LEADER 03802nam 22006134a 450 001 9910876871303321 005 20200520144314.0 010 $a1-280-51891-X 010 $a9786610518913 010 $a0-470-02957-9 010 $a0-470-02956-0 035 $a(CKB)1000000000357348 035 $a(EBL)267158 035 $a(SSID)ssj0000148787 035 $a(PQKBManifestationID)11147020 035 $a(PQKBTitleCode)TC0000148787 035 $a(PQKBWorkID)10225175 035 $a(PQKB)11243726 035 $a(MiAaPQ)EBC267158 035 $a(OCoLC)85784250 035 $a(EXLCZ)991000000000357348 100 $a20070403d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aEpithelial anion transport in health and disease $ethe role of the SLC26 transporters family 210 $aChichester, U.K. $cJohn Wiley & Sons$d2006 215 $a1 online resource (285 p.) 225 1 $aNovartis Foundation Symposium ;$v273 300 $aDescription based upon print version of record. 311 $a0-470-01624-8 320 $aIncludes bibliographical references and index. 327 $aCover; Contents; Chair's introduction; Overview of the SLC26 family and associated diseases; Discussion; Individual characteristics of members of the SLC26 family in vertebrates and their homologues in insects; Discussion; Sulfate transport by SLC26 transporters; Discussion; Sugar transport by members of the SLC26 superfamily; Discussion; SLC26A3 and congenital chloride diarrhoea; Discussion; Expression, regulation and the role of SLC26 C1/HCO exchangers in kidney and gastrointestinal tract; Discussion 327 $aAnion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptidesDiscussion; Physiology of electrogenic SLC26 paralogues; Discussion; Role of SLC26-mediated C1/base exchange in proximal tubule NaCl transport; Discussion; SLC26 transporters and the inhibitory control of pancreatic ductal bicarbonate secretion; Discussion; Regulatory interaction between CFTR and the SLC26 transporters; Discussion; Insights from a transgenic mouse model on the role of SLC26A2 in health and disease; Discussion 327 $aNew insights into the role of pendrin (SLC26A4) in inner ear fluid homeostasisDiscussion; The renal physiology of pendrin (SLC26A4) and its role in hypertension; Discussion; Interaction of prestin (SLC26A5) with monovalent intracellular anions; Discussion; Final discussion; Index of contributors; Subject index 330 $aCl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on ot 410 0$aNovartis Foundation symposium ;$v273. 606 $aEpithelial cells$vCongresses 606 $aCarrier proteins$vCongresses 606 $aIon channels$vCongresses 615 0$aEpithelial cells 615 0$aCarrier proteins 615 0$aIon channels 676 $a572/.696 712 12$aSymposium on Epithelial Anion Transport in Health and Disease: the Role of the SLC26 Transporters Family 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910876871303321 996 $aEpithelial anion transport in health and disease$94202433 997 $aUNINA