LEADER 04347nam 22006735 450 001 9910899891703321 005 20241027115928.0 010 $a3-031-63118-8 024 7 $a10.1007/978-3-031-63118-4 035 $a(MiAaPQ)EBC31741927 035 $a(Au-PeEL)EBL31741927 035 $a(CKB)36410318300041 035 $a(DE-He213)978-3-031-63118-4 035 $a(EXLCZ)9936410318300041 100 $a20241027d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHuman Challenge Studies for Vaccine Development /$fedited by Fabio Bagnoli, Giuseppe Del Giudice, Sanjay K. Phogat, Rino Rappuoli 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (380 pages) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v445 311 $a3-031-63117-X 327 $aA brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d?etre, ethnography, selection of volunteers and unit design -- Regulatory aspects of human challenge studies.-Controlled Human Infection challenge studies with RSV -- Human challenge studies with coronaviruses old and new -- Experimental urethral infection with Neisseria gonorrhoeae -- Helicobacter pylori.-Controlled human infection with Bordetella pertussis Human challenge studies for cholera -- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli -- Challenges in developing a controlled human tuberculosis challenge model -- Shigella Controlled Human Infection Models: Current and Future Perspectives -- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella -- Controlled Human Malaria Infection studies in Africa - past, present, and future -- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development. 330 $aThis volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v445 606 $aImmunology 606 $aMedical microbiology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aDiseases$xCauses and theories of causation 606 $aImmunology 606 $aMedical Microbiology 606 $aTranslational Research 606 $aPathogenesis 615 0$aImmunology. 615 0$aMedical microbiology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aDiseases$xCauses and theories of causation. 615 14$aImmunology. 615 24$aMedical Microbiology. 615 24$aTranslational Research. 615 24$aPathogenesis. 676 $a615.372 700 $aBagnoli$b Fabio$01767604 701 $aDel Giudice$b Giuseppe$06182 701 $aPhogat$b Sanjay K$01767605 701 $aRappuoli$b Rino$01721430 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910899891703321 996 $aHuman Challenge Studies for Vaccine Development$94213923 997 $aUNINA