LEADER 04293nam 22006975 450 001 9910886066903321 005 20250505221048.0 010 $a3-031-64995-8 024 7 $a10.1007/978-3-031-64995-0 035 $a(MiAaPQ)EBC31642011 035 $a(Au-PeEL)EBL31642011 035 $a(CKB)34774643000041 035 $a(DE-He213)978-3-031-64995-0 035 $a(EXLCZ)9934774643000041 100 $a20240903d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRejuvenation and Longevity $eIntroduction to Rejuvenology /$fby Khachik K. Muradian, Vadim E. Fraifeld 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (133 pages) 225 1 $aHealthy Ageing and Longevity,$x2199-9015 ;$v20 311 08$a3-031-64994-X 327 $aIntroduction to optimistic gerontology -- The origin of life, immortality, and aging -- Cellular learning, decision-making, and rejuvenation -- Sporulation, meiosis and rejuvenation -- Longevity secrets of the three marine beauties?sponges, corals and sea anemones -- Metazoans who live longer than Jeanne Calment -- Transposable elements and rejuvenation of genome -- Embryonic stem cells and the ?last-minute? correction -- Muse cells and VSEL stem cells in longevity and rejuvenation -- The paradox of the adult stem cells: Relevance to aging and rejuvenation -- Biological age can be moved in both directions -- Rejuvenation is on its way. 330 $aThis book is a systematic collection and critical analysis of current information on rejuvenation, starting from the evolutionary aspects of the origin of life, immortality, and aging. Models, mechanisms, and types of rejuvenation are the key subjects of the book. Processes like cellular reprogramming, resetting of the aging clock, immortal unicellulars and cell cultures are explored through the lens of rejuvenation. Recent discoveries in this field offer a nuanced view of rejuvenation that has fascinated mankind since early history. There is evidence, though still controversial, indicating that biological time could be reversible. Indeed, under specific experimental conditions, cells can be moved back and forth along the age axis. Differentiation status and replicative age of cells can be modified not only by defined transcription factors, but also by ?cocktails? of small molecules originating from natural substances or well-known longevity-promoting drugs. Still in its infancy, such findings open up the perspective of in vivo rejuvenation trials. Special attention is given to the quasi-immortal and extremely long-lived multicellular animal species as well as to the role of rejuvenation in treatment of pathology and healthy aging. Rejuvenation is experiencing a significant growth in recent years. There is ample debate in the scientific and near-scientific community about the ethics of rejuvenation and radical life span extension. This book aims to take a balanced and scientific approach to the mirage of immortality and ever-lasting youth and serves as a valuable resource for parties on both sides of the coin. 410 0$aHealthy Ageing and Longevity,$x2199-9015 ;$v20 606 $aAging 606 $aStem cells 606 $aGeriatrics 606 $aCytology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aAgeing 606 $aStem Cell Biology 606 $aGeriatrics 606 $aCellular Senescence 606 $aBiomedical Research 615 0$aAging. 615 0$aStem cells. 615 0$aGeriatrics. 615 0$aCytology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 14$aAgeing. 615 24$aStem Cell Biology. 615 24$aGeriatrics. 615 24$aCellular Senescence. 615 24$aBiomedical Research. 676 $a571.878 700 $aMuradi?a?n$b Kh. K$g(Khachik Kazarovich)$01817349 701 $aFraifeld$b Vadim E$01770041 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910886066903321 996 $aRejuvenation and Longevity$94375088 997 $aUNINA