LEADER 04974nam 22007215 450 001 9910874669703321 005 20250808093307.0 010 $a3-031-61257-4 024 7 $a10.1007/978-3-031-61257-2 035 $a(MiAaPQ)EBC31545393 035 $a(Au-PeEL)EBL31545393 035 $a(CKB)33329735200041 035 $a(DE-He213)978-3-031-61257-2 035 $a(EXLCZ)9933329735200041 100 $a20240723d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAging $eHow Science Works /$fby Carsten Carlberg, Stine M. Ulven, Eunike Velleuer 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (184 pages) 311 08$a3-031-61259-0 311 08$a3-031-61256-6 327 $a1. The human genome, development and evolution -- 2. Gene expression and epigenetics -- 3. Epigenetics and aging -- 4. Molecular and cellular basis of aging -- 5. Nutrition and aging -- 6. Aging and immunity -- 7. Central role of aging during chronic diseases -- 8. Aging and cancer -- 9. Healthy aging. 330 $aAging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get. The process of aging limits our maximal life span, which is for our humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells. We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer. We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says ?Teach us to number our days, that we may get a heart of wisdom.? It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have. . 606 $aMolecular biology 606 $aEpigenetics 606 $aNutrition 606 $aMolecular evolution 606 $aCancer 606 $aMetabolism 606 $aMolecular Biology 606 $aEpigenetics 606 $aNutrition 606 $aMolecular Evolution 606 $aCancer Biology 606 $aMetabolism 615 0$aMolecular biology. 615 0$aEpigenetics. 615 0$aNutrition. 615 0$aMolecular evolution. 615 0$aCancer. 615 0$aMetabolism. 615 14$aMolecular Biology. 615 24$aEpigenetics. 615 24$aNutrition. 615 24$aMolecular Evolution. 615 24$aCancer Biology. 615 24$aMetabolism. 676 $a572 700 $aCarlberg$b Carsten$0849346 701 $aUlven$b Stine M$01749432 701 $aVelleuer$b Eunike$01733291 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910874669703321 996 $aAging$94183675 997 $aUNINA