LEADER 05422nam 2200673 a 450 001 9910876776403321 005 20200520144314.0 010 $a1-282-13816-2 010 $a9786612138164 010 $a0-470-74344-1 010 $a0-470-74343-3 035 $a(CKB)1000000000719687 035 $a(EBL)427929 035 $a(OCoLC)476271568 035 $a(SSID)ssj0000354666 035 $a(PQKBManifestationID)11925306 035 $a(PQKBTitleCode)TC0000354666 035 $a(PQKBWorkID)10315040 035 $a(PQKB)11400184 035 $a(MiAaPQ)EBC427929 035 $a(EXLCZ)991000000000719687 100 $a20081031d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPreparation of compounds labeled with tritium and carbon-14 /$fRolf Voges, J. Richard Heys, Thomas Moenius 210 $aChichester, United Kingdom $cWiley$d2009 215 $a1 online resource (684 p.) 300 $aDescription based upon print version of record. 311 $a0-470-51607-0 320 $aIncludes bibliographical references and index. 327 $aPreparation of Compounds Labeled with Tritium and Carbon-14; Contents; Preface; Glossary; Author Biographies; 1 Introduction; 1.1 Physical Properties of Tritium and Carbon-14; 1.2 Purification; 1.3 Analysis; 1.3.1 Chemical Identity; 1.3.2 Chemical (and Enantiomeric) Purity; 1.3.3 Radiochemical (and Radionuclidic) Purity; 1.3.4 Specific Activity; 1.3.5 Position of Label; 1.4 Stability and Storage of Compounds Labeled with Tritium or Carbon-14; 1.5 Specialist Techniques and Equipment; References; 2 Strategies for Target Preparation; 2.1 Formulating Target Specifications 327 $a2.2 Planning Radiotracer Preparations2.2.1 The Construction Strategy; 2.2.2 Reconstitution Strategies; 2.2.3 The Derivatization Strategy; 2.2.4 Selection of an Appropriate Strategy; 2.2.5 Case Studies of Strategy Development; References; 3 Preparation of Tritium-Labeled Compounds by Isotope Exchange Reactions; 3.1 Homogeneous Acid- or Base-Catalyzed Exchange; 3.1.1 Exchange without Added Acid or Base; 3.1.2 Exchange under Acidic Conditions; 3.1.3 Exchange under Basic Conditions; 3.2 Heterogeneous Catalysis with Tritium in Solvent; 3.2.1 Metals; 3.2.2 Other Catalysts 327 $a3.3 Heterogeneous Catalysis in Solution with Tritium Gas3.3.1 Metal Catalysts with Nonreducible Substrates in Aqueous Solution; 3.3.2 Metal Catalysts with Nonreducible Substrates in Organic Solvents; 3.3.3 Other Catalysts; 3.3.4 Metal Catalysts with Reducible Substrates; 3.4 Homogeneous Catalysis in Solution with Tritiated Water; 3.4.1 Exchange Catalyzed by Metal Salts; 3.4.2 Exchange Catalyzed by Organoruthenium Complexes; 3.4.3 Exchange Catalyzed by Iridium Dionates; 3.4.4 Exchange Catalyzed by Iridium Cyclopentadienides; 3.5 Homogeneous Catalysis with Tritium Gas; 3.5.1 Iridium Phosphines 327 $a3.5.2 Iridium Dionate Complexes3.5.3 Iridium Cyclopentadienide Complexes; 3.6 Solvent-Free Catalytic Exchange; 3.6.1 High-Temperature Solid-State Catalytic Isotope Exchange; 3.6.2 Thermal Tritium Atom Bombardment; 3.6.3 Other Radiation-Induced Labeling Methods; References; 4 Preparation of Tritium-Labeled Compounds by Chemical Synthesis; 4.1 Catalytic Tritiations; 4.1.1 Tritiation of Carbon-Carbon Multiple Bonds; 4.1.2 Tritiation of Carbon-Heteroatom Multiple Bonds; 4.1.3 Homogeneously Catalyzed Reactions; 4.2 Catalytic Tritiolyses; 4.2.1 Tritiodehalogenations 327 $a4.2.2 Tritiolyses of Benzylic N- and O-Functions4.2.3 Tritiodesulfurizations; 4.3 Tritide Reductions; 4.3.1 Sodium Borotritide (NaB3H4 ); 4.3.2 Sodium Cyanoborotritide (NaB3H3CN); 4.3.3 Sodium/Tetramethylammonium Triacetoxyborotritide [Na/NMe4B3H(OAc)3]; 4.3.4 Lithium Tritide (Li3H); 4.3.5 Lithium Borotritide (LiB3H4); 4.3.6 Lithium Triethylborotritide (LiEt3B3H, Li-Super-Tritide); 4.3.7 Lithium Tri-sec-Butylborotritide [Li(sec-Bu3)B3H, Li T-Selectride]; 4.3.8 Lithium [3H2]Boratabicyclo[3.3.1]nonane; 4.3.9 Tritiated Borane (THF-Complex) (B2 3H6; B3H3 .THF); 4.3.10 Tritiated Alkylboranes 327 $a4.3.11 Lithium Aluminum Tritide (LiAl3H4) 330 $aCompounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustratin 606 $aOrganic compounds$xSynthesis 606 $aRadiolabeling 606 $aTritium 606 $aCarbon$xIsotopes 615 0$aOrganic compounds$xSynthesis. 615 0$aRadiolabeling. 615 0$aTritium. 615 0$aCarbon$xIsotopes. 676 $a572/.36 700 $aVoges$b R$g(Rolf)$01752998 701 $aHeys$b J. R$g(J. Richard)$01752999 701 $aMoenius$b Thomas$01753000 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910876776403321 996 $aPreparation of compounds labeled with tritium and carbon-14$94188517 997 $aUNINA