LEADER 04118nam 22007215 450 001 9910874670703321 005 20251107172536.0 010 $a9783031563638 010 $a3031563638 024 7 $a10.1007/978-3-031-56363-8 035 $a(MiAaPQ)EBC31531957 035 $a(Au-PeEL)EBL31531957 035 $a(CKB)33063555500041 035 $a(MiAaPQ)EBC31806637 035 $a(Au-PeEL)EBL31806637 035 $a(OCoLC)1450308151 035 $a(DE-He213)978-3-031-56363-8 035 $a(EXLCZ)9933063555500041 100 $a20240717d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHandbook of the Extracellular Matrix $eBiologically-Derived Materials /$fedited by F. Raquel Maia, J. Miguel Oliveira, Rui L. Reis 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (1322 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$a9783031563621 311 08$a303156362X 327 $aExtracellular matrix composition -- The role of fibrous networks on the extracellular matrix mechanical properties -- Extracellular matrix structural features -- Extracellular matrix bioactive molecules and cell behavior modeling -- Mechanotransduction role at gene expression levels -- Extracellular matrix structure regulates local cell-matrix biomechanics -- Extracellular matrix isolation: sources and methods -- Extracellular matrix and its involvement in tissue generation -- Strategies for mimicking extracellular matrix -- Extracellular matrix remodeling on cancer progression. 330 $aThis book comprises of 6 sections covering the fundamentals of the extracellular matrix, as well as the development and challenges of using biologically-derived materials, and its advanced biomedical applications. The first section is dedicated to the extracellular matrix, while the other 5 sections are each dedicated to a particular type of material. This book reports the fundamentals of the extracellular matrix and its impact in the development of innovative materials; provides an overview of the advanced methodologies to develop biologically-derived materials; and describes the challenges of the synthesis and processing of the different materials. Furthermore, it presents the biological activities, structural and physicochemical properties of such materials, and the modification methods pursued to improve their inherent properties. The wide range of advanced applications are covered as well, including the combination with emerging technologies, underlyingtissue-engineered scaffolding, drug delivery systems, 3D in vitro tissue and cancer models, 3D bioprinted models, bioinks, and more. This reference work serves as a core reference for multidisciplinary students (undergraduates and Ph.D. students) and a wide range of established researchers and professionals working in the medical field, e.g., orthopaedics, radiology, dentistry, and cancer. 410 0$aBiomedical and Life Sciences Series 606 $aBiomaterials 606 $aCells 606 $aBiomedical engineering 606 $aProteins 606 $aBiomaterials-Cells 606 $aBiomedical Engineering and Bioengineering 606 $aBiomaterials-Proteins 606 $aBiomaterials 606 $aBiomedical Materials 615 0$aBiomaterials. 615 0$aCells. 615 0$aBiomedical engineering. 615 0$aProteins. 615 14$aBiomaterials-Cells. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aBiomaterials-Proteins. 615 24$aBiomaterials. 615 24$aBiomedical Materials. 676 $a620.19 700 $aMaia$b F. Raquel$01749454 701 $aOliveira$b J. Miguel$01749455 701 $aReis$b Rui L$01290163 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910874670703321 996 $aHandbook of the Extracellular Matrix$94183685 997 $aUNINA