LEADER 01674nam0-2200541---450- 001 990000089850203316 005 20140617110144.0 010 $a84-7143-769-4 035 $a0008985 035 $aUSA010008985 035 $a(ALEPH)000008985USA01 035 $a0008985 100 $a20000914d1990----|||y0itay0103----ba 101 0 $aspa 102 $aES 105 $a||||||||001yy 200 1 $aCurso intensivo de espanol$fJ.Fernàndez, R.Fente, J.Siles 210 $aAlcobendas$cSociedad General Español$d1990 215 $a239 p.$d26 cm 606 0 $aLingua spagnola$xGrammatica 676 $a468 700 1$aFERNANDEZ,$bJulio$0409507 701 1$aFENTE,$bR.$0747066 701 1$aSILES,$bJ.$0747067 801 $aIT$bSALBC$gISBD 912 $a990000089850203316 951 $aVI.5.D. 102(II sp B 1/69 I)$b153804 L.M.$cII sp B 1/69$d00005618 959 $aBK 969 $auma 979 $c20000914$lUSA01$h1741 979 $c20001019$lUSA01$h1056 979 $c20001019$lUSA01$h1454 979 $c20001019$lUSA01$h1501 979 $c20001019$lUSA01$h1539 979 $c20001024$lUSA01$h1515 979 $c20001027$lUSA01$h1519 979 $c20001027$lUSA01$h1524 979 $c20001110$lUSA01$h1710 979 $c20001124$lUSA01$h1208 979 $c20020403$lUSA01$h1616 979 $aALESSANDRA$b90$c20030729$lUSA01$h1131 979 $aPATRY$b90$c20040406$lUSA01$h1607 979 $aCOPAT6$b90$c20050614$lUSA01$h1607 979 $aPATRY$b90$c20051201$lUSA01$h1531 979 $aCOPAT6$b90$c20070622$lUSA01$h1355 979 $aPATRY$b90$c20140617$lUSA01$h1101 996 $aCurso intensivo de espanol$91491945 997 $aUNISA LEADER 01733oam 2200541M 450 001 9910716145103321 005 20200213070926.1 035 $a(CKB)5470000002518665 035 $a(OCoLC)1065610603 035 $a(OCoLC)995470000002518665 035 $a(EXLCZ)995470000002518665 100 $a20071213d1926 ua 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aJuan Anorbe. June 4, 1926. -- Ordered to be printed 210 1$a[Washington, D.C.] :$c[U.S. Government Printing Office],$d1926. 215 $a1 online resource (2 pages) 225 1 $aSenate report / 69th Congress, 1st session. Senate ;$vno. 998 225 1 $a[United States congressional serial set] ;$v[serial no. 8528] 300 $aBatch processed record: Metadata reviewed, not verified. Some fields updated by batch processes. 300 $aFDLP item number not assigned. 606 $aCanals 606 $aClaims 606 $aIndustrial accidents 606 $aIndustrial safety 606 $aWorkers' compensation 606 $aCivil service 606 $aConstruction 608 $aLegislative materials.$2lcgft 615 0$aCanals. 615 0$aClaims. 615 0$aIndustrial accidents. 615 0$aIndustrial safety. 615 0$aWorkers' compensation. 615 0$aCivil service. 615 0$aConstruction. 701 $aMeans$b Rice William$f1877-1949$pRepublican (CO)$01386800 801 0$bWYU 801 1$bWYU 801 2$bOCLCO 801 2$bOCLCQ 906 $aBOOK 912 $a9910716145103321 996 $aJuan Anorbe. June 4, 1926. -- Ordered to be printed$93448201 997 $aUNINA LEADER 04666nam 22006015 450 001 9910437845803321 005 20200704030608.0 010 $a3-642-25240-0 024 7 $a10.1007/978-3-642-25240-2 035 $a(CKB)3460000000120436 035 $a(DE-He213)978-3-642-25240-2 035 $a(SSID)ssj0000878763 035 $a(PQKBManifestationID)11479432 035 $a(PQKBTitleCode)TC0000878763 035 $a(PQKBWorkID)10837012 035 $a(PQKB)10395523 035 $a(MiAaPQ)EBC3095795 035 $a(Au-PeEL)EBL3095795 035 $a(CaPaEBR)ebr10969113 035 $a(OCoLC)830312292 035 $a(PPN)169137767 035 $a(EXLCZ)993460000000120436 100 $a20130305d2013 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDrug Discovery and Evaluation: Safety and Pharmacokinetic Assays /$fedited by H. Gerhard Vogel, Jochen Maas, Franz J. Hock, Dieter Mayer 205 $a2nd ed. 2013. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013. 215 $a1 online resource (XXIV, 1404 p. 243 illus. eReference.) 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a3-642-25241-9 311 08$a3-642-25239-7 327 $aFrom the contents: General Introduction: Safety Pharmacology -- Safety Pharmacokinetics -- Safety Toxicology. 330 $aSafety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function. Toxicological and pharmacokinetic studies were adapted to the progress of studies in clinical pharmacology and clinical trails. But the success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. A change of strategy was therefore adopted, involving the following changes: -          Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). -          The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group. Easily accessible and the most informative tests now have to be selected. -          Exposure of a drug to the body by pharmacokinetic studies on absorption, distribution, metabolism and excretion has to be investigated at an early stage of development