LEADER 05495nam 22005775 450 001 9910886079203321 005 20250807135922.0 010 $a3-031-55529-5 024 7 $a10.1007/978-3-031-55529-9 035 $a(MiAaPQ)EBC31626726 035 $a(Au-PeEL)EBL31626726 035 $a(CKB)34512767700041 035 $a(DE-He213)978-3-031-55529-9 035 $a(EXLCZ)9934512767700041 100 $a20240830d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMicroglia $ePhysiology, Pathophysiology and Therapeutic Potential /$fedited by Marie-Ève Tremblay, Alexei Verkhratsky 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (635 pages) 225 1 $aAdvances in Neurobiology,$x2190-5223 ;$v37 311 08$a3-031-55528-7 327 $aPART I: Introduction -- Chapter 1: General Pathophysiology of Microglia -- Chapter 2: History of Microglia -- Chapter 3: Evolution of Microglia -- Chapter 4: Visualization, Fate Mapping, Ablation and Mutagenesis of Microglia in the Mouse Brain -- Chapter 5: Technological Innovations: Progress of the Structural and Functional in vivo Imaging of Microglia -- PART II: Basic Discoveries in Physiology -- Chapter 6:Microglial Physiology: Receptors -- Chapter 7: Microglial Physiology: Calcium Signalling -- Chapter 8:Contactomics of Microglia and Intercellular Communication -- Chapter 9: Elimination of Neurones: Embryonic and Postnatal Development -- Chapter 10: Developmental Angiogenesis, Astrogliogenesis, and Myelination -- Chapter 11: Synaptic Formation and Elimination -- Chapter 12: Synaptic Maturation, Activity, and Plasticity -- Chapter 13: Adult Neurogenesis, Learning and Memory -- Chapter 14: Regulation of Sleep and Wakefulness -- PART III: General Pathophysiology of Microglia -- Chapter 15: Roles in Innate Immunity -- Chapter 16: Microglia and Systemic Immunity -- Chapter 17: Microglia and Microbiome-Gut-Brain Axis -- Chapter 18: Stress and Microglia: A Double-Edged Relationship -- Chapter 19: Substance Use and Addiction -- Chapter 20: Microglia and Sleep Disorders -- Chapter 21: Ageing -- Part IV: Microglia and Pathophysiology of Diseases of Nervous System -- Chapter 22: Neuropathic Pain -- Chapter 23: Role of Microglia in Stroke -- Chapter 24: Infectious Diseases including COVID-19 and HAND -- Chapter 25: Microglia and Multiple Sclerosis -- Chapter 26: Neurodevelopmental and Neuropsychiatric Disorders -- Chapter 27: Neurodegenerative Diseases -- Chapter 28: Microglia in Glioma -- PART V: Clinical Potential -- Chapter 29: Microglial Risk Alleles for Neurodegenerative Diseases (GWAS studies) -- Chapter 30: Emerging Models for the Study of Human Microglia in vitro (e.g. IPSCs, minibrains) -- Chapter 31: Emerging Models for the Study of Human Microglia ex vivo (comparison between human and rodent microglia) -- Chapter 32: Radiotracers for Microglial PET Imaging in vivo (focus on TSPO and its limitations) -- Chapter 33: Role of Microglial Modulation in Therapies for Perinatal Brain Injuries Leading to Neurodevelopmental Disorders -- Chapter 34: Metabolic Control of Microglial Function -- Chapter 35: Microglial Emerging Therapies and Targets under Clinical Trial -- Chapter 36: Epilogue. 330 $aThe past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these CNS diseases. 410 0$aAdvances in Neurobiology,$x2190-5223 ;$v37 606 $aNeurosciences 606 $aNeurology 606 $aImmunology 606 $aNeuroscience 606 $aNeurology 606 $aImmunology 615 0$aNeurosciences. 615 0$aNeurology. 615 0$aImmunology. 615 14$aNeuroscience. 615 24$aNeurology. 615 24$aImmunology. 676 $a616.80471 700 $aTremblay$b Marie-Ève$01769170 701 $aVerkhratsky$b Alexei$0917755 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910886079203321 996 $aMicroglia$94236922 997 $aUNINA