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100   $a19970923d1997      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aTelomeres and telomerase /$f[editors, Derek J. Chadwick and Gail Cardew]
210   $aChichester, England ;$aNew York $cJohn Wiley & Sons$d1997
215   $a1 online resource (252 p.)
225 1 $aCiba Foundation symposium ;$v211
300   $aSymposium held at Ciba Foundation, Feb. 25-27, 1997.
311   $a0-471-97278-9 
320   $aIncludes bibliographical references and indexes.
327   $aTELOMERES AND TELOMERASE; Contents; Participants; Introduction; The telomere and telomerase: how do they interact?; Telomerase and the chromosome end replication problem; General discussion I; The role of the EST genes in yeast telomere replication; Drosophila telornere elongation; General discussion I1; Raplp and telomere length regulation in yeast; Chromatin and ageing in yeast and in mammals; The limited reproductive life span of normal human cells in culture; Human ageing and telorneres; General discussion I11; Telomerase assays in the diagnosis and prognosis of cancer
327   $aMouse models for the study of telomeraseGenetic control of telomerase and replicative senescence in human and rodent cells; Repair and processing events at DNA ends; Telomeres in the haemopoietic system; Final general discussion; Summary; Index of contributors; Subject index
330   $aTelomeres and Telomerase Chairman: Sydney Brenner 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5??? to 3??? direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short s
410  0$aCiba Foundation symposium ;$v211.
606   $aTelomere$vCongresses
606   $aTelomerase$vCongresses
615  0$aTelomere
615  0$aTelomerase
676   $a572.8
676   $a572.87
701   $aChadwick$b Derek$091632
701   $aCardew$b Gail$0857118
712 02$aCiba Foundation.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910876516603321
996   $aTelomeres and telomerase$94190263
997   $aUNINA