LEADER 03179nam 2200637Ia 450 001 9910969143103321 005 20200520144314.0 010 $a9786612117602 010 $a9781282117600 010 $a1282117602 010 $a9781444311365 010 $a1444311360 035 $a(CKB)1000000000719742 035 $a(EBL)428018 035 $a(OCoLC)437111583 035 $a(SSID)ssj0000360473 035 $a(PQKBManifestationID)11286925 035 $a(PQKBTitleCode)TC0000360473 035 $a(PQKBWorkID)10325083 035 $a(PQKB)11510190 035 $a(MiAaPQ)EBC428018 035 $a(Au-PeEL)EBL428018 035 $a(CaPaEBR)ebr10303747 035 $a(CaONFJC)MIL211760 035 $a(Perlego)2760837 035 $a(EXLCZ)991000000000719742 100 $a20000510d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGene transcription $emechanisms and control /$fRobert J. White 205 $a1st ed. 210 $aLondon ;$aMalden, MA $cBlackwell Science$d2001 215 $a1 online resource (290 p.) 300 $aDescription based upon print version of record. 311 08$a9780632048885 311 08$a0632048883 320 $aIncludes bibliographical references and index. 327 $aGene Transcription Mechanisms and Control; Contents; Preface; Abbreviations; Chapter 1: Introduction; Chapter 2: The Nuclear RNA Polymerases; Chapter 3: DNA Recognition by Transcription Factors; Chapter 4: Basal Transcription by RNA Polymerase II; Chapter 5: Activating RNA Polymerase II Transcription; Chapter 6: Transcription by RNA Polymerase I; Chapter 7: Transcription by RNA Polymerase III; Chapter 8: The Influence of Chromatin on Transcription; Chapter 9: Controlling Transcription Factor Production; Chapter 10: Regulation of Transcription Factor Localization 327 $aChapter 11: Regulation of Transcription Factor ActivityChapter 12: Cell Cycle Regulation of Transcription; Chapter 13: Interactions Between Transcription and Other Nuclear Processes; Chapter 14: Transcription Factors and Development; Index 330 $aTranscription is the focus of much cutting-edge research, as befits its essential place in biology. The established link between defects in gene transcription and many human disorders has fuelled considerable activity in the biomedical arena, particularly cancer research. This concentration of attention has uncovered a myriad of factors involved in transcription and the literature is now rife with jargon and complexity. Gene Transcription: Mechanisms and Control aims to demystify the subject for a non-expert audience, providing a guided tour around the complex machinery of the transc 606 $aGenetic transcription 606 $aGenetic transcription$xRegulation 615 0$aGenetic transcription. 615 0$aGenetic transcription$xRegulation. 676 $a572.8/845 700 $aWhite$b Robert J.$f1963-$01809864 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910969143103321 996 $aGene transcription$94360875 997 $aUNINA LEADER 04835nam 2200769Ia 450 001 9910953146603321 005 20200520144314.0 010 $a9786611237417 010 $a9781281237415 010 $a1281237418 010 $a9780470249031 010 $a047024903X 010 $a9780470249024 010 $a0470249021 035 $a(CKB)1000000000401090 035 $a(EBL)333797 035 $a(OCoLC)476138555 035 $a(SSID)ssj0000226315 035 $a(PQKBManifestationID)11235959 035 $a(PQKBTitleCode)TC0000226315 035 $a(PQKBWorkID)10257897 035 $a(PQKB)10882296 035 $a(MiAaPQ)EBC333797 035 $a(Au-PeEL)EBL333797 035 $a(CaPaEBR)ebr10226748 035 $a(CaONFJC)MIL123741 035 $a(OCoLC)176895587 035 $a(FINmELB)ELB177538 035 $a(Perlego)2773560 035 $a(EXLCZ)991000000000401090 100 $a20080125d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aPreclinical development handbook$iADME and biopharmaceutical properties /$f[edited by] Shayne Cox Gad 205 $a1st ed. 210 $aHoboken, N.J. $cWiley-Interscience$dc2008 215 $a1 online resource (1347 p.) 225 1 $aPharmaceutical Development Series ;$vv.3 300 $aDescription based upon print version of record. 311 08$a9780470248478 311 08$a0470248475 320 $aIncludes bibliographical references and index. 327 $aPRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration 327 $a10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions 327 $a23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies 327 $a33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; Index 330 $aA clear, straightforward resource to guide you through preclinical drug developmentFollowing this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.Each chapter is written by one or more leadin 410 0$aPharmaceutical Development Series 517 3 $aADME and biopharmaceutical properties 606 $aPharmacokinetics$vHandbooks, manuals, etc 606 $aDrug development$vHandbooks, manuals, etc 615 0$aPharmacokinetics 615 0$aDrug development 676 $a615.1901 676 $a615.7 676 $a615/.7 701 $aGad$b Shayne C.$f1948-$096171 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910953146603321 996 $aPreclinical development handbook$94367994 997 $aUNINA