LEADER 11582nam 22005773 450 001 9910877346203321 005 20240529080233.0 010 $a9783527840397 010 $a3527840397 010 $a9783527840380 010 $a3527840389 010 $a9783527840373 010 $a3527840370 035 $a(CKB)32138130200041 035 $a(MiAaPQ)EBC31354775 035 $a(Au-PeEL)EBL31354775 035 $a(Exl-AI)31354775 035 $a(EXLCZ)9932138130200041 100 $a20240529d2024 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aApplied Metallomics $eFrom Life Sciences to Environmental Sciences 205 $a1st ed. 210 1$aNewark :$cJohn Wiley & Sons, Incorporated,$d2024. 210 4$dİ2024. 215 $a1 online resource (499 pages) 311 08$a9783527351442 311 08$a3527351442 327 $aCover -- Title Page -- Copyright -- Contents -- Foreword -- Preface -- Chapter 1 Introduction -- 1.1 A Brief Introduction to Metallomics -- 1.2 Key Issues and Challenges in Metallomics -- 1.3 About the Structure of this Book -- References -- Chapter 2 Nanometallomics -- 2.1 The Concept of Nanometallomics -- 2.2 The Analytical Techniques in Nanometallomics -- 2.2.1 The Analytical Techniques for Size Characterization of Nanomaterials in Biological System -- 2.2.1.1 Chromatography?based Techniques for Size Characterization -- 2.2.1.2 Mass?spectrometry?based Techniques for Size Characterization -- 2.2.1.3 Laser, X?rays, and Neutron?beam?based Techniques for Size Characterization -- 2.2.2 The Analytical Techniques for Quantification of Nanomaterials and Metallome in Biological System -- 2.2.3 The Analytical Techniques for Studying the Distribution of Nanomaterials in Biological System -- 2.2.4 The Analytical Techniques for Studying the Metabolism of Nanomaterials in Biological System -- 2.3 The Application of Nanometallomics in Nanotoxicology -- 2.3.1 Understanding the Size Changes, Uptake and Excretion, Distribution, and Metabolism of Nanomaterials in Biological Systems -- 2.3.2 Comparative Nanometallomics for Distinguishing Nanomaterials Exposure and Nanosafety Evaluation -- 2.4 Conclusions and Perspectives -- Acknowledgments -- References -- Chapter 3 Environmetallomics -- 3.1 The Concept of Environmetallomics -- 3.2 The Analytical Techniques in Environmetallomics -- 3.2.1 The Requirements for Environmetallome Analysis -- 3.2.2 Quantitative Analysis for Environmetallomics -- 3.2.3 Metal Distribution and Mapping for Environmetallomics -- 3.2.4 Metal Speciation for Environmetallomics -- 3.2.5 Metalloprotein Analysis -- 3.3 The Application of Environmetallomics in Environmental Science and Ecotoxicological Science and the Perspectives. 327 $aAcknowledgments -- References -- Chapter 4 Agrometallomics -- 4.1 The Concept of Agrometallomics -- 4.1.1 Introduction -- 4.1.2 Agrometallomics and its Concept -- 4.2 Analytical Techniques in Agrometallomics -- 4.2.1 Sensitivity and Multi?elemental Analysis in Agrometallomics -- 4.2.1.1 Mass Spectrometry in Agrometallomics -- 4.2.1.2 Atomic Spectrometry for Agrometallomics -- 4.2.2 Elemental Speciation and State Analysis in Agrometallomics -- 4.2.2.1 Chromatographic Hyphenation for Atomic Spectrometry or Mass Spectrometry -- 4.2.2.2 Synchrotron Radiation Analysis -- 4.2.2.3 Energy Spectroscopy Based on X?ray -- 4.2.3 Spatial Distribution and Micro?analysis Techniques in Agrometallomics -- 4.2.3.1 Laser Ablation Inductively Coupled Plasma Mass Spectrometry -- 4.2.3.2 Electrothermal Vaporization Hyphenation Technique -- 4.2.3.3 Laser?induced Breakdown Spectroscopy -- 4.2.3.4 Single?Cell and Micro?particle Analysis -- 4.3 Application and Perspectives of Agrometallomics in Agricultural Science and Food Science -- 4.3.1 Agricultural Plants and Fungi and Derived Food -- 4.3.2 Agricultural Animal and Derived Food -- 4.3.2.1 Application of Sensitivity and