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100   $a19871104d1988      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aNovel infectious agents and the central nervous system
210   $aChichester ;$aNew York $cWiley$d1988
215   $a1 online resource (290 p.)
225 1 $aCiba Foundation symposium ;$v135
300   $a"A Wiley-Interscience publication."
300   $aPapers and discussions from the Symposium on Novel Infectious Agents and the Central Nervous System, held at the Ciba Foundation, London, June 30-July 2, 1987.
311   $a0-471-91512-2 
320   $aIncludes bibliographies and indexes.
327   $aNOVEL INFECTIOUS AGENTSANDTHE CENTRAL NERVOUS SYSTEM; Contents; Participants; Introduction; The clinical neurology and epidemiology of Creutzfeldt-Jakob disease, with special reference to iatrogenic cases; Neuropathology of unconventional virus infections: molecu lar pathology of spongiform change and amyloid plaque deposit ion; Pathogenesis of experimental scrapie; Genetic aspects of unconventional virus infections: the basis of the virino hypothesis; Genetic control of prion incubation period in mice; Developmental regulation of prion protein mRNA in brain
327   $aPotential involvement of retroviral elements in human dementiasScrapie: a virus-induced amyloidosis of the brain; Scrapie-associated fibrils, PrP protein and the Sinc gene; A modified host protein model of scrapie; Properties of scrapie prion proteins in liposomes and amyloid rods; In vitro expression of cloned PrP cDNA derived from scrapie-infected mouse brain: lack of transmission of scrapie infectivity; Search for a scrapie-specific nucleic acid: a progress report; Pathogenesis of amyloid formation in Alzheimer's disease, Down's syndrome and scrapie
327   $aNovel mechanisms of degeneration of the central newous system - prion structure and biologyFinal general discussion; Summary; Index of contributors; Subject index
330   $aThe term ``unconventional virus'' refers to virus-like agents that differ from conventional viruses in significant respects--resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained 
410  0$aCiba Foundation symposium ;$v135.
606   $aCentral nervous system$xDiseases$xEtiology$vCongresses
606   $aScrapie$vCongresses
606   $aPrions$vCongresses
615  0$aCentral nervous system$xDiseases$xEtiology
615  0$aScrapie
615  0$aPrions
676   $a616.8
676   $a616.83
712 02$aCiba Foundation.
712 12$aSymposium on Novel Infectious Agents and the Central Nervous System$f(1987 :$eCiba Foundation)
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910876518203321
996   $aNovel infectious agents and the central nervous system$9898546
997   $aUNINA