LEADER 05320nam 22006134a 450 001 9910877417003321 005 20200520144314.0 010 $a1-280-19706-4 010 $a9786610197064 010 $a0-470-76256-X 010 $a0-470-98866-5 010 $a1-4051-4391-6 035 $a(CKB)1000000000341873 035 $a(EBL)233013 035 $a(SSID)ssj0000117840 035 $a(PQKBManifestationID)11117219 035 $a(PQKBTitleCode)TC0000117840 035 $a(PQKBWorkID)10052622 035 $a(PQKB)10981883 035 $a(MiAaPQ)EBC233013 035 $a(OCoLC)184983432 035 $a(EXLCZ)991000000000341873 100 $a20041208d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCardiovascular development and congenital malformations $emolecular and genetic machanisms [sic] /$fedited by Michael Artman ... [et al.] ; foreword by Atsuyoshi Takao, Edward B. Clark 210 $aMalden, Mass. $cBlackwell Futura$d2005 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-3128-4 320 $aIncludes bibliographical references and index. 327 $aCardiovascular Development and Congenital Malformations : Molecular & Genetic Mechanisms; Contents; Foreword; Contributors; PART 1: Establishing left-right patterning and cardiac looping; Editorial perspective; 1. Microenvironment provides left-right instructions to migrating precardiac mesoderm; 2. Calmodulin-inv protein interaction and left-right determination; 3. Misexpression of upstream laterality genes on downstream mechanisms of heart looping: a flectin perspective; 4. Pleiotropic effects of Pitx2 isoform c on morphogenesis in the mammalian heart 327 $a5. Signal transduction during cardiac myofibrillogenesis and looping6. Biological role of fibulin-2 in cardiovascular development; PART 2: Mechanisms of cardiogenesis and myocardial development; Editorial perspective; 7. TBX5 regulates cardiac cell behavior during cardiogenesis; 8. Cardiac homeobox protein Csx/Nkx2.5 and its associated proteins; 9. Regulation of myocardium formation after the initial development of the linear heart tube; 10. The role of the extracellular matrix (ECM) in cardiac development; 11. Teratogenic effects of bis-diamine on the developing myocardium 327 $a12 Proliferative responses to myocardial remodeling in the developing heartPART 3: Formation of endocardial cushions and valves; Editorial perspective; 13. TGFB signaling during atrioventricular cushion transformation; 14. The endocardium as a unique modulator of in utero cardiovascular form and function; 15. Valvulogenesis: role of periostin in cushion tissue differentiation; 16. Role of fibroblast growth factors in early valve leaflet formation; 17. Msx1 expression during chick heart development: possible role in endothelial-mesenchymal transformation during cushion tissue formation 327 $aPART 4: Segment and chamber specificationEditorial perspective; 18. Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis; 19. Transcriptional regulation of ventricular morphogenesis; 20. Fgf10 and the embryological origin of outflow tract myocardium; 21. Evolutionary conservation of atrial natriuretic factor (Anf) expression, cardiac chamber formation, and the heart-forming region; PART 5: Formation of specialized conduction tissues; Editorial perspective; 22. Induction and patterning of the impulse conducting Purkinje fiber network 327 $a23. Spatial correlation of conduction tissue in the ventricular trabeculae of the developing zebrafish24. Development of the cardiac conduction system and contribution of neural crest and epicardially derived cells; 25. The development of the cardiac conduction system: an old story with a new perspective; 26. The role of calreticulin in cardiac development and function; PART 6: Coronary artery development; Editorial perspective; 27. Development of proximal coronary artery in quail embryonic heart; 28. Possible roles of the extracellular matrix in coronary vasculogenesis of mouse 327 $a29. Abnormal coronary development in bis-diamine treated embryo 330 $aCongenital cardiovascular malformations are the single most common form of birth defect. Therefore a better understanding of the mechanisms involved in both normal cardiac development and the formation of cardiovascular structural defects is of tremendous importance.This book brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases. A broad variety of approaches, techniques, experimental models and studies of human genetics combine to make this a truly outstanding 606 $aHeart$xAbnormalities 606 $aHeart$xGrowth 615 0$aHeart$xAbnormalities. 615 0$aHeart$xGrowth. 676 $a616.1/2043 701 $aArtman$b Michael$f1952-$0888192 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877417003321 996 $aCardiovascular development and congenital malformations$91984055 997 $aUNINA