LEADER 08578nam 22005533 450 001 9910877145303321 005 20231014060240.0 010 $a9781394175611 010 $a1394175612 010 $a9781394175635 010 $a1394175639 010 $a9781394175628 010 $a1394175620 035 $a(CKB)28352310900041 035 $a(MiAaPQ)EBC30783604 035 $a(Au-PeEL)EBL30783604 035 $a(Exl-AI)30783604 035 $a(EXLCZ)9928352310900041 100 $a20231014d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aIntegration of Biomaterials for Gene Therapy 205 $a1st ed. 210 1$aNewark :$cJohn Wiley & Sons, Incorporated,$d2023. 210 4$dİ2023. 215 $a1 online resource (435 pages) 311 08$a9781394174737 327 $aIntro -- Table of Contents -- Series Page -- Title Page -- Copyright Page -- Foreword -- Preface -- Acknowledgment -- 1 Biocompatible Hydrogels for Gene Therapy -- 1.1 Introduction -- 1.2 Hydrogels Classification -- 1.3 Fabrication of Hydrogels and Its Desirable Technical Features -- 1.4 Factors to be Tuned for Gene Encapsulation in Hydrogels -- 1.5 Recent Advances on Hydrogels for Gene Delivery -- 1.6 Conclusion -- References -- 2 Use of Polysaccharides -- 2.1 Introduction -- 2.2 Cross-Linking Techniques for Engineering Polysaccharides-Based Biomaterials -- 2.3 Approaches to Design Polysaccharide-Derived Biomaterials -- 2.4 Biomedical Applications of Polysaccharide-Derived Biomaterials -- 2.5 Advanced Biomaterials for Wound Dressings -- 2.6 Scaffolds for Tissue Engineering and Development of Bioinks for 3D Bioprinting -- 2.7 Recent Utilization of Polysaccharides -- 2.8 Toxicity Concerns of Polysaccharide-Derived Biomaterials -- 2.9 Preclinical and Clinical Studies on Gene Delivery Using Polysaccharide-Based Biomaterials -- 2.10 Challenges and Future Directions -- 2.11 Future Prospects -- 2.12 Conclusion -- References -- 3 Polysaccharide-Based Biomaterials for Gene Delivery -- 3.1 Background -- 3.2 Introduction -- 3.3 Gene Therapy -- 3.4 Gene Delivery Systems Based on Polysaccharides -- 3.5 Practical Application of Gene Delivery Systems -- 3.6 Polysaccharide-Based Nanoparticles -- 3.7 DNA Delivery -- 3.8 Conclusion -- References -- 4 Hydrogel-Based Gene Therapy -- 4.1 Introduction -- 4.2 Gene Therapy -- 4.3 In Vivo Gene Therapy Using Hydrogels -- 4.4 Encapsulating Cells in Hydrogels for Gene Therapy Delivery -- 4.5 Hydrogels for Integrative Tissue Engineering and Cell Delivery -- 4.6 Biocompatible Hydrogels for Transferring Cells -- 4.7 Using Hydrogels for Gene Therapy in Tissue Engineering-Based Drug. 327 $a4.8 Human Gene Therapy that Uses Hydrogel as an Alternative Method of Delivering Genetic Material to Patients -- 4.9 Recent Advancement in Biocompatible Hydrogel -- 4.10 Applications of Hydrogel -- 4.11 Current Hydrogels in Clinical Trials -- 4.12 Conclusions -- References -- 5 Progress and Prospects for Non-Viral Gene Therapy -- 5.1 Introduction -- 5.2 Definition -- 5.3 Technology Overview for Non-Viral Gene Delivery -- 5.4 Chemical Carriers for Gene Transfer: Establishing Effective In Vivo Gene Delivery -- 5.5 Types of Gene Delivery -- 5.6 Reduction of Immunological Responses Through Alteration of Delivery Method or DNA Structure -- 5.7 To Enable Long-Lasting Gene Expression, Self-Replicating, Tissue-Specific, and Integrating Plasmid Expression Systems are Designed -- 5.8 Hybrid Vector Systems to Improve Transfection and Lessen Cytotoxicity -- 5.9 Vehicle Material -- 5.10 Further Effects -- 5.11 Challenges and Prospects -- 5.12 Conclusion -- References -- 6 Nanoparticles for Tumor Gene Therapy -- 6.1 Introduction -- 6.2 Technologies for Gene Delivery -- 6.3 Cancer Treatment with Gene Therapy -- 6.4 Gene Therapy Using Nanotechnology -- 6.5 Challenges and Future Aspects -- References -- 7 Effective Gene Transfer with Non-Viral Vectors -- 7.1 Introduction -- 7.2 System Development for Delivering Genes -- 7.3 Methods for Non-Viral Vector for Delivery of Genes -- 7.4 Delivery System -- 7.5 Current Methods for Nonviral Gene Delivery: Benefits and Drawbacks -- 7.6 Current Barriers for Non-Viral Vectors -- 7.7 Possibilities for Enhancing the Non-Viral Vector Delivery System -- 7.8 Conclusion -- 7.9 Future Relevance -- References -- 8 Utilization of Chitosan for Gene Delivery -- 8.1 Introduction -- 8.2 Cationic Polymers-Based Gene Delivery Systems -- 8.3 Chitosan and Its Derivatives in Gene Delivery Systems -- 8.4 Chitosan as Chemotherapeutic Drugs. 