Multielemental Analysis in Agricultural Animals -- 4.3.2.2 Application of Elemental Speciation and State Analysis in Agricultural Animals -- 4.3.2.3 Application of Spatial Distribution and Micro?analysis in Agricultural Animals -- 4.3.3 Soil, Water, and Fertilizer for Agriculture -- References -- Chapter 5 Metrometallomics -- 5.1 The Concept of Metrometallomics -- 5.2 The Analytical Techniques in Metrometallomics -- 5.2.1 Analytical Techniques of Protein Quantification in Metrometallomics -- 5.2.2 Analytical Techniques of Quantitative In Situ Analysis in Metrometallomics -- 5.3 The Application of Metrometallomics in Life Science and the Perspectives. 327 $a5.3.1 Absolute Quantification of Metalloproteins in Metrometallomics -- 5.3.1.1 Naturally Present Elements (P, S, Se, Metals) -- 5.3.1.2 Elemental Labeling -- 5.3.1.3 Directly Protein Tagging (I, Hg, Chelate Complexes) -- 5.3.1.4 Immunological Tagging -- 5.3.1.5 Direct Quantification of Proteins by LA?ICP?MS -- 5.3.1.6 Calibration for Metalloprotein Quantification by ICP?MS -- 5.3.1.7 Perspectives of Absolute Quantification of Metalloproteins -- 5.3.2 Calibration Strategies of Quantitative In Situ Analysis in Metrometallomics -- 5.3.2.1 Internal Standardization -- 5.3.2.2 External Calibration -- 5.3.2.3 Calibration by Isotope Dilution -- 5.3.2.4 Perspectives of Quantitative In Situ Analysis in Metrometallomics -- Acknowledgments -- References -- Chapter 6 Medimetallomics and Clinimetallomics -- 6.1 The Concept of Medimetallomics and Clinimetallomics -- 6.1.1 Medimetallomics -- 6.1.2 Clinimetallomics -- 6.2 The Analytical Techniques in Medimetallomics and Clinimetallomics -- 6.2.1 Total Analysis of Clinical Elements -- 6.2.1.1 Atomic Spectroscopy Detection Technology -- 6.2.1.2 Mass Detection Technology -- 6.2.1.3 Electrochemical Analysis -- 6.2.1.4 Neutron Activation Analysis -- 6.2.2 Clinical Element Morphology and Valence Analysis Technology -- 6.2.2.1 Atomic Spectroscopy Detection Technology -- 6.2.2.2 Mass Spectrometry Detection Technology -- 6.2.3 Summary and Outlook -- 6.3 The Application of Medimetallomics and Clinimetallomics in Medical and Clinical Science and the Perspectives -- 6.3.1 Medimetallomics -- 6.3.1.1 Global or National Medimetallomics Research -- 6.3.1.2 Standardized Protocol for Medimetallomics Research -- 6.3.1.3 The Application of Medimetallomics Results -- 6.3.1.4 Next Steps and Opportunities for Medimetallomics -- 6.3.2 Clinimetallomics -- 6.3.2.1 Diseases Associated with Trace Elements. 327 $a6.3.2.2 Toxic?Element?Related Diseases -- 6.3.2.3 Combined Toxicity of Multiple Heavy Metal Mixtures -- 6.3.2.4 Genetic Diseases Associated with Metallomics -- 6.3.2.5 Application of Metallomics in Disease Treatment -- 6.3.2.6 Perspectives -- References -- Chapter 7 Matermetallomics -- 7.1 The Concept of Matermetallomics -- 7.1.1 Introduction -- 7.1.2 Metallic Elements as Dopant -- 7.1.3 Metallic Elements as Impurities -- 7.1.4 Metallic Elements as Crosslinkers -- 7.2 The Analytical Techniques in Matermetallomics -- 7.2.1 Element Imaging Analysis -- 7.2.1.1 Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA?ICP?MS) -- 7.2.1.2 Laser?Induced Breakdown Spectroscopy (LIBS) -- 7.2.1.3 Secondary Ion Mass Spectrometry (SIMS) -- 7.2.1.4 TEM/X?EDS -- 7.2.1.5 Synchrotron Radiation X?Ray Fluorescence Spectrometry (SR?XRF) -- 7.2.2 Quantitative and Qualitative Analysis -- 7.2.2.1 Inductively Coupled Plasma Atomic Emission Spectrometry (ICP?AES) -- 7.2.2.2 Inductively Coupled Plasma Mass Spectrometry (ICP?MS) -- 7.2.2.3 X?Ray Fluorescence (XRF) -- 7.2.2.4 GD Optical Emission Spectroscopy (GD?OES) and GD Mass Spectrometry (GD?MS) -- 