LEADER 05158nam 22006494a 450 001 9910877859503321 005 20200520144314.0 010 $a1-280-55981-0 010 $a9786610559817 010 $a3-527-60343-3 010 $a3-527-61638-1 035 $a(CKB)1000000000375897 035 $a(EBL)481871 035 $a(SSID)ssj0000307218 035 $a(PQKBManifestationID)11263795 035 $a(PQKBTitleCode)TC0000307218 035 $a(PQKBWorkID)10243798 035 $a(PQKB)10124203 035 $a(MiAaPQ)EBC481871 035 $a(PPN)137629486 035 $a(OCoLC)85820730 035 $a(EXLCZ)991000000000375897 100 $a20060821d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aProtein synthesis and ribosome structure $etranslating the genome /$fedited by Knud H. Nierhaus and Daniel N. Wilson 210 $aWeinheim $cWiley-VCH$dc2004 215 $a1 online resource (599 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30638-2 320 $aIncludes bibliographical references and index. 327 $aProtein Synthesis and Ribosome Structure; Contents; Preface; 1 A History of Protein Biosynthesis and Ribosome Research; 1.1 Introduction; 1.2 The Archaeology of Protein Synthesis - The 1940s: Forgotten Paradigms; 1.3 Basic Mechanisms - The 1950s; 1.3.1 Steps toward an in vitro Protein Synthesis System; 1.3.2 Amino Acid Activation and the Emergence of Soluble RNA; 1.3.3 From Microsomes to Ribosomes; 1.3.4 Models; 1.4 The Golden Age of Translation - The 1960s; 1.4.1 From Enzymatic Adaptation to Gene Regulation: Messenger RNA 327 $a1.4.2 A Bacterial in vitro System of Protein Synthesis and the Cracking of the Genetic Code1.4.3 The Functional Dissection of Translation; 1.4.4 The Structural Dissection of the Ribosome; 1.5 1970-1990s: A Brief Synopsis; References; 2 Structure of the Ribosome; 2.1 General Features of the Ribosome and Ribosomal Subunits; 2.2 A Special Feature of the 50S Subunit: The Tunnel; 2.3 Features of the Ribosomal Subunits at Atomic Resolution; 2.4 The Domain Structure of the Ribosomal Subunits 327 $a2.5 Interactions of RNA with RNA or Struts and Bolts in the Three-dimensional Fold of rRNA: Coaxial Stacking and A-minor Motifs2.5.1 Coaxial Stacking; 2.5.2 A-minor Motifs; 2.5.3 Ribose Zippers and Patches of A-minor Motifs; 2.5.3.1 Canonical Ribose Zipper; 2.5.3.2 Single-base Ribose Zipper; 2.6 Progress and New Developments in Understanding rRNA Structures; 2.6.1 K-turn; 2.6.2 Lonepair Triloop; 2.6.2.1 Classification of Lonepair Triloops; 2.6.3 Systemizing Base Pairs; 2.6.4 Systemizing RNA Structural Elements; 2.7 RNA-protein Interactions; 2.7.1 Problem of RNA Recognition 327 $a2.7.2 Chemistry of RNA-protein Interactions2.7.3 rRNA-protein Interaction; References; 3 Ribosome Assembly; 3.1 Assembly Of The Prokaryotic Ribosome; 3.1.1 Introduction; 3.1.2 Processing of rRNAs; 3.1.3 Precursor Particles and Reconstitution Intermediates; 3.1.4 Assembly-initiator Proteins; 3.1.5 Proteins Essential for the Early Assembly: The Assembly Gradient; 3.1.6 Late-assembly Components; 3.1.7 Proteins Solely Involved in Assembly; 3.1.8 Assembly Maps; References; 3.2 Eukaryotic Ribosome Synthesis; 3.2.1 Introduction; 3.1.1 Prelude; 3.2.2 Why so many RRPs? 327 $a3.2.3 (Pre-)ribosome Assembly, the Proteomic Era3.2.4 Ribosomal RNA Processing, Getting there...; 3.2.5 Ribosomal RNA Modification: A Solved Issue?; 3.2.5.1 Ribose Methylation, Pseudouridines formation and the snoRNAs; 3.2.5.2 The Emergence of the snoRNAs; 3.2.5.3 Non-ribosomal RNA Substrates for the snoRNAs; 3.2.5.4 Possible function(s) of RNA modifications; 3.2.5.5 Base methylation; 3.2.5.6 U3 snoRNP, the 'SSU Processome', and the Central Pseudoknot; 3.2.6 SnoRNA Synthesis and Intranuclear Trafficking; 3.2.6.1 SnoRNAs Synthesis 327 $a3.2.6.2 Non-core snoRNP Proteins required for snoRNA Accumulation 330 $aKnud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology.In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier 606 $aRibosomes 606 $aRibosomes$xStructure 606 $aProteins$xSynthesis 615 0$aRibosomes. 615 0$aRibosomes$xStructure. 615 0$aProteins$xSynthesis. 676 $a572/.645 701 $aNierhaus$b Knud H$01761606 701 $aWilson$b Daniel N$01761607 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877859503321 996 $aProtein synthesis and ribosome structure$94201181 997 $aUNINA