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024 7 $a10.1007/978-3-658-46377-9
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035   $a(DE-He213)978-3-658-46377-9
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101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aExamination of the in vitro Regenerative and Neuroprotective Potential of Short Chain Fatty Acid Butyrate /$fby Clarissa Annabella Lohmann
205   $a1st ed. 2024.
210  1$aWiesbaden :$cSpringer Fachmedien Wiesbaden :$cImprint: Springer,$d2024.
215   $a1 online resource (88 pages)
225 1 $aBestMasters,$x2625-3615
311 08$a9783658463762 
311 08$a3658463767 
327   $aIntroduction -- Aims -- Materials -- Methods -- Results -- Discussion -- Conclusion and Outlook.
330   $aImmune-mediated polyneuropathies stem from dysregulation of the immune system and affect a wide range of the population. Inflammatory diseases such as chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barré syndrome (GBS) are the most common acute and chronic treatable immune-mediated polyneuropathies. The immune system mediates primarily demyelination but also neuronal degeneration through oxidative stress. As a result, patients suffer from hyporeflexia or areflexia accompanied with sensory and motor deficits as the disease progresses, which can lead to hospitalization and death. Over the years, nutrition and intestinal metabolism have become more relevant for the regulation of the immune system. In particular, short chain fatty acids (SCFA) have become the focus of attention. Currently, the best-studied SCFA is butyrate, produced by bacteria in the intestine along with propionate and acetate. Butyrate has already achieved promising results in areas such as oncology and immunology. Now, in the context of this master thesis, the question arises of the neuroprotective and neuroregenerative abilities of butyrate under oxidative stress. Die Autorin Clarissa Annabella Lohmann is PhD Student in Multiple Sclerosis Research in the Department of Neuropathology at the Georg August University Göttingen and the Fraunhofer ITMP - Translational Neuroinflammation and Automated Microscopy TNM.
410  0$aBestMasters,$x2625-3615
606   $aNeurology
606   $aNeuroimmunology
606   $aOncology
606   $aNervous system$xDiseases
606   $aDiseases
606   $aNeurology
606   $aNeuroimmunology
606   $aOncology
606   $aNeurological Disorders
606   $aDiseases
615  0$aNeurology.
615  0$aNeuroimmunology.
615  0$aOncology.
615  0$aNervous system$xDiseases.
615  0$aDiseases.
615 14$aNeurology.
615 24$aNeuroimmunology.
615 24$aOncology.
615 24$aNeurological Disorders.
615 24$aDiseases.
676   $a616.8
700   $aLohmann$b Clarissa Annabella$01766802
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910897981303321
996   $aExamination of the in Vitro Regenerative and Neuroprotective Potential of Short Chain Fatty Acid Butyrate$94211519
997   $aUNINA