7.2.3 Metal Speciation Analysis -- 7.2.3.1 Raman Spectroscopy -- 7.2.3.2 X?Ray Photo Electron Spectroscopy (XPS) -- 7.2.4 Techniques Providing Depth Information -- 7.3 The Application of Matermetallomics in Material Science and the Perspectives -- 7.3.1 Matermetallomics in Semiconductor Materials -- 7.3.2 Matermetallomics in Artificial Crystal Materials -- Acknowledgments -- References -- Chapter 8 Archaeometallomics -- 8.1 The Concept of Archaeometallomics -- 8.2 The Analytical Techniques in Archaeometallomics -- 8.2.1 Neutron Activation Analysis (NAA) -- 8.2.2 X?Ray Fluorescence Analysis (XRF) -- 8.2.3 Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA?ICP?MS). 327 $a8.2.4 Laser?induced Breakdown Spectroscopy (LIBS) -- 8.2.5 Atomic Absorption Spectroscopy (AAS) -- 8.2.6 X?Ray Absorption Fine Structure Spectroscopy (XAFS) -- 8.2.7 X?Ray Diffraction (XRD) -- 8.2.8 Neutron Diffraction -- 8.3 The Application of Archaeometallomics in Archaeological Science -- 8.3.1 The Application of Archaeometallomics in Ancient Ceramics -- 8.3.1.1 Archaeometallomics in Studying the Origin and Dating of Ancient Ceramics -- 8.3.1.2 Archaeometallomics in Studying the Color Mechanism and Firing Technology of Ancient Ceramics -- 8.3.2 The Application of Archaeometallomics in Metal Cultural Relics -- 8.3.2.1 Archaeometallomics in Studying the Origin of Metal Cultural Relics -- 8.3.2.2 Archaeometallomics in Studying the Manufacturing Technology of Metal Cultural Relics -- 8.3.2.3 Archaeometallomics in Studying the Corrosion of Metal Cultural Relics -- 8.3.3 The Application of Archaeometallomics in Ancient Painting -- 8.3.3.1 Archaeometallomics in Studying the Aging Mechanism of Painting Cultural Relics -- 8.3.3.2 Archaeometallomics in Studying the Authenticity Identification of Painting Cultural Relics -- 8.4 Summary and Perspectives -- Acknowledgments -- References -- Chapter 9 Metallomics in Toxicology -- 9.1 Metallomic Research on the Toxicology of Metals -- 9.2 Recent Progresses in Understanding the Health Effects of Heavy Metals -- 9.2.1 Mercury, Oxidative Stress, and Cell Death -- 9.2.2 Arsenic and Lung Cancer -- 9.2.3 Epigenetic Effects of Cadmium -- 9.2.4 Nephrotoxicity of Uranium in Drinking Water -- 9.3 Knowledge Gaps, Challenges, and Perspectives -- Acknowledgments -- List of Abbreviations -- References -- Chapter 10 Pathometallomics: Taking Neurodegenerative Disease as an Example -- 10.1 Introduction to Pathometallomics -- 10.1.1 The Concept and Scope of Pathometallomics. 327 $a10.1.2 Brief Introduction to Methodologies for Pathometallomics. 330 $aApplied Metallomics: From Life Sciences to Environmental Sciences is a comprehensive examination of metallomics, an interdisciplinary field that explores the role of metals in biological systems. Edited by Yu-Feng Li and Hongzhe Sun, the book features contributions from experts in China, detailing methodologies, applications, and challenges in the field. It covers a wide range of topics including environmental science, toxicology, cancer studies, and data mining with machine learning. The book is geared towards scientists, researchers, and students who are involved or interested in the metallomics domain, providing insights into the integration of metallomics with other scientific fields and the use of advanced analytical techniques.$7Generated by AI. 606 $aMetals in the body$7Generated by AI 606 $aEnvironmental sciences$7Generated by AI 615 0$aMetals in the body 615 0$aEnvironmental sciences 700 $aLi$b Yu-Feng$01759669 701 $aSun$b Hongzhe$01727302 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877346203321 996 $aApplied Metallomics$94198273 997 $aUNINA