LEADER 05294nam 2200685 a 450 001 9910956498303321 005 20251017110106.0 010 $a0-309-16232-7 010 $a1-282-88562-6 010 $a9786612885624 010 $a0-309-11989-8 035 $a(CKB)2560000000068405 035 $a(EBL)3378674 035 $a(SSID)ssj0000441595 035 $a(PQKBManifestationID)11290757 035 $a(PQKBTitleCode)TC0000441595 035 $a(PQKBWorkID)10406861 035 $a(PQKB)10698824 035 $a(MiAaPQ)EBC3378674 035 $a(Au-PeEL)EBL3378674 035 $a(CaPaEBR)ebr10425163 035 $a(CaONFJC)MIL288562 035 $a(OCoLC)696782506 035 $a(DNLM)1544112 035 $a(EXLCZ)992560000000068405 100 $a20101202d2010 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRedesigning the clinical effectiveness research paradigm $einnovation and practice-based approaches : workshop summary /$fLeighAnne Olsen and J. Michael McGinnis, editors ; Institute of Medicine of the National Academies 205 $a1st ed. 210 $aWashington, D.C. $cNational Academies Press$d2010 215 $a1 online resource (443 p.) 225 1 $aThe learning healthcare system series 300 $aDescription based upon print version of record. 311 08$a0-309-11988-X 320 $aIncludes bibliographical references. 327 $a""Front Matter""; ""Reviewers""; ""Charter And Vision Statement""; ""Foreword""; ""Preface""; ""Contents""; ""Summary""; ""1 Evidence Development for Healthcare Decisions: Improving Timeliness, Reliability, and Efficiency""; ""2 Cases in Point: Learning from Experience""; ""3 Taking Advantage of New Tools and Techniques""; ""4 Organizing and Improving Data Utility""; ""5 Moving to the Next Generation of Studies""; ""6 Aligning Policy with Research Opportunities""; ""7 Organizing the Research Community for Change""; ""Appendixes""; ""Appendix A: Workshop Agenda"" 327 $a""Appendix B: Biographical Sketches of Workshop Participants""""Appendix C: Workshop Attendee List"" 330 $a"Recent scientific and technological advances have accelerated our understanding of the causes of disease development and progression, and resulted in innovative treatments and therapies. Ongoing work to elucidate the effects of individual genetic variation on patient outcomes suggests the rapid pace of discovery in the biomedical sciences will only accelerate. However, these advances belie an important and increasing shortfall between the expansion in therapy and treatment options and knowledge about how these interventions might be applied appropriately to individual patients. The impressive gains made in Americans' health over the past decades provide only a preview of what might be possible when data on treatment effects and patient outcomes are systematically captured and used to evaluate their effectiveness. Needed for progress are advances as dramatic as those experienced in biomedicine in our approach to assessing clinical effectiveness. In the emerging era of tailored treatments and rapidly evolving practice, ensuring the translation of scientific discovery into improved health outcomes requires a new approach to clinical evaluation. A paradigm that supports a continual learning process about what works best for individual patients will not only take advantage of the rigor of trials, but also incorporate other methods that might bring insights relevant to clinical care and endeavor to match the right method to the question at hand. The Institute of Medicine Roundtable on Value & Science-Driven Health Care's vision for a learning healthcare system, in which evidence is applied and generated as a natural course of care, is premised on the development of a research capacity that is structured to provide timely and accurate evidence relevant to the clinical decisions faced by patients and providers. As part of the Roundtable's Learning Healthcare System series of workshops, clinical researchers, academics, and policy makers gathered for the workshop Redesigning the Clinical Effectiveness Research Paradigm: Innovation and Practice-Based Approaches. Participants explored cutting-edge research designs and methods and discussed strategies for development of a research paradigm to better accommodate the diverse array of emerging data resources, study designs, tools, and techniques. Presentations and discussions are summarized in this volume."--Publisher's description. 410 0$aLearning healthcare system series. 606 $aMedical care$xResearch$vCongresses 606 $aMedical care$xEvaluation$vCongresses 606 $aMedical care$xQuality$zUnited States$vCongresses 615 0$aMedical care$xResearch 615 0$aMedical care$xEvaluation 615 0$aMedical care$xQuality 676 $a362.1 701 $aOlsen$b LeighAnne$01807706 701 $aMcGinnis$b J. Michael$01805133 712 02$aNational Academies Press (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910956498303321 996 $aRedesigning the clinical effectiveness research paradigm$94446167 997 $aUNINA