LEADER 05184nam 2200613Ia 450 001 9910877873003321 005 20230607221243.0 010 $a1-281-76416-7 010 $a9786611764166 010 $a3-527-61350-1 010 $a3-527-61351-X 035 $a(CKB)1000000000376610 035 $a(EBL)482091 035 $a(SSID)ssj0000125233 035 $a(PQKBManifestationID)11144350 035 $a(PQKBTitleCode)TC0000125233 035 $a(PQKBWorkID)10026204 035 $a(PQKB)11628749 035 $a(MiAaPQ)EBC482091 035 $a(OCoLC)184983868 035 $a(EXLCZ)991000000000376610 100 $a20000729e20011999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCombinatorial chemistry $esynthesis, analysis, screening /$fedited by Gu?nther Jung 210 $aWeinheim ;$aNew York $cWiley-VCH$d2001, c1999 215 $a1 online resource (635 p.) 300 $aDescription based upon print version of record. 311 $a3-527-29869-X 320 $aIncludes bibliographical references and index. 327 $aCombinatorial Chemistry; Contents; 1. Combinatorial Chemistry; 1.1 Introduction; 1.2 Principles of Combinatorial Chemistry; 1.3 Methods and Techniques of Combinatorial Synthesis; 1.3.1 Synthetic Strategies Towards Combinatorial Libraries; 1.3.1.1 Split-Pool Synthesis Towards Combinatorial Libraries; 1.3.1.2 Parallel Synthesis Towards Combinatorial Libraries; 1.3.1.3 Reagent Mixture Synthesis Towards Combinatorial Libraries; 1.3.2 Synthetic Methodology for Organic Library Construction; 1.3.2.1 Solid-Phase Organic Synthesis; 1.3.2.2 Synthesis in Solution and Liquid-Phase Synthesis 327 $a1.4 Characterization of Combinatorial Libraries1.4.1 Analytical Characterization; 1.4.1.1 Analytical Characterization of Compound Mixtures; 1.4.1.2 Analytical Characterization of Single Substances; 1.4.2 Hit Identification in Combinatorial Libraries by High-Throughput Screening; 1.4.2.1 Strategies for Libraries of Compound Mixtures; 1.4.2.2 Strategies for Libraries of Separate Single Compounds; 1.5 Automation and Data Processing; 1.5.1 Synthesis Automation and Data Processing; 1.5.2 Automated Purification; 1.6 Library Design and Diversity Assessment 327 $a1.6.1 Diversity Assessment for Selection of Building Blocks or Compounds1.6.2 Iterative Optimization Methods; 1.7 Economic Aspects; 1.8 Acknowledgements; 1.9 References; 2. Survey of Solid-Phase Organic Reactions; 2.1 Introduction; 2.2 Observed Trends; 2.2.1 The Synthetic Repertoire; 2.2.1.1 Robust, Reliable Solid-Phase Reactions; 2.2.1.2 Emerging Solid-Phase Reactions; 2.2.2 Linkers and Cleavage Step; 2.2.3 Reaction-Monitoring; 2.2.4 Highlights; 2.3 Conclusions; 2.4 Reaction Tables; 2.4.1 Substitution Nucleophilic and Electrophilic Type of Reaction: Amide Bond Formation and Related Reactions 327 $a2.4.1.1 Sulphonamide2.4.1.2 (Thio)urea; 2.4.1.3 Carbonate; 2.4.1.4 Urethane; 2.4.1.5 Guanidine; 2.4.1.6 Imide; 2.4.1.7 Amide; 2.4.1.8 Lactam; 2.4.2 Type of Reaction: Aromatic Substitution; Electrophilic Carbon-Carbon Bond Formation; 2.4.2.1 Suzuki; 2.4.2.2. Stille; 2.4.2.3 Heck; 2.4.2.4 Other; 2.4.3 Type of Reaction: Aromatic Substitution; Nucleophilic (N-Arylation); 2.4.4 Type of Reaction: Cleavage; 2.4.4.1 Cyclative Cleavage; 2.4.4.2 Functional Group: None (traceless); 2.4.4.3 Functional Group: Halogens; 2.4.4.4 Functional Group: Alkenes; 2.4.4.5 Functional Group: Alcohols, Phenols 327 $a2.4.4.6 Functional Group: Primary Amine2.4.4.7 Functional Group: sec-Amine; 2.4.4.8 Functional Group: tert-Amine; 2.4.4.9 Functional Group: Aldehyde/Ketone; 2.4.4.10 Functional Group: Hydroxamic Acid; 2.4.4.11 Functional Group: Amidine; 2.4.4.12 Functional Group: Guanidine; 2.4.4.13 Functional Group: sec Amideltert Amide/Sulfonamide; 2.4.5 Type of Reaction: Condensation; 2.4.6 Type of Reaction: Cycloaddition; 2.4.6.1 [2+2] Cycloaddition; 2.4.6.2 [3+2] Cycloaddition; 2.4.6.3 [4+2] Cycloaddition; 2.4.7 Type of Reaction: Grignard and Related Reactions 327 $a2.4.8 Type of Reaction: Heterocycle Formation 330 $aThe story of success goes on and on - with a new book on combinatorial chemistry, edited by G?nther Jung!Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosacc 606 $aCombinatorial chemistry 606 $aOrganic compounds$xSynthesis 615 0$aCombinatorial chemistry. 615 0$aOrganic compounds$xSynthesis. 676 $a547.2 676 $a615.19 701 $aJung$b Gu?nther$094102 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877873003321 996 $aCombinatorial chemistry$92226372 997 $aUNINA