LEADER 04629nam 22007095 450 001 9910896194103321 005 20250808085432.0 010 $a3-031-68730-2 024 7 $a10.1007/978-3-031-68730-3 035 $a(MiAaPQ)EBC31708169 035 $a(Au-PeEL)EBL31708169 035 $a(CKB)36292758600041 035 $a(DE-He213)978-3-031-68730-3 035 $a(EXLCZ)9936292758600041 100 $a20241005d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGene Regulation and Epigenetics $eHow Science Works /$fby Carsten Carlberg 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (268 pages) 311 08$a3-031-68729-9 327 $a1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: nuclear receptors -- 6. Genome-wide principles of gene regulation -- 7. DNA methylation -- 8. Histone modifications -- 9. Chromatin remodeling and organization -- 9. Regulatory impact of ncRNA -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and immunity -- 14. Epigenetics and disease -- 15. Cancer epigenetics -- 16. Nutritional epigenetics. 330 $aThis book delves into the fascinating realm of eukaryotic gene regulation. The specific expression of genes shapes the phenotype of cells and tissues. The regulation of gene expression, including up- and downregulation, is a fundamental aspect of nearly all physiological processes, both in health and disease. These dynamic processes respond to various daily challenges, such as dietary changes and infections. Therefore, it is crucial for not only biologists and biochemists but also all students in biomedical disciplines to understand gene regulation concepts. This foundational knowledge will benefit them in their specialized fields. A comprehensive understanding of transcription factors and the mechanisms that alter their activity is a fundamental goal of modern life science research. Epigenetics refers to the packaging and accessibility of the genome in each of the trillions of cells in our bodies. The prefix ?epi? (meaning ?upon,? ?above,? or ?beyond?) indicates that epigenetic processes do not alter the DNA sequence of our genome, adding a layer of information beyond that encoded in our genome. Genomic DNA is wrapped around complexes of histone proteins, helping it fit into a cell nucleus with a diameter of less than 10 ?m. This protein-DNA complex is known as chromatin. The content of this book is linked to the ?Molecular Medicine and Genetics? course, which the author has lectured on in various forms since 2002 at the University of Eastern Finland in Kuopio. This book is an updated version of the textbooks ?Mechanisms of Gene Regulation? and ?Human Epigenomics.? It is divided into 16 chapters. Following two introductory chapters, four chapters explore gene regulation from the perspective of transcription factors, while another four chapters focus on chromatin and non-coding RNA. Three chapters then discuss the impact of epigenetics from a health perspective, and the final three chapters address epigenetics from the perspective of diseases. A glossary in the appendix explains the major specialist terms. 606 $aMolecular biology 606 $aGenetic transcription 606 $aEpigenetics 606 $aGenomics 606 $aMolecular genetics 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMolecular Biology 606 $aGene Transcription 606 $aEpigenetics 606 $aGenomics 606 $aMolecular Genetics 606 $aBiomedical Research 615 0$aMolecular biology. 615 0$aGenetic transcription. 615 0$aEpigenetics. 615 0$aGenomics. 615 0$aMolecular genetics. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aMolecular Biology. 615 24$aGene Transcription. 615 24$aEpigenetics. 615 24$aGenomics. 615 24$aMolecular Genetics. 615 24$aBiomedical Research. 676 $a572 700 $aCarlberg$b Carsten$0849346 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910896194103321 996 $aGene Regulation and Epigenetics$94214580 997 $aUNINA