LEADER 04005nam 2200673Ia 450 001 9911019307803321 005 20200520144314.0 010 $a9786610411177 010 $a9781280411175 010 $a1280411171 010 $a9780470035009 010 $a0470035005 010 $a9780470034996 010 $a0470034998 035 $a(CKB)1000000000357399 035 $a(EBL)255723 035 $a(SSID)ssj0000245851 035 $a(PQKBManifestationID)11211418 035 $a(PQKBTitleCode)TC0000245851 035 $a(PQKBWorkID)10181220 035 $a(PQKB)10013973 035 $a(MiAaPQ)EBC255723 035 $a(OCoLC)86221676 035 $a(Perlego)2775030 035 $a(EXLCZ)991000000000357399 100 $a20050331d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSignalling pathways in acute oxygen sensing 210 $aChichester, UK ;$aHoboken, NJ $cJohn Wiley$d2006 215 $a1 online resource (302 p.) 225 1 $aNovartis Foundation symposium ;$v272 300 $aDescription based upon print version of record. 311 08$a9780470014578 311 08$a0470014571 320 $aIncludes bibliographical references and indexes. 327 $aCover; Contents; Chair's introduction; Regulation of gene expression by HIF-1; DISCUSSION; Regulation of HIF: prolyl hydroxylases; DISCUSSION; General discussion I; Regulation of HIF: asparaginyl hydroxylation; DISCUSSION; Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells; DISCUSSION; The role of TASK-like K+ channels in oxygen sensing in the carotid body; DISCUSSION; Reactive oxygen species facilitate oxygen sensing; DISCUSSION; Oxygen sensing in neuroepithelial and adrenal chromaffin cells; DISCUSSION 327 $aHypoxic regulation of Ca2+ signalling in astrocytes and endothelial cellsDISCUSSION; General discussion II; Functional proteomics of BK potassium channels: defining the acute oxygen sensor; DISCUSSION; A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system; DISCUSSION; Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction; DISCUSSION; Hypoxic pulmonary vasoconstriction-triggered by an increase in reactive oxygen species?; DISCUSSION; General discussion III 327 $aThe role of twin pore domain and other K+ channels in hypoxicpulmonary vasoconstrictionDISCUSSION; AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells; DISCUSSION; Role of capacitative Ca2+ entry but not Na+/Ca2+ exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries; DISCUSSION; Final general discussion; Index of contributors; Subject index 330 $aOxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mech 410 0$aNovartis Foundation symposium ;$v272. 606 $aOxygen in the body 606 $aOxygen 615 0$aOxygen in the body. 615 0$aOxygen. 676 $a572.53 676 $a573.1536 712 02$aNovartis Foundation. 712 12$aSymposium on Signalling Pathways in Acute Oxygen Sensing 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9911019307803321 996 $aSignalling pathways in acute oxygen sensing$94421697 997 $aUNINA LEADER 03819nam 2200697Ia 450 001 9910955667703321 005 20251116175317.0 010 $a1-134-73300-3 010 $a0-203-37720-6 010 $a0-203-36044-3 010 $a1-134-73301-1 010 $a1-280-06194-4 010 $a9786610061945 024 7 $a10.4324/9780203360446 035 $a(CKB)1000000000249329 035 $a(EBL)179964 035 $a(OCoLC)259498741 035 $a(SSID)ssj0000278834 035 $a(PQKBManifestationID)11912359 035 $a(PQKBTitleCode)TC0000278834 035 $a(PQKBWorkID)10258224 035 $a(PQKB)11068485 035 $a(MiAaPQ)EBC179964 035 $a(Au-PeEL)EBL179964 035 $a(CaPaEBR)ebr10097434 035 $a(CaONFJC)MIL6194 035 $a(OCoLC)56620848 035 $a(EXLCZ)991000000000249329 100 $a19971008d1998 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrawing on difference $eart therapy with people who have learning difficulties /$fedited by Mair Rees 205 $a1st ed. 210 $aLondon ;$aNew York $cRoutledge$d1998 215 $a1 online resource (284 p.) 300 $aDescription based upon print version of record. 311 08$a0-415-15480-4 311 08$a0-415-15479-0 320 $aIncludes bibliographical references and index. 327 $aBook Cover; Title; Contents; List of illustrations; List of contributors; Acknowledgements; Introduction; A personal journey; Frames of reference: Some operational and contextual issues influencing the practice of art therapy with people who have learning difficulties; It's a mystery: Accounts of an art therapy group for people with learning difficulties; On the edge: Art therapy for people with learning difficulties and disordered personalities; Lost in space: The relevance of art therapy with clients who have autism or autistic features 327 $aHumpty Dumpty's shell: Working with autistic defence mechanisms in art therapyRape!: The violation of integrity and will; Is art therapy?: Some issues arising in working with children with severe learning difficulties; Learning to say 'goodbye': Loss and bereavement in learning difficulties and the role of art therapy; Journey in joint working: Some reflections on an experience of arts therapies collaboration; Chances for change: Counselling people with learning difficulties; There is light at the end of the tunnel: Ways to good 'clinical effectiveness research' 327 $aClinical supervision in art therapy: Is it really 'super!'?Index 330 $aThis book reveals how art therapy can support and validate the emotional and mental health needs of people with learning difficulties. Case studies present work with adults and children with differing degrees of difficulty such as personality disorder, autism or severe learning difficulties and discuss the needs of people with learning difficulties who have experienced traumas such as rape or bereavement. Particular emphasis is placed on service evaluation and standards and on the client's personal experience.Contributors discuss practical, professional and political issues such as:- * 606 $aPeople with mental disabilities$xRehabilitation 606 $aArt therapy 606 $aPeople with mental disabilities$xMental health 615 0$aPeople with mental disabilities$xRehabilitation. 615 0$aArt therapy. 615 0$aPeople with mental disabilities$xMental health. 676 $a616.85/889065156 701 $aRees$b Mair$f1960-$01072695 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910955667703321 996 $aDrawing on difference$94493367 997 $aUNINA