LEADER 04359nam 2200661Ia 450 001 9910877717103321 005 20200520144314.0 010 $a1-280-52066-3 010 $a9786610520664 010 $a3-527-60566-5 010 $a3-527-60178-3 035 $a(CKB)1000000000019353 035 $a(EBL)481536 035 $a(OCoLC)68932384 035 $a(SSID)ssj0000246906 035 $a(PQKBManifestationID)11186333 035 $a(PQKBTitleCode)TC0000246906 035 $a(PQKBWorkID)10188583 035 $a(PQKB)11192449 035 $a(MiAaPQ)EBC481536 035 $a(EXLCZ)991000000000019353 100 $a20020920d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSmall molecule DNA and RNA binders $efrom synthesis to nucleic acid complexes /$fM. Demeunynck, C. Bailly, W. D. Wilson (eds.) 210 $aWeinheim $cWiley-VCH$dc2003 215 $a1 online resource (756 p.) 300 $aDescription based upon print version of record. 311 $a3-527-30595-5 320 $aIncludes bibliographical references and index. 327 $aSmall Molecule DNA and RNA Binders; Contents; Preface; Contributors; 1 Forty Years On; 1.1 Early Experiments Prior to Molecular Modeling; 1.2 Formulation of Molecular Models and Mechanisms of Binding to DNA; 1.3 Specificity of Nucleotide Sequence Recognition; 1.4 Details at the Atomic and Molecular Levels; 1.5 Identification of Motifs for Drug Design; 1.6 Actions on Nucleoproteins, Chromatin, and Enzymes; References; 2 Targeting HIV RNA with Small Molecules; 2.1 Introduction; 2.1.1 Translation; 2.1.2 RNA Viruses; 2.2 Small Molecules that Modulate RNA Activity; 2.2.1 Magnesium (II) 327 $a2.2.2 Aminoglycosides2.2.3 Ligand Specificity; 2.2.4 Goals; 2.3 The RRE and HIV Replication; 2.4 Determination of RRE-Ligand Affinity and Specificity; 2.4.1 Fluorescence Anisotropy; 2.4.2 Solid-phase (Affinity-Displacement) Assay; 2.4.3 Ethidium Bromide Displacement; 2.5 New RRE Ligands; 2.5.1 Neomycin-Acridine Conjugates; 2.5.2 Dimeric Aminoglycosides; 2.5.3 Guanidinoglycosides; 2.6 Conclusions; Acknowledgments; References; 3 RNA Targeting by Bleomycin; 3.1 Activation of Bleomycin for Polynucleotide Degradation; 3.2 Bleomycin-mediated Cleavage of Transfer RNAs and tRNA Precursor Transcripts 327 $a4.6 Combinatorial Library Approach in the Discovery of Small Molecule Drugs Targeting RNA4.6.1 Combinatorial Chemistry; 4.6.2 Split Synthesis; 4.6.3 Encoding; 4.6.4 On-bead Screening and Identification of Structure-specific TAR-Binding Ligands; 4.6.5 Ligand Sequence Analysis; 4.6.6 Heterochiral Small Molecules Target TAR RNA Bulge; 4.6.7 Inhibition of Tat trans-Activation in vivo; 4.7 Cyclic Structures as RNA-targeting Drugs; 4.8 Summary and Perspective; Acknowledgments; References; 5 DNA and RNA Recognition and Modification by Gly-Gly-His-Derived Metallopeptides; 5.1 Introduction 327 $a5.2.3.5 Guanine nucleobase modification/oxidation 330 $aThe development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end st 517 3 $aDNA and RNA binders : from small molecules to drugs 606 $aDNA-drug interactions 606 $aMolecular biology 606 $aBinding sites (Biochemistry) 606 $aNucleic acids 615 0$aDNA-drug interactions. 615 0$aMolecular biology. 615 0$aBinding sites (Biochemistry) 615 0$aNucleic acids. 676 $a572.8 701 $aDemeunynck$b M$g(Martine)$01760611 701 $aBailly$b Christian$01760612 701 $aWilson$b W. D$g(W. David)$01760613 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877717103321 996 $aSmall molecule DNA and RNA binders$94199658 997 $aUNINA