LEADER 05262nam 2200433z- 450 001 9910220049603321 005 20210211 035 $a(CKB)3800000000216281 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53847 035 $a(oapen)doab53847 035 $a(EXLCZ)993800000000216281 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation 210 $cFrontiers Media SA$d2017 215 $a1 online resource (151 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-104-6 330 $aEukaryotic cells contain distinct membrane-bound organelles, which compartmentalise cellular proteins to fulfil a variety of vital functions. Many organelles have long been regarded as isolated and static entities (e.g., peroxisomes, mitochondria, lipid droplets), but it is now evident that they display dynamic changes, interact with each other, share certain proteins and show metabolic cooperation and cross-talk. Despite great advances in the identification and characterisation of essential components and molecular mechanisms associated with the biogenesis and function of organelles, information on how organelles interact and are incorporated into metabolic pathways and signaling networks is just beginning to emerge. Organelle cooperation requires sophisticated targeting systems which regulate the proper distribution of shared proteins to more than one organelle. Organelle motility and membrane remodeling support organelle interaction and contact. This contact can be mediated by membrane proteins residing on different organelles which can serve as molecular tethers to physically link different organelles together. They can also contribute to the exchange of metabolites and ions, or act in the assembly of signaling platforms. In this regard organelle communication events have been associated with important cellular functions such as apoptosis, antiviral defense, organelle division/biogenesis, ROS metabolism and signaling, and various metabolic pathways such as breakdown of fatty acids or cholesterol biosynthesis. In this research topic we will focus on recent novel findings on the underlying molecular mechanisms and physiological significance of organelle interaction and cooperation with a particular focus on mitochondria, peroxisomes, endoplasmic reticulum, lysosomes and lipid droplets and their impact on the regulation of cellular homeostasis. Our understanding of how organelles physically interact and use cellular signaling systems to coordinate functional networks between each other is still in its infancy. Nevertheless recent discoveries of defined membrane structures such as the mitochondria-ER associated membranes (MAM) are revealing how membrane domains enriched in specific proteins transmit signals across organelle boundaries, allowing one organelle to influence the function of another. In addition to its role as a mediator between mitochondria and the ER, contacts between the MAM and peroxisomes contribute to antiviral signaling, and specialised regions of the ER are supposed to initiate peroxisome biogenesis, whereas intimate contacts between peroxisomes, lipid droplets and the ER mediate lipid metabolism. In line with these observations it is tempting to speculate that further physical contact sites between other organelles exist. Alternatively, novel regulated vesicle trafficking pathways between organelles (e.g., mitochondria to peroxisomes or lysosomes) have been discovered implying another mode of organelle communication. Identifying the key molecular players of such specialised membrane structures will be a prerequisite to understand how organelle communication is physically accomplished and will lead to the identification of new regulatory networks. In addition to the direct transmission of interorganellar information, cytosolic messenger systems (e.g., kinase/phosphatase systems or redox signaling) may contribute to the coordination of organelle functions. This research topic will integrate new findings from both modes of communication and will provide new perspectives for the functional significance of cross-talk among organelles. We would like to thank all the researchers who contributed their valuable work to this research topic. Furthermore, we are grateful to the reviewers and Associate Editors who contributed valuable comments and positive criticism to improve the contributions. 