LEADER 05240nam 22006374a 450 001 9910876627803321 005 20200520144314.0 010 $a1-280-52038-8 010 $a9786610520381 010 $a3-527-60529-0 010 $a3-527-60145-7 035 $a(CKB)1000000000019317 035 $a(EBL)481642 035 $a(OCoLC)174056223 035 $a(SSID)ssj0000104500 035 $a(PQKBManifestationID)11138246 035 $a(PQKBTitleCode)TC0000104500 035 $a(PQKBWorkID)10079755 035 $a(PQKB)11381024 035 $a(MiAaPQ)EBC481642 035 $a(EXLCZ)991000000000019317 100 $a20030331d2003 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aApoptosis and autoimmunity /$fedited by M. Hermann and J.R. Kalden 210 $aWeinheim $cWiley-VCH$dc2003 215 $a1 online resource (405 p.) 300 $a"From mechanism to treatments"--Cover. 311 $a3-527-30442-8 320 $aIncludes bibliographical references and index. 327 $aApoptosis and Autoimmunity; Preface; Contents; List of Contributors; Part 1 General Features of Apoptosis; 1 Apoptosis and Autoimmunity; 1.1 Introduction; 1.2 Autoimmune Diseases Associated with Targeted Cell Destruction; 1.2.1 What is the Mode of Cell Death?; 1.2.2 What Cells and What Effector Pathways are Responsible for Cell Death?; 1.3 Autoimmune Diseases Associated with Enhanced Cell Growth and Survival; 1.4 Autoimmune Diseases Associated with Abnormal Processing of Dying Cells; 1.5 Conclusions; 1.6 References; 2 Caspase Knockouts: Matters of Life and Death 327 $a2.1 Death, Development and Immune Function2.2 Apoptotic Pathways: from Nematode to Mammals; 2.3 Triggering a Killer: General Aspects of Caspase Activation; 2.4 Caspase-1 and -11: More than Mediators of Inflammatory Cytokines?; 2.5 Caspase-8 and the FAS Signaling Pathway; 2.6 Caspase-3: The Chief Executioner?; 2.7 Caspase-9: Mitochondrial Activation and the Apoptosome; 2.8 Caspase-2: A Duality of Function; 2.9 Caspase-12: Responding to Stress; 2.10 Compensatory Caspase Activation: A Caveat to Knockout Analysis; 2.11 Caspases: More than Simple Killers; 2.12 Concluding Remarks; 2.13 References 327 $aPart 2 Clearance of Apoptotic Cells3 Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells; 3.1 Introduction; 3.2 Anti-inflammatory Effects of Apoptotic Cells on Monocytes/Macrophages; 3.3 The Role of Anti-inflammatory Cytokines for the Inhibition of Pro-inflammatory Cytokine Production; 3.4 Monocyte/Macrophage Receptors receiving the Anti-inflammatory Signal from Apoptotic Cells; 3.5 Intracellular Signaling Events Causing the Anti-inflammatory State in Macrophages; 3.6 Apoptotic Cells Impair MHC Class II Surface Expression on Monocytes 327 $a3.7 Influence of Apoptotic Cells on DC Function in Allogeneic MLR3.8 The Presence of Apoptotic Cells can Shift the T(h) Cell Response towards T(h)2; 3.9 Apoptotic Cells Suppress Delayed-type Hypersensitivity (DTH) In Vivo; 3.10 Necrosis and Inflammation; 3.11 Implications of the Anti-inflammatory and Immunodulatory Effects of Apoptotic Cells for Health and Disease; 3.11.1 Apoptosis and Pregnancy; 3.11.2 Apoptosis and Irradiation; 3.11.3 Apoptosis and Cancer; 3.11.4 Apoptosis and Infections; 3.11.5 Apoptosis and Blood Transfusions; 3.12 References; 4 Complement and Apoptosis; 4.1 Introduction 327 $a4.2 Programmed Cell Death (PCD)4.3 Complement; 4.4 Complement and Apoptosis; 4.4.1 Role of Complement in the Execution Phase; 4.4.2 Complement Activation by Apoptotic Cells; 4.5 Apoptosis, Complement and Autoimmunity; 4.6 References; 5 Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: The Role of Pentraxins, Collectins and Autoantibodies; 5.1 Introduction; 5.2 Soluble Factors Involved in Apoptotic Cell Recognition and Internalization; 5.2.1 Corpse Clearance at Rest: Collectins; 5.2.2 Corpse Clearance at Rest: Cationic Factors and Other PS-binding Moieties 327 $a5.2.3 Corpse Clearance during Acute Inflammation: Pentraxins 330 $aThis is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies. 606 $aApoptosis 606 $aAutoimmunity 606 $aAutoimmune diseases 615 0$aApoptosis. 615 0$aAutoimmunity. 615 0$aAutoimmune diseases. 676 $a571.9/73 701 $aHerrmann$b M$g(Martin),$cDr.$01752729 701 $aKalden$b J. R$g(Joachim Robert)$01752730 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910876627803321 996 $aApoptosis and autoimmunity$94188114 997 $aUNINA