LEADER 03863nam 2200613Ia 450 001 9910877301103321 005 20200520144314.0 010 $a1-280-41117-1 010 $a9786610411177 010 $a0-470-03500-5 010 $a0-470-03499-8 035 $a(CKB)1000000000357399 035 $a(EBL)255723 035 $a(SSID)ssj0000245851 035 $a(PQKBManifestationID)11211418 035 $a(PQKBTitleCode)TC0000245851 035 $a(PQKBWorkID)10181220 035 $a(PQKB)10013973 035 $a(MiAaPQ)EBC255723 035 $a(OCoLC)86221676 035 $a(EXLCZ)991000000000357399 100 $a20050331d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSignalling pathways in acute oxygen sensing 210 $aChichester, UK ;$aHoboken, NJ $cJohn Wiley$d2006 215 $a1 online resource (302 p.) 225 1 $aNovartis Foundation symposium ;$v272 300 $aDescription based upon print version of record. 311 $a0-470-01457-1 320 $aIncludes bibliographical references and indexes. 327 $aCover; Contents; Chair's introduction; Regulation of gene expression by HIF-1; DISCUSSION; Regulation of HIF: prolyl hydroxylases; DISCUSSION; General discussion I; Regulation of HIF: asparaginyl hydroxylation; DISCUSSION; Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells; DISCUSSION; The role of TASK-like K+ channels in oxygen sensing in the carotid body; DISCUSSION; Reactive oxygen species facilitate oxygen sensing; DISCUSSION; Oxygen sensing in neuroepithelial and adrenal chromaffin cells; DISCUSSION 327 $aHypoxic regulation of Ca2+ signalling in astrocytes and endothelial cellsDISCUSSION; General discussion II; Functional proteomics of BK potassium channels: defining the acute oxygen sensor; DISCUSSION; A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system; DISCUSSION; Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction; DISCUSSION; Hypoxic pulmonary vasoconstriction-triggered by an increase in reactive oxygen species?; DISCUSSION; General discussion III 327 $aThe role of twin pore domain and other K+ channels in hypoxicpulmonary vasoconstrictionDISCUSSION; AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells; DISCUSSION; Role of capacitative Ca2+ entry but not Na+/Ca2+ exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries; DISCUSSION; Final general discussion; Index of contributors; Subject index 330 $aOxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mech 410 0$aNovartis Foundation symposium ;$v272. 606 $aOxygen in the body 606 $aOxygen 615 0$aOxygen in the body. 615 0$aOxygen. 676 $a572.53 676 $a573.1536 712 02$aNovartis Foundation. 712 12$aSymposium on Signalling Pathways in Acute Oxygen Sensing 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877301103321 996 $aSignalling pathways in acute oxygen sensing$94193069 997 $aUNINA