LEADER 05379nam 2200661Ia 450 001 9910877403103321 005 20200520144314.0 010 $a1-282-13817-0 010 $a9786612138171 010 $a0-470-74355-7 010 $a0-470-74356-5 035 $a(CKB)1000000000719723 035 $a(EBL)427972 035 $a(OCoLC)437111545 035 $a(SSID)ssj0000354170 035 $a(PQKBManifestationID)11277468 035 $a(PQKBTitleCode)TC0000354170 035 $a(PQKBWorkID)10302772 035 $a(PQKB)10891865 035 $a(MiAaPQ)EBC427972 035 $a(PPN)152565043 035 $a(EXLCZ)991000000000719723 100 $a20081231d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe epigenetics of autoimmune diseases /$fedited by Moncef Zouali 210 $aChichester ;$aHoboken, NJ $cWiley-Blackwell$d2009 215 $a1 online resource (473 p.) 300 $aDescription based upon print version of record. 311 $a0-470-75861-9 320 $aIncludes bibliographical references and index. 327 $aThe Epigenetics of Autoimmune Diseases; Contents; Preface; Contributors; PART I Transcription Factors: Partners of Immune Tolerance to Self; 1 Transcriptional regulation of T cell tolerance; 1.1 Introduction; 1.2 T cell anergy; 1.3 Ca2+/calcineurin/NFAT signalling in T cell anergy; 1.4 Transcriptional programme of T cell anergy; 1.5 Transcriptional repression in T cell anergy: epigenetic modification of the Il2 promoter; 1.6 Regulatory T cells; 1.7 Transcriptional control of Treg development and function; References; 2 Epigenetic regulation of Foxp3 expression in regulatory T cells 327 $a2.1 Introduction2.2 Naturally occurring CD25+ CD4+ Tregs; 2.3 The transcription factor FOXP3: determining Treg function and identity; 2.4 Molecular regulation of FOXP3; 2.5 Tregs as a stable lineage: indications of epigenetic imprinting; 2.6 Induced Tregs: stable suppressors or transient immuno-modulators?; 2.7 Conclusions; References; 3 The role of NF-kB in central tolerance; 3.1 Introduction; 3.2 Canonical and alternative NF-kB pathways; 3.3 Thymic stroma and central tolerance; 3.4 NF-kB and regulatory T cell development; 3.5 NF-kB and thymocyte positive and negative selection 327 $a3.6 Conclusions and perspectives3.7 Acknowledgement; References; 4 The role of Act1 in the control of autoimmunity; 4.1 Introduction; 4.2 Autoimmunity and autoimmune mouse models; 4.3 Molecular mechanisms of autoimmunity; 4.4 Act1: a modulator of autoimmunity; 4.5 Conclusions; References; 5 Regulation of T cell anergy and escape from regulatory T cell suppression by Cbl-b; 5.1 Introduction; 5.2 Mechanisms of T cell tolerance induction; 5.3 Molecular establishment of T cell anergy; 5.4 Ubiquitin E3 ligases in T cell tolerance; 5.5 Molecular function and regulation of Cbl-b 327 $a5.6 Physiological relevance of Cbl-b5.7 The role of Cbl-b in T cell tolerance; 5.8 Deregulation of Cbl-b in disease; 5.9 Therapeutic potential of Cbl-b in tumour immunity; 5.10 Implications for autoimmune disease; References; 6 Indoleamine 2,3-dioxygenase: transcriptional regulation and autoimmunity; 6.1 Introduction; 6.2 L-Trp degradation along the kynurenine pathway and immune functions of IDO; 6.3 IDO immunobiology and therapeutic intervention; 6.4 Transcriptional regulation of the IDO-encoding gene; 6.5 Impaired IDO activity and loss of tolerance in autoimmune diseases 327 $a6.6 IDO-based therapies for autoimmune disease6.7 Acknowledgement; References; PART II Stress Responses that Break Immune Silence; 7 Chromatin modifications, oxidative stress and nucleosome autoantibodies; 7.1 Introduction; 7.2 Nucleosome and SLE; 7.3 Epigenetics and SLE; 7.4 Oxidative stress in SLE: definition and mechanisms; 7.5 Oxidative stress, epigenetic alterations and nucleosome immunogenicity; 7.6 Conclusion; 7.7 Acknowledgements; References; 8 Stress, epigenetics and thyroid autoimmunity; 8.1 Introduction; 8.2 The Th1/Th2 balance in immune-response regulation 327 $a8.3 Stress hormones and the Th1/Th2 balance 330 $aThe role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes:How highly developed epigenetic mechanisms are involved in several aspec 606 $aAutoimmunity$xMolecular aspects 606 $aAutoimmune diseases$xEtiology 606 $aPost-translational modification 606 $aEpigenesis 615 0$aAutoimmunity$xMolecular aspects. 615 0$aAutoimmune diseases$xEtiology. 615 0$aPost-translational modification. 615 0$aEpigenesis. 676 $a571.9/73 701 $aZouali$b Moncef$f1952-$01328962 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877403103321 996 $aThe epigenetics of autoimmune diseases$94184580 997 $aUNINA