LEADER 05598nam 2200733Ia 450 001 9910953849203321 005 20251017110112.0 010 $a9786610214938 010 $a9781280214936 010 $a1280214937 010 $a9780309564229 010 $a0309564220 010 $a9780585144160 010 $a0585144168 035 $a(CKB)111004366657420 035 $a(OCoLC)70772912 035 $a(CaPaEBR)ebrary10056870 035 $a(SSID)ssj0000266003 035 $a(PQKBManifestationID)11204552 035 $a(PQKBTitleCode)TC0000266003 035 $a(PQKBWorkID)10301028 035 $a(PQKB)11279606 035 $a(MiAaPQ)EBC3376595 035 $a(Au-PeEL)EBL3376595 035 $a(CaPaEBR)ebr10056870 035 $a(CaONFJC)MIL21493 035 $a(OCoLC)814279842 035 $a(Perlego)4733899 035 $a(DNLM)665753 035 $a(BIP)1672171 035 $a(EXLCZ)99111004366657420 100 $a20040925d1988 my 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aUse of laboratory animals in biomedical and behavioral research /$fCommittee on the Use of Laboratory Animals in Biomedical and Behavioral Research, Commission on Life Sciences, National Research Council [and] Institute of Medicine 205 $a1st ed. 210 $aWashington, D.C. $cNational Academy Press$d1988 215 $a1 online resource (112 p.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a9780309038393 311 08$a0309038391 320 $aIncludes bibliographical references and index. 327 $aUse of Laboratory Animals in Biomedical and Behavioral Research -- Copyright -- Contents -- Preface -- Executive Summary -- PATTERNS OF ANIMAL USE -- BENEFITS DERIVED FROM THE USE OF ANIMALS -- ALTERNATIVE METHODS IN BIOMEDICAL AND BEHAVIORAL RESEARCH -- REGULATORY ISSUES -- USE OF POUND ANIMALS -- 1 Introduction -- HISTORICAL BACKGROUND -- Use of Animals in Research -- Concerns Over Animal Use -- PRESENT SITUATION -- 2 Patterns of Animal Use -- NUMBERS OF ANIMALS USED -- USE OF ANIMALS IN RESEARCH BY THE FEDERAL GOVERNMENT -- USE OF ANIMALS IN EDUCATION -- USE OF ANIMALS IN TESTING -- NEW TECHNOLOGIES AND FUTURE LABORATORY USE OF ANIMALS -- SUMMARY -- 3 Benefits Derived from the Use of Animals -- POLIO -- ACQUIRED IMMUNE DEFICIENCY SYNDROME -- TRANSPLANTATION -- CARDIOVASCULAR-RENAL SYSTEMS -- NERVOUS SYSTEM -- Movement and Function -- Behavior -- Postnatal Development of the Visual Cortex and the Influence of Environment -- Memory -- Pain -- OTHER BENEFITS FOR HUMANS -- BENEFITS FOR ANIMALS -- SUMMARY -- 4 Alternative Methods in Biomedical and Behavioral Research -- RELATIONSHIPS AMONG LIFE FORMS -- ANIMAL MODELS -- ALTERNATIVES TO MAMMALS -- Nonmammalian Vertebrates -- Invertebrates -- Microorganism -- Cell and Tissue Cultures -- Human Tissues -- In Vitro Systems and Mathematical Models -- Refinements -- ALTERNATIVE METHODS IN TESTING -- SUMMARY -- 5 Regulatory Issues -- APPROACHES TO REGULATION -- FEDERAL REGULATIONS -- Legislation Passed in 1985: The Health Research Extension Act and the Food Security Act -- GOVERNMENT POLICY STATEMENTS -- Guide for the Care and Use of Laboratory Animals -- Public Health Service Policy on Humane Care and Use of Laboratory Animals -- Good Laboratory Practices Regulations -- STATE REGULATIONS -- APPROACHES TO REGULATION -- Granting Agency Approach to Regulation -- Self-Regulation -- EFFECTS OF REGULATIONS. 327 $aEffects on Training and Education -- Effects on Experimental Results -- Effects on Direct Expense of Research -- Effects on the Animals -- ENFORCEMENT AND ENACTMENT OF REGULATIONS AND LAWS -- 6 Use of Pound Animals -- SUPPLY OF POUND ANIMALS -- REGULATIONS -- SCIENTIFIC CONSIDERATIONS -- BENEFITS -- COST CONSIDERATIONS -- CONCERNS FOR THE ANIMALS -- 7 Conclusions and Recommendations -- RECOMMENDATIONS -- References -- Individual Statements by Members of the Committee on the Use of Laboratory Animals in Biomedical and ... -- ARTHUR C. GUYTON -- CHRISTINE STEVENS -- Appendix A 1896 Report of the National Academy of Sciences -- Appendix B Curricula Vitae of Committee Members -- Appendix C Invited Speakers at Committee Meetings -- Index. 330 $aScientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action. 606 $aAnimal experimentation 606 $aVivisection 606 $aLaboratory animals 615 0$aAnimal experimentation. 615 0$aVivisection. 615 0$aLaboratory animals. 676 $a619 712 02$aNational Research Council (U.S.).$bCommittee on the Use of Laboratory Animals in Biomedical and Behavioral Research. 712 02$aInstitute of Medicine (U.S.) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910953849203321 996 $aUse of laboratory animals in biomedical and behavioral research$94360740 997 $aUNINA