606 $aBiology, life sciences$2bicssc 610 $aEndoplasmic Reticulum 610 $aIntracellular signaling 610 $alipid droplet 610 $amembrane contact sites 610 $aMitochondria 610 $aOrganelle communication 610 $aorganelle dynamics 610 $aPeroxisomes 615 7$aBiology, life sciences 700 $aMarkus Islinger$4auth$01328837 702 $aMichael Schrader$4auth 906 $aBOOK 912 $a9910220049603321 996 $aMolecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation$93039015 997 $aUNINA LEADER 05345nam 2200673Ia 450 001 9910955676503321 005 20251117014445.0 010 $a1-282-88935-4 010 $a9786612889356 010 $a1-118-00790-5 035 $a(CKB)2670000000054900 035 $a(EBL)706730 035 $a(OCoLC)696604397 035 $a(SSID)ssj0000439469 035 $a(PQKBManifestationID)11317973 035 $a(PQKBTitleCode)TC0000439469 035 $a(PQKBWorkID)10468783 035 $a(PQKB)10043616 035 $a(MiAaPQ)EBC706730 035 $a(CaSebORM)9781118007921 035 $a(Au-PeEL)EBL706730 035 $a(CaPaEBR)ebr10524029 035 $a(CaONFJC)MIL288935 035 $a(EXLCZ)992670000000054900 100 $a20100903d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMCTS $eMicrosoft sharepoint 2010 configuration study guide : [Exam 70-667] /$fJames Pyles 205 $a1st ed. 210 $aIndianapolis $cWiley Technology Pub.$dc2011 215 $a1 online resource (676 p.) 225 1 $aSybex serious skills 300 $aDescription based upon print version of record. 311 08$a0-470-62701-8 327 $aMCTS; Introduction; Chapter 1: What's New in Microsoft SharePoint 2010; New Requirements Overview; Requirements by Environment; What's New and Different with SharePoint Server 2010?; Summary; Exam Essential; Review Questions; Answers to Review Questions; Chapter 2: Planning and Deploying a SharePoint 2010 Installation and Upgrade; Planning the SharePoint Server 2010 Environment; SharePoint Server 2010: Deploying and Upgrading; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 3: Configuring SharePoint Farm Environments; Server Farm Configuration Overview 327 $aSummaryExam Essentials; Review Questions; Answers to Review Questions; Chapter 4: Configuring Service Applications; Service Applications Configuration Overview; Service Application Management; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 5: Configuring Indexing and Search; Enterprise Search Overview; Managing Enterprise Search from General Application Settings; Managing the Enterprise Search Topology; Managing FAST Search for SharePoint; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 6: Managing Operational Settings 327 $aManaging MetadataManaging Database Operations for SharePoint; Managing Business Data Connectivity; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 7: Managing User Accounts and Roles; Managing the User Profile Service; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 8: Managing Authentication Providers and Permissions; Managing Authentication Methods; Managing Custom Permissions; Errors; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 9: Managing Web Applications and Host Sites 327 $aManaging Business IntelligenceAdministering PerformancePoint; Administering Excel Services; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 10: Managing Site Collections; Site Collections Administration; Web Content Management; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 11: Deploying and Managing Applications and Solutions; Sandbox Administration; Managing the State Service; Workflow Administration; Administering InfoPath Forms; Summary; Exam Essentials; Review Questions; Answers to Review Questions 327 $aChapter 12: Backing Up and Restoring SharePointConfiguring Permissions for Backup and Recovery; Managing Backup Operations; Managing Restore Operations; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 13: Monitoring the SharePoint Environment; Understanding Monitoring Tools; Configuring Monitoring; Reviewing Logs and Reports; Summary; Exam Essentials; Review Questions; Answers to Review Questions; Chapter 14: Optimizing SharePoint; SharePoint Optimization; Configuring Mobile Administration; Summary; Exam Essentials; Review Questions 327 $aAnswers to Review Questions 330 $aA Sybex study guide for the new SharePoint Server 2010 Configuration exam SharePoint holds 55 percent of the collaboration and content management market, with many more companies indicating they plan to join the fold. IT professionals interested in enhancing their marketability with the new Microsoft Certified Technology Specialist: Microsoft SharePoint Server 2010 Configuring exam will find this guide may be their only alternative to costly classroom training.Microsoft SharePoint claims over half the market for collaboration and content management software; IT professionals w 410 0$aSerious skills. 517 3 $aMicrosoft sharepoint 2010 configuration study guide (70-667) 606 $aIntranets (Computer networks) 606 $aWeb servers 615 0$aIntranets (Computer networks) 615 0$aWeb servers. 676 $a004.6/82 700 $aPyles$b James$01856788 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910955676503321 996 $aMCTS$94457043 997 $aUNINA