and can contribute to the selection of a compound for development. Toxicology experienced major achievements by the introduction of new methods, e.g., in silico methods, toxicogenomics and toxicoproteomics. The book is a landmark in the continuously changing world of drugs. As such it is important reading for many groups: not only for all students of pharmacology and toxicology but also for physicians, especially those involved in clinical trials of drugs, and for pharmacists who have to know the safety requirements of drugs. The book is absolutely essential for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process. In particular, the book will be of use for government institutions and committees working on official guidelines for drug evaluation worldwide. 606 $aPharmacology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 615 0$aPharmacology. 615 14$aPharmacology/Toxicology. 676 $a615 702 $aVogel$b H. Gerhard$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMaas$b Jochen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHock$b Franz J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMayer$b Dieter$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437845803321 996 $aDrug discovery and evaluation$9512478 997 $aUNINA LEADER 03577nam 22005053 450 001 9910888075903321 005 20221219084638.0 010 $a9783428573783 010 $a3428573781 035 $a(CKB)5690000000011458 035 $a(MiAaPQ)EBC7101313 035 $a(Au-PeEL)EBL7101313 035 $a(OCoLC)1347025733 035 $a(Exl-AI)7101313 035 $a(EXLCZ)995690000000011458 100 $a20221219d2022 uy 0 101 0 $ager 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aDie Deutschen Arbeitgeber-Verbände. $eIm Auftrage des Vereins für Socialpolitik herausgegeben. (Schriften des Vereins für Socialpolitik 124) 205 $a1st ed. 210 1$aBerlin :$cDuncker & Humblot,$d2022. 210 4$d©1907. 215 $a1 online resource (403 pages) 225 1 $aDuncker & Humblot reprints 311 08$a9783428173785 311 08$a3428173783 327 $aVorwort -- Vorbemerkungen des Verfassers -- Literatur -- Inhaltsverzeichnis -- Inhaltsverzeichnis des Anhangs -- Erster Teil. Geschichte und Organisation der Arbeitgeberverbände -- 1. Kapitel. Unternehmervereine und Arbeitgeberverbände -- 2. Kapitel. Geschichte der Arbeitgeberverbände bis zum Crimmitschauer Streik -- 3. Kapitel. Geschichte der Arbeitgeberverbände seit dem Crimmitschauer Streik -- 4. Kapitel. Der gegenwärtige Stand der Arbeitgeberorganisation -- 5. Kapitel. Die innere Organisation der Arbeitgeberverbände -- Zweiter Teil. Tätigkeit der Arbeitgeberverbände -- Vorbemerkungen -- 6. Kapitel. Maßnahmen zur Verhütung von Arbeiterbewegungen und Streiks -- a) Persönliche ?Maßregelungen" -- b) Sachliche Maßregeln -- 7. Kapitel. Maßnahmen zur Bekämpfung und Unschädlichmachung der Streiks -- Anerkennung der Gewerkschaften -- Prüfung des Streiks -- Der Arbeitgeberverband als Vormund seiner Mitglieder -- Verbot der Beschäftigung Streikender -- Beschaffung von Streikbrechern -- Streikarbeit -- Streikklausel -- Kundenschutzvertrag -- Aussperrungen -- Materialiensperre -- Die Arbeitswilligen -- Streikunterstützung und Streikversicherung -- 8. Kapitel. Paritätische Vereinbarungen mit der Arbeiterschaft$7Generated by AI. 330 $aThis book, authored by Dr. Gerhard Kessler and published in 1907, provides a comprehensive analysis of the development and organization of employer associations in Germany. Commissioned by the Verein für Socialpolitik, it addresses the complexities and rapid evolution of these associations during the early 20th century. The author meticulously gathered data over two years, synthesizing information from various sources to offer an insightful exploration of the subject. The book aims to shed light on the social and economic implications of employer associations, making it a valuable resource for scholars, policymakers, and individuals interested in labor relations and industrial organization.$7Generated by AI. 410 0$aDuncker & Humblot reprints 517 $aDeutschen Arbeitgeber-Verbände 606 $aEmployers' associations$7Generated by AI 606 $aIndustrial relations$zGermany$7Generated by AI 615 0$aEmployers' associations 615 0$aIndustrial relations 700 $aKessler$b Gerhard$01769301 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910888075903321 996 $aDie Deutschen Arbeitgeber-Verbände$94239102 997 $aUNINA