LEADER 04421nam 22007095 450 001 9910879583503321 005 20250807153255.0 010 $a3-031-62131-X 024 7 $a10.1007/978-3-031-62131-4 035 $a(MiAaPQ)EBC31591920 035 $a(Au-PeEL)EBL31591920 035 $a(CKB)33769638300041 035 $a(DE-He213)978-3-031-62131-4 035 $a(EXLCZ)9933769638300041 100 $a20240808d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aOxidative Stress in Cardiovascular-Metabolic Diseases /$fedited by Ali Hussein Eid, Firas Kobeissy, Ahmed F. El-Yazbi 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (307 pages) 225 1 $aOxidative Stress in Applied Basic Research and Clinical Practice,$x2197-7232 311 08$a3-031-62130-1 327 $aChapter 1 - Interplay between ROS and gender in the pathogenesis of cardiovascular disease -- chapter 2 -ROS, aging and cardiovascular disease -- Chapter 3 - Combat ROS, prevent CVD -- Chapter 4 -Traumatic-brain injury and CVD: ROS is the link? -- Chapter 5 - Adipose tissue inflammation and CVD: oxidative stress as a catalyst -- Chapter 6 - Oxidative stress in diabetes-compounded CVD -- Chapter 7 - ROS in hypertension: a critical update -- Chapter 8 - ROS in atherosclerosis: what we know.-Chapter 9 - ROS as a key mediator of cardiovasculometabolic disease -- Chapter 10 - Antioxidant Therapy in CVD: hope or hype? -- Chapter 11 - Antioxidants as adjuvant therapy: Evidence from clinical trials. 330 $aThe book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis,diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective. This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies. 410 0$aOxidative Stress in Applied Basic Research and Clinical Practice,$x2197-7232 606 $aCytology 606 $aStress (Physiology) 606 $aCardiovascular system 606 $aPhysiology 606 $aMetabolism 606 $aMolecular biology 606 $aCellular Stress 606 $aCell Biology 606 $aCardiovascular Physiology 606 $aMetabolism 606 $aMolecular Biology 615 0$aCytology. 615 0$aStress (Physiology) 615 0$aCardiovascular system. 615 0$aPhysiology. 615 0$aMetabolism. 615 0$aMolecular biology. 615 14$aCellular Stress. 615 24$aCell Biology. 615 24$aCardiovascular Physiology. 615 24$aMetabolism. 615 24$aMolecular Biology. 676 $a571.6 700 $aEid$b Ali Hussein$01765113 701 $aKobeissy$b Firas$01743762 701 $aEl-Yazbi$b Ahmed F$01765114 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910879583503321 996 $aOxidative Stress in Cardiovascular-Metabolic Diseases$94206353 997 $aUNINA