LEADER 06141nam 2201741z- 450 001 9910557533903321 005 20210501 035 $a(CKB)5400000000044238 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69421 035 $a(oapen)doab69421 035 $a(EXLCZ)995400000000044238 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNew Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (318 p.) 311 08$a3-03943-777-1 311 08$a3-03943-778-X 330 $aTrauma represents a leading cause of death, particularly in the younger population. Traumatic brain injury and hemorrhage are the most common causes of early death, whereas complications such as infections, (multi-)organ failure and "persistent inflammation, immunosuppression, and catabolism syndrome" (PICS) represent relevant factors for late adverse outcomes. Pre- and intra-hospital diagnostic and therapeutic standard operating procedures have been shown to beneficially influence posttraumatic outcome. However, development of patient-specific diagnostic and therapeutic strategies remains challenging due to uncertainties regarding the assessment of the individual risk profile. Furthermore, the relevance of prevention and rehabilitation measures to avoid unfavorable long-term consequences of trauma is not fully elucidated. With this Special Issue, we wanted to reflect the current knowledge about the pathomechanisms associated with the impact of severe injury and its consequences for the further clinical course on the one hand, and to point out new insights in regard to diagnostic and therapeutic approaches on the other hand. 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