LEADER 05264nam 22006494a 450 001 9910877180703321 005 20200520144314.0 010 $a1-280-54158-X 010 $a9786610541584 010 $a0-470-02061-X 010 $a0-470-02062-8 035 $a(CKB)111090529068402 035 $a(EBL)189380 035 $a(OCoLC)475900792 035 $a(SSID)ssj0000144707 035 $a(PQKBManifestationID)11147582 035 $a(PQKBTitleCode)TC0000144707 035 $a(PQKBWorkID)10146749 035 $a(PQKB)10514591 035 $a(MiAaPQ)EBC189380 035 $a(EXLCZ)99111090529068402 100 $a20030724d2004 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 04$aThe eicosanoids /$fedited by Peter Curtis-Prior 210 $aChichester, England ;$aHoboken, NJ $cJohn Wiley & Sons$dc2004 215 $a1 online resource (656 p.) 225 1 $aFAO/Wiley Series on Food Agriculture 300 $aDescription based upon print version of record. 311 $a0-471-48984-0 320 $aIncludes bibliographical references and index. 327 $aThe Eicosanoids; Contents; List of Contributors; Preface; Preface from Prostaglandins; Acknowledgements; Foreword; SECTION ONE BIOSYNTHESIS AND METABOLISM; 1 Perspectives on the Biosynthesis and Metabolism of Eicosanoids; 2 Control of Eicosanoid Production by Cellular and Secreted Phospholipase A(2); 3 Mechanisms of PGH Synthase-1 (COX-1) Activity and Role of Radical States; 4 Regulation and Function of Prostaglandin Synthase-2/Cyclooxygenase II; 5 Mammalian Lipoxygenases; 6 Biosynthesis and Biological Effects of 5-oxo-ETE and Other Oxoeicosatetraenoic Acids; 7 Synthetic Eicosanoids 327 $aSECTION TWO ANALYTICAL METHODS8 Perspectives of Analytical Methods for Eicosanoids; 9 Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as Label; 10 Bioassay of Eicosanoids; 11 Gas Chromatography and Mass Spectrometry in Eicosanoid Analysis; 12 Time-resolved Fluoroimmunoassay in Eicosanoid Analysis; SECTION THREE BIOCHEMICAL AND MOLECULAR PHARMACOLOGY; 13 Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids; 14 Eicosanoid Antagonists 327 $a15 Biosynthesis and Degradation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors16 Inhibitors of Eicosanoids; 17 Biology and Chemistry of Products of the Isoprostane Pathway; 18 Insight into Prostanoid Functions: Lessons from Receptor-knockout Mice; SECTION FOUR IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC REGULATION; 19 Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation; 20 Prostaglandins and the Immune Response; 21 Leukotrienes in Aspirin-intolerant Asthma; 22 Essential Fatty Acids 327 $a23 Endothelial Secretory Function and Atherothrombosis24 Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and its Relevance to Diabetes Mellitus; 25 Prostaglandins, Leukotrienes and Bone; 26 Ageing and Prostaglandins; SECTION FIVE INFLAMMATION; 27 Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation; 28 Antiinflammatory Steroids; 29 Eicosanoids and Algesia in Inflammation; 30 Cyclooxygenase-2 in Cancer; 31 Cytokines and Eicosanoids in Arthritis; SECTION SIX CIRCULATORY SYSTEM 327 $a32 Perspectives and Clinical Significance of Eicosanoids in the Circulatory System33 Aspirin and Activated Platelets; 34 Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat; 35 Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels; SECTION SEVEN DIGESTIVE SYSTEM; 36 Perspectives and Clinical Significance of Eicosanoids in the Digestive System; 37 Eicosanoids and Liver Regeneration; 38 Eicosanoids and the Intestine; 39 Eicosanoids and Stomach Physiology; SECTION EIGHT NERVOUS SYSTEM 327 $a40 Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism in the Nervous System 330 $aThis comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins-NSAIDS (e.g. aspirin) are the biggest selling drugs of all 410 0$aFAO/Wiley Series on Food Agriculture 606 $aEicosanoids 606 $aEicosanoids$xPhysiological effect 606 $aEicosanoids$xTherapeutic use 615 0$aEicosanoids. 615 0$aEicosanoids$xPhysiological effect. 615 0$aEicosanoids$xTherapeutic use. 676 $a572/.57 701 $aCurtis-Prior$b P. B$0298830 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877180703321 996 $aThe eicosanoids$94204512 997 $aUNINA