327 $a8.5 Conclusion -- References -- 9 Nanoparticles as Gene Vectors in Tumor Therapy -- 9.1 Introduction -- 9.2 Polymer-Based Nanocarriers: Their Technology and Recent Advances -- 9.3 Conclusions -- References -- 10 Progress in Non-Viral Delivery of Nucleic Acid -- 10.1 Introduction -- 10.2 Physical Methods of Non-Viral Nucleic Acid Delivery System -- 10.3 Advantages and Disadvantages of Physical Transfection -- 10.4 Chemical Methods of Non-Viral Nucleic Acid Delivery System -- 10.5 Advantages and Disadvantages of Chemical Transfection -- 10.6 Cellular Barriers for Nucleic Acid Delivery Faced by Non-Viral Vectors -- 10.7 Challenges and Limitations of Non-Viral Nucleic Acid Delivery System -- 10.8 Conclusion -- References -- 11 The Junction of Biomaterials and Gene Therapy - Current Strategies and Future Directions -- 11.1 Introduction -- 11.2 Viral Gene Therapy -- 11.3 DNA Viral Vectors -- 11.4 Adeno-Associated Viral Vectors -- 11.5 Non-Viral Gene Therapy -- 11.6 Recent Advances in the Development of Gene Delivery Systems -- 11.7 Development of Gene Delivery Systems -- 11.8 Viral Vectors Based on DNA for Gene Delivery Systems -- 11.9 Viral Vectors Based on RNA for Gene Delivery Systems -- 11.10 Oncolytic Viral Vectors for Gene Delivery Systems -- 11.11 Practical Application of Gene Delivery Methods -- 11.12 Conclusion -- References -- 12 Utilization of Silk for Gene Delivery -- 12.1 Introduction -- 12.2 Dimensional Structure of Silk -- 12.3 Properties of Silk -- 12.4 Extraction of Fibroin from Silk Worm -- 12.5 Fabrication of Silk in Different Therapeutics Carriers -- 12.6 Utilization of Silk for Gene Therapy -- 12.7 Properties of Silk Fibroin as Biomaterial -- 12.8 Summary of Silk-Based Formulations for Gene Delivery [33] -- 12.9 Examples of Some Delivery Approaches which Utilizes Silk as a Biomaterial for Gene Delivery. 327 $a12.10 Some Highlights of Silk Fibroin -- 12.11 Conclusion -- References -- 13 Challenges and Emerging Problems in Nanomedicine Mediated Gene Therapy -- 13.1 Introduction -- 13.2 Why Nanomedicine Over Traditional Drugs? -- 13.3 Nanomedicine for Gene Therapy -- 13.4 Complications in Nanomedicine-Mediated Gene Therapy -- 13.5 Challenges in the Clinical Translation of Nanomedicines -- 13.6 Conclusion -- References -- 14 Biomaterials-Based Vaccination in Cancer Therapy -- 14.1 Introduction -- 14.2 Tumor-Associated Antigens -- 14.3 Vaccine Delivery -- 14.4 Dendritic Cells -- 14.5 In Vitro Generation of Dendritic Cells -- 14.6 Usage of RNA -- 14.7 RNA-Pulsed DCs as Vaccines -- 14.8 RNA Vaccines -- 14.9 Optimization of Immunotherapy -- 14.10 Cancer Treatment Through RNA Interference -- 14.11 Conclusion -- References -- Index -- End User License Agreement. 330 $aThis book explores the integration of biomaterials in gene therapy, highlighting advancements in the field. It covers the design and application of hydrogels, nanoparticles, and other biomaterials for effective gene delivery. The book discusses various gene delivery systems, including non-viral methods, and addresses challenges such as biocompatibility and clinical translation. Intended for researchers and professionals in biomedical engineering and biotechnology, the book aims to provide insights into recent technological developments and future directions in gene therapy. It also examines the role of biomaterials in cancer therapy and other medical applications.$7Generated by AI. 606 $aGene therapy$7Generated by AI 606 $aBiomedical engineering$7Generated by AI 615 0$aGene therapy 615 0$aBiomedical engineering 700 $aMalviya$b Rishabha$01430067 701 $aSundram$b Sonali$01430068 701 $aJain$b Neelam$01751366 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910877145303321 996 $aIntegration of Biomaterials for Gene Therapy$94186294 997 $aUNINA