LEADER 05150nam 2200601Ia 450 001 9910877171203321 005 20200520144314.0 010 $a1-280-72341-6 010 $a9786610723416 010 $a3-527-60820-6 010 $a3-527-60792-7 035 $a(CKB)1000000000377174 035 $a(EBL)482172 035 $a(OCoLC)85821186 035 $a(SSID)ssj0000300016 035 $a(PQKBManifestationID)11236508 035 $a(PQKBTitleCode)TC0000300016 035 $a(PQKBWorkID)10243624 035 $a(PQKB)11670181 035 $a(MiAaPQ)EBC482172 035 $a(EXLCZ)991000000000377174 100 $a20050527d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe interferons $echaracterization and application /$fedited by Anthony Meager 210 $aWeinheim $cWiley-VCH ;$aChichester $cJohn Wiley [distributor]$d2006 215 $a1 online resource (462 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31180-7 320 $aIncludes bibliographical references and index. 327 $aThe Interferons; Contents; Preface; List of Contributors; Color Plates; Section A Molecular Aspects, Introduction and Purification; 1 Type I Interferons: Genetics and Structure; 1.1 Introduction; 1.2 The Type I IFN Genetic Locus; 1.3 Type I IFN Genes; 1.3.1 IFN-?; 1.3.2 IFN-?; 1.3.3 IFN-?; 1.3.4 IFN-?; 1.3.5 IFN-?; 1.3.6 IFN-? (Limitin); 1.3.7 IFN-?; 1.3.8 IFN-?; 1.3.9 IFN-?; 1.4 Type I IFN Gene-regulatory Regions; 1.5 Evolution of the Type I IFNs; 1.5.1 Vertebrate IFN Genes; 1.5.2 The Expansion and Divergence of the IFN Genes; 1.6 Natural and Induced Mutations in IFN Genes 327 $a1.7 Secondary Structural Features of Type I IFNs1.7.1 Conserved Amino Acid Residues; 1.7.2 Post-translational Modifications of Type I IFNs; 1.7.3 Conserved Cysteine Residues and Disulfide Bond Formation; 1.8 The Structure of Type I IFNs; References; 2 Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways; 2.1 Introduction; 2.2 IFN-? Gene Transcription; 2.3 IRF Family Members; 2.4 Role of IRFs in Virus-mediated IFN Activation; 2.4.1 IRF-3; 2.4.2 IRF-5; 2.4.3 IRF-7; 2.5 IFN Signaling Pathways; 2.5.1 TLR-dependent Signaling to IFN Activation 327 $a2.5.1.1 TLR Overview2.5.1.2 TLR-3 Signaling; 2.5.1.3 TLR-4 Signaling; 2.5.1.4 TLR-7 Signaling; 2.5.1.5 TLR-9 Signaling; 2.5.2 TLR-independent Signaling; 2.5.2.1 Retinoic Acid Inducible Gene (RIG)-I Signaling; 2.5.2.2 Melanoma Differentiation-associated Gene-5 (mda-5); 2.6 Conclusions; References; 3 Interferon Proteins: Structure, Production and Purification; 3.1 Introduction; 3.2 The Structure of Type I IFNs; 3.3 Production and Purification of Type I IFNs; 3.3.1 Leukocyte-derived IFN - First Steps in Producing Commercial IFN; 3.3.2 Lymphoblastoid IFN - Towards more Reliable Supplies of IFN 327 $a3.3.3 Cloned Type I IFNs - An Inexhaustible Supply of Therapeutic Material3.4 Long-acting IFNs; 3.5 Summary; References; 4 Interferon-?: Gene and Protein Structure, Transcription Regulation, and Actions; 4.1 Introduction; 4.2 IFN-? Gene Structure and Regulation; 4.2.1 Transcriptional Regulation; 4.2.2 Epigenetic Regulation; 4.2.3 Post-transcriptional Regulation; 4.3 IFN-? Signal Transduction; 4.3.1 The JAK-STAT Signaling Pathway; 4.3.2 Activation of Alternate Signaling Pathways; 4.3.3 Regulation of IFN-? Signaling; 4.4 IFN-? in T(h) Cell Development 327 $a4.4.1 Signaling Pathways Involved in T Cell Development4.5 IFN-? and DCs; 4.5.1 IFN-? and T Cell-DC Crosstalk; 4.5.2 Signals through Toll-like Receptors (TLRs) Activate DCs and Influence IFN-? Expression; 4.6 IFN-? - Role in Tumor Development and Growth; 4.6.1 IFN-? in Tumor Growth and Survival; 4.6.2 Inhibition of Angiogenesis by IFN-?; 4.6.3 Role of IFN-? in Promoting Immune Responses against Tumors; 4.7 Summary; References; 5 Interferon and Related Receptors; 5.1 Introduction; 5.2 IFNs and IFN-like Molecules in Brief; 5.3 The Receptors; 5.3.1 Receptor Nomenclature 327 $a5.4 The Type I IFN Receptor 330 $aAt long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. For immunologists, cancer researchers, medic 606 $aInterferon 606 $aInterferon$xTesting 615 0$aInterferon. 615 0$aInterferon$xTesting. 676 $a616.0791 701 $aMeager$b Anthony$01760263 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877171203321 996 $aThe interferons$94199142 997 $aUNINA