LEADER 04384nam 2200625Ia 450 001 9910876751703321 005 20200520144314.0 010 $a1-282-34264-9 010 $a9786612342646 010 $a0-470-69963-9 010 $a0-470-69964-7 035 $a(CKB)1000000000579165 035 $a(EBL)406523 035 $a(OCoLC)476226042 035 $a(SSID)ssj0000260716 035 $a(PQKBManifestationID)11208917 035 $a(PQKBTitleCode)TC0000260716 035 $a(PQKBWorkID)10224612 035 $a(PQKB)11273469 035 $a(MiAaPQ)EBC406523 035 $a(PPN)194571602 035 $a(EXLCZ)991000000000579165 100 $a20080611d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aToxicogenomics $ea powerful tool for toxicity assessment /$feditor, Saura C. Sahu 210 $aChichester, UK $cJohn Wiley & Sons$d2008 215 $a1 online resource (439 p.) 300 $aDescription based upon print version of record. 311 $a0-470-51823-5 320 $aIncludes bibliographical references and index. 327 $aToxicogenomics; Contents; Preface; List of Contributors; Acknowledgments; SECTION 1 DESIGN, ANALYSIS AND INTERPRETATION OF TOXICOGENOMICS; 1 Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments; 2 A New Approach to Analysis and Interpretation of Toxicogenomic Gene Expression Data and its Importance in Examining Biological Responses to Low, Environmentally Relevant Doses of Toxicants; 3 Principles of Data Mining in Toxicogenomics; 4 Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research 327 $a5 Sources of Variability in Toxicogenomic Assays6 Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug-Induced Toxicity; SECTION 2 APPLICATIONS OF TOXICOGENOMICS; 7 Toxicogenomics as a Tool to Assess Immunotoxicity; 8 Toxicogenomics and Ecotoxicogenomics: Studying Chemical Effects and Basic Biology in Vertebrates and Invertebrates; 9 Gene Expression Profiling of Transplacental Arsenic Carcinogenesis in Mice; 10 Characterization of Estrogen-active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro 327 $a11 Escherichia coli Stress Response as a Tool for Detection of Toxicity12 Toxicogenomics In Vitro: A Powerful Tool for Screening Hepatotoxic Potential of Food-related Products; 13 Toxicogenomics Approach to Drug-induced Phospholipidosis; 14 Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity; 15 Nutrigenomics: The Application of Genomics Signatures in Nutrition-related Research; 16 Application of Toxicogenomics in Drug Discovery; SECTION 3 TOXICOGENOMICS AND RISK ASSESSMENT; 17 Natural Products from Medicinal Plants and Risk Assessment 327 $a18 The Development of a Metabonomic-based Drug Safety Testing Paradigm19 Potential Uses of Toxicogenomic Biomarkers in Occupational Health and Risk Assessment; SECTION 4 TOXICOGENOMICS FOR REGULATORY USE; 20 Toxicogenomics: A Regulatory Perspective; 21 Toxicogenomics for Regulatory Use: The View from the Bench; 22 Perspectives on Toxicogenomics Activities at the US Environmental Protection Agency; Index; Color Plate 330 $aToxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to in 606 $aGenetic toxicology 606 $aGenomics 606 $aProteomics 615 0$aGenetic toxicology. 615 0$aGenomics. 615 0$aProteomics. 676 $a616.042 676 $a616/.042 701 $aSahu$b Saura C$0860594 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910876751703321 996 $aToxicogenomics$94201037 997 $aUNINA