LEADER 04126nam 22005895 450 001 9910874676403321 005 20240720122226.0 010 $a9783031551635$b(electronic bk.) 010 $z9783031551628 024 7 $a10.1007/978-3-031-55163-5 035 $a(MiAaPQ)EBC31538227 035 $a(Au-PeEL)EBL31538227 035 $a(CKB)33101362300041 035 $a(DE-He213)978-3-031-55163-5 035 $a(EXLCZ)9933101362300041 100 $a20240719d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Mechanisms Determining Mammalian Oocyte Quality $eOocyte Developmental Competence, Aneuploidy, and Clinical Relevance /$fedited by Ahmed Z. Balboula 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (135 pages) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v238 311 08$aPrint version: Balboula, Ahmed Z. Molecular Mechanisms Determining Mammalian Oocyte Quality Cham : Springer International Publishing AG,c2024 9783031551628 327 $aChapter 1. Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality -- Chapter 2. Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence -- Chapter 3. Mechanisms of DNA Damage Response in Mammalian Oocytes -- Chapter 4. How do Environmental Toxicants Affect Oocyte Maturation via Oxidative Stress? -- Chapter 5. Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy -- Chapter 6. Telomere Elongation during Pre-implantation Embryo Development. 330 $aAs the age of childbearing increases, reduced female gamete (egg) quality has emerged as the primaery cause of infertility in women. This book addresses molecular mechanisms that regulate oocyte quality as well as intrinsic and extrinsic factors that compromise these mechanisms. Eggs are produced through a unique cell division called meiosis. Oocyte meiosis is initiated early in fetal life. Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I. Following meiotic resumption and during oocyte maturation, tight regulation of nuclear and DNA-related mechanisms ensures proper homologous chromosome segregation prior to another arrest at metaphase II. Any errors prior to completion of meiosis I can lead to chromosome segregation errors and aneuploidy, the most common genetic cause of miscarriage and congenital disorders such as Down syndrome. In addition to nuclear maturation, several cytoplasmic processes are orchestrated to support cell division and to generate developmentally competent eggs capable of supporting fertilization and early embryonic development. The interaction between these nuclear and cytoplasmic processes is critical for producing good-quality oocytes. This volume in the Advances in Anatomy, Embryology and Cell Biology book series presents current reviews by leading experts. It offers valuable insights for researchers, physicians and Ph.D. students interested in reproductive biology, particularly oocyte quality and meiosis. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v238 606 $aReproduction 606 $aPhysiology 606 $aCytology 606 $aReproductive health 606 $aReproductive Physiology 606 $aCell Biology 606 $aReproductive Medicine 615 0$aReproduction. 615 0$aPhysiology. 615 0$aCytology. 615 0$aReproductive health. 615 14$aReproductive Physiology. 615 24$aCell Biology. 615 24$aReproductive Medicine. 676 $a599 700 $aBalboula$b Ahmed Z$01749220 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910874676403321 996 $aMolecular Mechanisms Determining Mammalian Oocyte Quality$94183254 997 $aUNINA