKB)2550000000044963 035 $a(EBL)3019785 035 $a(SSID)ssj0000522476 035 $a(PQKBManifestationID)12251554 035 $a(PQKBTitleCode)TC0000522476 035 $a(PQKBWorkID)10527852 035 $a(PQKB)11727553 035 $a(MiAaPQ)EBC3019785 035 $a(Au-PeEL)EBL3019785 035 $a(CaPaEBR)ebr10671350 035 $a(OCoLC)923661913 035 $a(BIP)26710843 035 $a(EXLCZ)992550000000044963 100 $a20090128d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aExperimental leukemia $ehistory, biology and genetics /$fTaketoshi Sugiyama 205 $a1st ed. 210 $aNew York $cNova Science Publishers$dc2009 215 $a1 online resource (476 p.) 300 $aDescription based upon print version of record. 311 08$a1-60021-497-5 320 $aIncludes bibliographical references (p. [339]-443) and index. 327 $aBackgrounds of experimental leukemia research -- Early history -- Avian sarcoma and leukosis viruses -- Murine leukemia and sarcoma viruses -- Chemical and radiation related leukemia -- Cytokines and cell differentiation -- Up-to-date problems in experimental leukemia. 330 $aThe world of experimental leukaemia research is a miniature of cancer research. Cancer research started from experimental leukaemia/sarcoma research of Ellermann and Bang and Peyton Rous in early 1900s. Experimental leukaemia includes most of important elements of cancer research; both viral and chemical carcinogenesis; most of important oncogenes and suppresser genes and the related cell biology. The author has added only a few sections such as skin carcinogenesis done by Yamagiwa and Berenblum and DNA viruses from outside of experimental leukaemia. By doing this, this book covers most of important topics of modern oncology, except researches done on human cancers. In this book, the author has arranged the chapters to contrast the pioneer works by Peyton Rous, Jacob Furth, and Ludwik Gross, etc, done more than half a century ago and the recent works by molecular biologists. Although the former pathologists provided various experimental materials, faced to severe criticism by contemporary researchers and they had tough hearts to cope with them, molecular biologists solved questions on these materials step by step by disclosing the invisible molecular events as a visible charts, molecular diagrams, or 3-D models just as magicians do. Experimental leukaemia has always afforded the key materials for solution of cancer. In experimental leukaemia, mutations and genetic recombination play an important role. They include ras gene mutations, insertional mutagenesis and gene transduction by retroviruses, recombination among retroviruses, and chromosome translocations. Most of them occur in highly specific genomic sites. However, the reason for the specificity in target sites remained obscure. The author was especially interested in the common target genomic sites for chemical carcinogens and retroviruses. Therefore the common pathway for retroviruses and chemicals became one of the main topics of this book. 606 $aLeukemia 606 $aLeukemia$xResearch 606 $aLeukemia in animals 606 $aOncology, Experimental 615 0$aLeukemia. 615 0$aLeukemia$xResearch. 615 0$aLeukemia in animals. 615 0$aOncology, Experimental. 676 $a616.99/419 700 $aSugiyama$b Taketoshi$01862221 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910956653303321 996 $aExperimental leukemia$94468466 997 $aUNINA