LEADER 05649nam 22006855 450 001 9910874672003321 005 20250808093145.0 010 $a3-031-62731-8 024 7 $a10.1007/978-3-031-62731-6 035 $a(MiAaPQ)EBC31534312 035 $a(Au-PeEL)EBL31534312 035 $a(CKB)33030844100041 035 $a(DE-He213)978-3-031-62731-6 035 $a(OCoLC)1449547744 035 $a(EXLCZ)9933030844100041 100 $a20240717d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTranscription factors in blood cell development /$fedited by Tilman Borggrefe, Benedetto Daniele Giaimo 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (457 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1459 311 08$a3-031-62730-X 327 $aPart 1 ? Stem/Progenitor Cells -- Chapter 1. MYB - A Key Transcription Factor in the Hematopoietic System Subject to many Levels of Control - Roza Berhanu Lemma, Bettina Maria Fuglerud, Jon Frampton & Odd Stokke Gabrielsen -- Part 2 ? T-Cells -- Chapter 2. Ikaros Family Transcription Factors in Lymphocyte Differentiation and Function - Philippe Kastner & Susan Chan -- Chapter 3. The Role of the Transcriptional Co-Activator BOB.1/OBF.1 in Adaptive Immunity - Annika C. Betzler & Cornelia Brunner -- Chapter 4. Key Functions of the Transcription Factor BCL6 during T-Cell Differentiation - Chara Konstantakopoulou & Mihalis Verykokakis -- Part 3 ? B-Cells -- Chapter 5. The Function of E2A in B-Cell Development - Masaki Miyazaki & Kazuko Miyazaki -- Chapter 6. Hypoxia and the Hypoxia-Inducible Factors in Lymphocyte Differentiation and Function - Mark Boothby & Sung Hoon Cho -- Chapter 7. Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease - Mikael Sigvardsson -- Part 4 ? Myeloid Cells -- Chapter 8. Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function - Marc Pfefferlé & Florence Vallelian -- Part 5 ? Erythroid Cells -- Chapter 9. Trancriptional Repressor BCL11A In Erythroid Cells - Ge Zheng & Stuart H. Orkin -- Chapter 10. Erythroid Krüppel-like Factor / KLF1: a Surprisingly Versatile Regulator of Erythroid Differentiation - James J Bieker & Sjaak Philipsen -- Chapter 11. Transcription Factor TAL1 in Erythropoiesis - Johannes Fechner & Jörn Lausen -- Part 6 ? Megakaryocytes -- Chapter 12. GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development - Kaoru Takasaki & Stella T. Chou -- Part 7 ? Leukemia/Lymphoma -- Chapter 13. The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and other Hematopoietic Cancers - Alexander C. Monovich, Aishwarya Gurumurthy & Russell J.H. Ryan -- Chapter 14. Function of PML-RARA in Acute Promyelocytic Leukemia - Ugo Testa & Elvira Pelosi -- Cha[ter 15. MYB as a Critical Transcription Factor and Potential Therapeutic Target in AML - Mary Louise Clarke, Odd Stokke Gabrielsen & Jon Frampton -- Chapter 16. ETS1 Function in Leukemia and Lymphoma - Rebecca A. Luchtel -- Chapter 17. The Molecular and Biological Function of MEF2D in Leukemia - Pengcheng Zhang & Rui Lu -- Chapter 18. HOXA9 Regulome and Pharmacological Interventions in Leukemia - Sajesan Aryal & Rui Lu. 330 $aThis book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1459 606 $aGenetic transcription 606 $aCytology 606 $aPost-translational modification 606 $aHematopoietic system 606 $aDevelopmental biology 606 $aGene Transcription 606 $aCell Biology 606 $aPost-translational Modifications 606 $aHaematopoietic System 606 $aDevelopmental Biology and Stem Cells 615 0$aGenetic transcription. 615 0$aCytology. 615 0$aPost-translational modification. 615 0$aHematopoietic system. 615 0$aDevelopmental biology. 615 14$aGene Transcription. 615 24$aCell Biology. 615 24$aPost-translational Modifications. 615 24$aHaematopoietic System. 615 24$aDevelopmental Biology and Stem Cells. 676 $a572.8845 700 $aBorggrefe$b Tilman$01749468 701 $aGiaimo$b Benedetto Daniele$01749469 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910874672003321 996 $aTranscription Factors in Blood Cell Development$94183696 997 $aUNINA