LEADER 03895nam 2200661Ia 450 001 9910876751503321 005 20200520144314.0 010 $a1-280-27080-2 010 $a9780470857900 010 $a9786610270804 010 $a0-470-66805-9 010 $a0-470-85790-0 010 $a0-470-85789-7 035 $a(CKB)111087027094326 035 $a(EBL)152692 035 $a(SSID)ssj0000177810 035 $a(PQKBManifestationID)11182258 035 $a(PQKBTitleCode)TC0000177810 035 $a(PQKBWorkID)10218802 035 $a(PQKB)10258081 035 $a(MiAaPQ)EBC152692 035 $a(OCoLC)53847725 035 $a(EXLCZ)99111087027094326 100 $a20020919d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$a'In silico' simulation of biological processes /$f[editors, Gregory Bock and Jamie A. Goode] 210 $aChichester, West Sussex, UK ;$aHoboken, NJ $cJohn Wiley$d2002 215 $a1 online resource (272 p.) 225 1 $aNovartis Foundation symposium ;$v247 300 $a"Symposium on 'In silico' simulation of biological processes, held at the Novartis Foundation, London, 27-29 November 2001"--Contents p. 311 $a0-470-84480-9 320 $aIncludes bibliographical references and indexes. 327 $a'IN SILICO' SIMULATION OF BIOLOGICAL PROCESSES; Contents; Participants; Chair's introduction; Integrative biological modelling in silico; Discussion; Advances in computing, and their impact on scientific computing; Discussion; From physics to phenomenology. Levels of description and levels of selection; Making sense of complex phenomena in biology; Discussion; On ontologies for biologists: the Gene Ontology-untangling the web; Discussion; General discussion I; Model validation; The KEGG database; Discussion; Bioinformatics of cellular signalling; Discussion; General discussion II 327 $aStandards of communicationSemantics and intercommunicability; Imaging-based integrative models of the heart: closing the loop between experiment and simulation; Discussion; General discussion III; Modelling Ca(2+) signalling; The Virtual Cell project; Discussion; Modelling the bacterial chemotaxis receptor complex; The heart cell in silico: successes, failures and prospects; Discussion; Discussion; General discussion IV; The IUPS Physiome Project; Discussion; Using in silico biology to facilitate drug development; Discussion; Final discussion; Is there a theoretical biology? 327 $aIndex of contributorsSubject index 330 $aOver recent decades vast amounts of biological data have been accumulated. However, it is becoming increasingly difficult to apply traditional theoretical methods to the formulation of coherent pictures of cell and organ function because it is no longer possible for a human theorist to integrate all of the available information. Instead, computer technologies must now be used to perform this integration. This book brings together contributions from many different fields to summarize the current status of computer-assisted modelling of biological processes. The initial chapters deal with fund 410 0$aNovartis Foundation symposium ;$v247. 606 $aBiology$xComputer simulation$vCongresses 606 $aBioinformatics$vCongresses 615 0$aBiology$xComputer simulation 615 0$aBioinformatics 676 $a570/.1/13 676 $a660.6 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 712 12$aSymposium on 'In Silico' Simulation of Biological Processes$f(2001 :$eLondon, England) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910876751503321 996 $aIn silico' simulation of biological processes$94201036 997 $aUNINA