LEADER 05560nam 22006255 450 001 9910951903403321 005 20250127115243.0 010 $a9789819602599 010 $a9819602599 024 7 $a10.1007/978-981-96-0259-9 035 $a(CKB)37391363100041 035 $a(MiAaPQ)EBC31892457 035 $a(Au-PeEL)EBL31892457 035 $a(DE-He213)978-981-96-0259-9 035 $a(OCoLC)1499720591 035 $a(EXLCZ)9937391363100041 100 $a20250127d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMulti-Factorial Approach as a Therapeutic Strategy for the Management of Alzheimer?s Disease /$fedited by Ghulam Md Ashraf, Ali T. Zari, Md. Habibur Rahman, Chenmala Karthika, Veera Venkata Satyanarayana Reddy Karri 205 $a1st ed. 2024. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024. 215 $a1 online resource (595 pages) 311 08$a9789819602582 311 08$a9819602580 327 $aPart 1. Basic Concepts of neurodegeneration and Alzheimer?s disorder -- Basic anatomy and physiology of the central nervous system -- Neurodegenerative disorders: Types, Classification, and basic concepts -- Alzheimer?s disorder: epidemiology, etiology, risk factors, future predictions -- Pathophysiology and underlying mechanisms: pathways to Alzheimer?s plaque formation -- Correlation of Alzheimer?s and other psychologic and non-psychologic conditions -- Part 2. Current scenario of Alzheimer?s disorder -- Hurdles & strategies in treating Alzheimer?s disorder -- Diagnosis of Alzheimer?s, types of plaques and their detection, imaging techniques, and other tests -- Current drugs used: classification, pharmacology -- Approved drug regimens, combinations, and delivery systems for Alzheimer?s disorder -- Traditional therapies for Alzheimer?s disorder -- Part 3. Novel therapeutic approaches to Alzheimer?s Therapy -- Nanotechnology in Alzheimer?s -- Targeted drug delivery: amyloid beta targeting drugs, immunotherapy, anti-tau, and aggregation inhibitor, microtubule-stabilizing, and neuro-inflammation modulation -- Neuroprotective approach, microbiome therapy, and overcoming insulin resistance in the brain -- Nonpharmacological approaches: Brain stimulations, vagus nerve stimulation, magnetic and electrical transcranial stimulations -- Part 4. Alzheimer?s drug development -- Understanding the potential targets of Alzheimer?s disorder -- Upcoming nano and conventional drug delivery strategies for Alzheimer?s disorder -- Animal models and ethics in the testing of drugs for Alzheimer?s disorder -- Regulatory guidelines and approval process for drugs and formulations for AD -- Part 5. Future of Alzheimer?s disorder -- Prevention and reduction of risk of AD: lifestyle changes, dietary changes, supplements, etc -- Natural medicines (phytoconstituents) and probiotics as the future of Alzheimer?s Disorder -- Future barriers and possible solutions with recent advances in the field of Alzheimer?s disease. 330 $aThis book is a comprehensive guide to the pathology, underlying mechanisms, and treatment options for Alzheimer's disease (AD). The book starts with an introduction to the basic anatomy and physiology of the central nervous system, followed by an overview of the types, classifications, and basic concepts of neurodegenerative disorders. The epidemiology, etiology, risk factors, and future predictions of AD have been covered in detail. The book then delves into the pathophysiology and underlying mechanisms of plaque formation and explores the correlation of AD with other psychological and non-psychological conditions. The chapters also explore the diagnosis of AD, including types of plaques and their detection, imaging techniques, and other tests. The book also covers traditional therapies for AD and explores the potential application of nanotechnology in AD treatment. The book also covers animal models and ethics in the testing of drugs for AD, regulatory guidelines, and the approval process for drugs and formulations for AD. Prevention and reduction of AD risk are explored, including lifestyle changes, dietary changes, supplements, natural medicines (phytoconstituents), and probiotics as the future of AD. The book concludes with a discussion of future barriers and possible solutions with recent advances in the field of AD. This book is an essential guide for students, researchers, and healthcare professionals interested in Alzheimer's disease research. 606 $aNeurosciences 606 $aNeuropharmacology 606 $aNervous system$xDiseases 606 $aNeuroscience 606 $aNeuropharmacology 606 $aNeurological Disorders 615 0$aNeurosciences. 615 0$aNeuropharmacology. 615 0$aNervous system$xDiseases. 615 14$aNeuroscience. 615 24$aNeuropharmacology. 615 24$aNeurological Disorders. 676 $a612.8 700 $aAshraf$b Ghulam$01809411 701 $aZari$b Ali T$01809412 701 $aRahman$b Habibur$01809413 701 $aKarthika$b Chenmala$01809414 701 $aKarri$b Veera Venkata Satyanarayana Reddy$01809415 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910951903403321 996 $aMulti-Factorial Approach as a Therapeutic Strategy for the Management of Alzheimer?s Disease$94360189 997 $aUNINA