LEADER 03383nam 22005415 450 001 9910886988303321 005 20240904130710.0 010 $a3-031-66776-X 024 7 $a10.1007/978-3-031-66776-3 035 $a(MiAaPQ)EBC31648299 035 $a(Au-PeEL)EBL31648299 035 $a(CKB)34825782500041 035 $a(DE-He213)978-3-031-66776-3 035 $a(EXLCZ)9934825782500041 100 $a20240904d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAdrenoceptors /$fedited by Jillian G. Baker, Martin C. Michel, Roger J. Summers 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (691 pages) 225 1 $aHandbook of Experimental Pharmacology,$x1865-0325 ;$v285 311 $a3-031-66775-1 327 $aIntroduction: a short history of adrenoceptor research -- Structures of Adrenoceptors -- Genetic Variants of Adrenoceptors -- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays -- Signalling of adrenoceptors: canonical pathways and new paradigms -- Presynaptic Adrenoceptors -- Roles of b-adrenoceptor subtypes and therapeutics in human cardiovascular disease:- heart failure, tachyarrhythmias and other cardiovascular disorders -- Adrenoceptors and Hypertension -- Adrenoceptors in the Lower Urinary Tract -- Asthma and COPD: A Focus on b-Agonists ? Past, Present and Future -- Adrenoceptors in the Eye- Physiological and Pathophysiological Relevance -- Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments -- Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease -- Clinical use of adrenergic receptor ligands in acute care settings -- Adrenoceptor expression and function in the endocrine pancreas -- b-adrenoceptors in cancer: old players and new perspectives. 330 $aAdrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field. 410 0$aHandbook of Experimental Pharmacology,$x1865-0325 ;$v285 606 $aPharmacology 606 $aDrugs$xDesign 606 $aPharmacology 606 $aStructure-Based Drug Design 615 0$aPharmacology. 615 0$aDrugs$xDesign. 615 14$aPharmacology. 615 24$aStructure-Based Drug Design. 676 $a615 700 $aBaker$b Jillian G$01768466 701 $aMichel$b Martin C$01768467 701 $aSummers$b Roger J$01768468 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910886988303321 996 $aAdrenoceptors$94229449 997 $aUNINA