LEADER 05611nam 2200601z 450 001 9910877247903321 005 20230830175403.0 010 $a9781119143499 010 $a1119143497 010 $a9781119143475 010 $a1119143470 010 $a9781119143505 010 $a1119143500 035 $a(CKB)4330000000008868 035 $a(Safari)9781119143468 035 $a(OCoLC)1031279370 035 $a(MiAaPQ)EBC5151462 035 $a(MiAaPQ)EBC7076134 035 $a(Au-PeEL)EBL7076134 035 $a(CaSebORM)9781119143468 035 $a(JP-MeL)3000132271 035 $a(NjHacI)994330000000008868 035 $a(OCoLC)on1031279370 035 $a(EXLCZ)994330000000008868 100 $a20230203d ||| || 135 $aurunu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMultivalency $econcepts, research & applications /$fedited by Jurriaan Huskens ... [et al.] 205 $a1st edition 210 $aHoboken, N.J.$cWiley$d2018 210 1$aHoboken, N.J. :$cWiley,$d2018. 215 $a1 online resource (1 volume) $cillustrations 300 $aOther editors: Leonard J. Prins, Rainer Haag, Bart Jan Ravoo 300 $aIncludes bibliographical references and index 311 08$a9781119143468 311 08$a1119143462 320 $aIncludes bibliographical references and index. 327 $aGeneral Introduction to Multivalent Interactions. Additivity of Energy Contributions in Multivalent Complexes / Hans-Jo?rg Schneider -- Models and Methods in Multivalent Systems / Jurriaan Huskens -- Design Principles for Super Selectivity using Multivalent Interactions / Tine Curk, Jure Dobnikar, Daan Frenkel -- Multivalency in Biosystems / Jens Dernedde -- Multivalent Systems in Chemistry. Multivalency in Cyclodextrin/Polymer Systems / Akihito Hashidzume, Akira Harada -- Cucurbit[n]uril-Mediated Multiple Interactions / Zehuan Huang, Xi Zhang -- Multivalency as a Design Criterion in Catalyst Development / Paolo Scrimin, Maria A Cardona, Carlos M Leo?n Prieto, Leonard J Prins -- Multivalent Molecular Recognition on the Surface of Bilayer Vesicles / Jens Voskuhl, Ulrike Kauscher, Bart Jan Ravoo -- Multivalent Systems in Biology. Blocking Pathogens by Multivalent Inhibitors / Sumati Bhatia, Benjamin Ziem, Rainer Haag -- Multivalent Protein Recognition Using Synthetic Receptors / Akash Gupta, Moumita Ray, Vincent M Rotello -- Multivalent Calixarenes for the Targeting of Biomacromolecules / Francesco Sansone, Alessandro Casnati -- Cucurbit[n]uril Assemblies for Biomolecular Applications / Emanuela Cavatorta, Luc Brunsveld, Jurriaan Huskens, Pascal Jonkheijm -- Multivalent Lectin-Glycan Interactions in the Immune System / Joa?o T Monteiro, Bernd Lepenies -- Blocking Disease Linked Lectins with Multivalent Carbohydrates / Marjon Stel, Roland J Pieters. 330 $aConnects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology. 606 $6880-03/$1$aValence (Theoretical chemistry) 606 $6880-04/$1$aMultivalent molecules 615 0$aValence (Theoretical chemistry) 615 0$aMultivalent molecules 676 $a541/.224 686 $a431.1$2njb/09 702 $aHuskens$b Jurriaan 801 1$bJP-MeL 906 $aBOOK 912 $a9910877247903321 996 $aMultivalency$94192995 997 $aUNINA