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010   $a981-9728-59-2
024 7 $a10.1007/978-981-97-2859-6
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035   $a(MiAaPQ)EBC31651889
035   $a(Au-PeEL)EBL31651889
035   $a(DE-He213)978-981-97-2859-6
035   $a(EXLCZ)9934868856100041
100   $a20240906d2024      u|         0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aApplication of Nanocarriers in Brain Delivery of Therapeutics /$fedited by Amit Alexander
205   $a1st ed. 2024.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2024.
215   $a1 online resource (398 pages)
311 08$a981-9728-58-4 
320   $aIncludes bibliographical references.
327   $aChapter 1. Introduction to complex brain disorders, currently available therapies, and their limitations -- Chapter 2. Challenges of brain targeting and mechanism of drug transfer across BBB -- Chapter 3. Introduction to nanoparticles as a potential carrier for brain targeting -- Chapter 4. Application of polymeric nanoparticles in brain targeting -- Chapter 5. Recent advancements in lipid nanocarriers for brain delivery of bioactive -- Chapter 6. Liposomes as a potential carrier for brain delivery -- Chapter 7. Inorganic nanoparticles for brain targeting: scope and limitations -- Chapter 8. Potential of dendrimers as a nanocarrier for brain delivery -- Chapter 9. Surface active ligands for enhanced brain targeting of nanoparticles -- Chapter 10. Stimuli-responsive polymers for brain delivery -- Chapter 11. In vitro cell line development and their limitations for brain research -- Chapter 12. In vivo Animal model development and their limitation for brain research -- Chapter 13. Safety, stability concerns, and regulatory aspects of Nanocarriers for brain delivery -- Chapter 14. Current clinical advancements of nanocarriers for brain targeting and limitations in clinical translation.
330   $aThis book presents nanoparticles as potential drug delivery carriers for overcoming the blood-brain barrier. The initial chapter of the book discusses complex brain disorders, the currently available therapies, and their limitations. The book discusses the potential applications of polymeric nanoparticles, lipid nanocarriers, liposomes, inorganic nanoparticles, dendrimers, and stimuli-responsive polymers for targeted brain drug delivery. Further, it evaluates the development and role of different cell lines and animal models in brain research. Towards the end, the book reviews challenges, safety, toxicity, regulatory aspects, future possibilities, and constraints in the clinical translation of nanocarrier systems to treat neurological disorders. The book as such provides valuable information to neuroscientists, and researchers working in pharmaceuticals, nanomedicine, drug delivery research, and nanotechnology.
606   $aPharmacology
606   $aNeuropharmacology
606   $aNanobiotechnology
606   $aPharmacology
606   $aNeuropharmacology
606   $aNanobiotechnology
615  0$aPharmacology.
615  0$aNeuropharmacology.
615  0$aNanobiotechnology.
615 14$aPharmacology.
615 24$aNeuropharmacology.
615 24$aNanobiotechnology.
676   $a616.8
700   $aAlexander$b Amit$01769123
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910886996603321
996   $aApplication of Nanocarriers in Brain Delivery of Therapeutics$94430544
997   $aUNINA