LEADER 01096nas 2200385 c 450 001 9910894939303321 005 20250513221312.0 024 8 $aKir3327 024 8 $aVD18 90123123 035 $a(CKB)3790000000122674 035 $a(DE-599)ZDB2640930-6 035 $a(OCoLC)835575598 035 $a(DE-101)1017767742 035 $a(EXLCZ)993790000000122674 100 $a20111206b17881796 |y | 101 0 $ager 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMagazin für allgemeine Natur- und Thiergeschichte$fhrsg. von C.F.A. Müller 210 31$aGo?ttingen$aLeipzig$cBrose$d1788-1796 215 $aOnline-Ressource 517 1 $aTiergeschichte 608 $aZeitschrift$2gnd-content 676 $a500 686 $a11$2ssgn 702 $aMu?ller$b Carl Friedrich August$f1777-1837$4ctb 801 0$b0361 801 1$bDE-101 801 2$b9999 906 $aJOURNAL 912 $a9910894939303321 996 $aMagazin fu?r allgemeine Natur- und Thiergeschichte$94262754 997 $aUNINA LEADER 01887nam0 22004333i 450 001 VAN00261725 005 20240806101506.44 017 70$2N$a9783540392422 100 $a20230720d1980 |0itac50 ba 101 $aeng 102 $aDE 105 $a|||| ||||| 200 1 $aˆThe ‰Determination of Units in Real Cyclic Sextic Fields$fSirpa Mäki 210 $aBerlin$cSpringer$d1980 215 $aiii, 201 p.$cill.$d24 cm 461 1$1001VAN00102250$12001 $aLecture notes in mathematics$1210 $aBerlin [etc.]$cSpringer$v797 606 $a11-XX$xNumber theory [MSC 2020]$3VANC019688$2MF 606 $a11R18$xCyclotomic extensions [MSC 2020]$3VANC021827$2MF 606 $a11R21$xOther number fields [MSC 2020]$3VANC021807$2MF 606 $a11R27$xUnits and factorization [MSC 2020]$3VANC021759$2MF 606 $a11R29$xClass numbers, class groups, discriminants [MSC 2020]$3VANC019989$2MF 606 $a11Y40$xAlgebraic number theory computations [MSC 2020]$3VANC019992$2MF 610 $aClass count$9KW:K 610 $aCyclic Sextic Fields$9KW:K 610 $aFields$9KW:K 610 $aFunctions$9KW:K 610 $aNumber fields$9KW:K 610 $aUnits$9KW:K 620 $dBerlin$3VANL000066 700 1$aMäki$bSirpa$3VANV216103$055821 712 $aSpringer $3VANV108073$4650 801 $aIT$bSOL$c20250606$gRICA 856 4 $uhttps://doi.org/10.1007/BFb0088938$zE-book ? Accesso al full-text attraverso riconoscimento IP di Ateneo, proxy e/o Shibboleth 899 $aBIBLIOTECA DEL DIPARTIMENTO DI MATEMATICA E FISICA$1IT-CE0120$2VAN08 912 $fN 912 $aVAN00261725 950 $aBIBLIOTECA DEL DIPARTIMENTO DI MATEMATICA E FISICA$d08DLOAD e-book 6327 $e08eMF6327 20230731 996 $aDetermination of units in real cyclic sextic fields$981082 997 $aUNICAMPANIA LEADER 03992nam 22006015 450 001 9910155326503321 005 20200702123627.0 010 $a9783319451299 024 7 $a10.1007/978-3-319-45129-9 035 $a(CKB)3710000000964788 035 $a(DE-He213)978-3-319-45129-9 035 $a(MiAaPQ)EBC4751449 035 $a(PPN)197138543 035 $a(EXLCZ)993710000000964788 100 $a20161130d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition /$fby Yogambigai Velmurugu 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XXI, 199 p. 112 illus., 105 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-319-45128-6 311 $a3-319-45129-4 320 $aIncludes bibliographical references. 327 $aIntroduction -- Methods -- Integration Host Factor (IHF)-DNA interaction -- Lesion Recognition by Xeroderma Pigmentosum C (XPC) Protein -- DNA Mismatch Repair. 330 $aUsing a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually ?stumbles? upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins. . 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aBiophysics 606 $aBiophysics 606 $aSpectrum analysis 606 $aMicroscopy 606 $aProteins 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aSpectroscopy and Microscopy$3https://scigraph.springernature.com/ontologies/product-market-codes/P31090 606 $aProtein-Ligand Interactions$3https://scigraph.springernature.com/ontologies/product-market-codes/L14060 615 0$aBiophysics. 615 0$aBiophysics. 615 0$aSpectrum analysis. 615 0$aMicroscopy. 615 0$aProteins. 615 14$aBiological and Medical Physics, Biophysics. 615 24$aSpectroscopy and Microscopy. 615 24$aProtein-Ligand Interactions. 676 $a571.4 700 $aVelmurugu$b Yogambigai$4aut$4http://id.loc.gov/vocabulary/relators/aut$0819544 906 $aBOOK 912 $a9910155326503321 996 $aDynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition$91826398 997 $aUNINA