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010   $a9786612347719
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100   $a19910118d1991      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aHost-guest molecular interactions $efrom chemistry to biology
210   $aChichester ;$aNew York $cWiley$d1991
215   $a1 online resource (290 p.)
225 1 $aCiba Foundation symposium ;$v158
300   $aProceedings of the Symposium on Host-Guest Molecular Interactions: from Chemistry to Biology held at the Ciba Foundation, London, Jul. 3-5, 1990.
311   $a0-471-92958-1 
320   $aIncludes bibliographical references and indexes.
327   $aHOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
327   $aBinding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index
330   $aComposed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between prote
410  0$aCiba Foundation symposium ;$v158.
606   $aLigand binding (Biochemistry)$vCongresses
606   $aDrugs$xDesign$vCongresses
606   $aProtein engineering$vCongresses
606   $aProtein binding$vCongresses
615  0$aLigand binding (Biochemistry)
615  0$aDrugs$xDesign
615  0$aProtein engineering
615  0$aProtein binding
676   $a574.19/245
712 12$aSymposium on Host-Guest Molecular Interactions: from Chemistry to Biology$f(1990 :$eCiba Foundation)
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910877290203321
996   $aHost-guest molecular interactions$94191883
997   $aUNINA