LEADER 05021nam 2200625 450 001 9910829867903321 005 20170816111606.0 010 $a1-281-94695-8 010 $a9786611946951 010 $a3-527-62262-4 010 $a3-527-62263-2 035 $a(CKB)1000000000556925 035 $a(EBL)482165 035 $a(OCoLC)264621059 035 $a(SSID)ssj0000107000 035 $a(PQKBManifestationID)11133718 035 $a(PQKBTitleCode)TC0000107000 035 $a(PQKBWorkID)10006041 035 $a(PQKB)11313761 035 $a(MiAaPQ)EBC482165 035 $a(PPN)190790784 035 $a(EXLCZ)991000000000556925 100 $a20160819h20082008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAsymmetric phase transfer catalysis /$fedited by Keiji Maruoka 210 1$aWeinheim, [Germany] :$cWiley-VCH Verlag GmbH & Co. KGaA,$d2008. 210 4$dİ2008 215 $a1 online resource (230 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31842-9 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aAsymmetric Phase Transfer Catalysis; Contents; Preface; List of Contributors; 1 The Basic Principle of Phase-Transfer Catalysis and Some Mechanistic Aspects; 1.1 Introduction; 1.2 Inorganic Base-Promoted Activation of Acidic Organic Compounds; 1.2.1 Generation of Reactive Onium Carbanion Species; 1.2.2 Stability of the Onium Carbanion; 1.2.3 Reactivity of the Onium Carbanion; 1.2.4 Nuclueophilic Substitution Reaction; 1.2.5 Nucleophilic Addition to Electrophilic C=X Double Bonds; 1.3 Phase-Transfer-Catalyzed Addition of Anion Supplied as Metal Salt 327 $a1.4 Use of Crown Ether as Phase-Transfer CatalystReferences; 2 Cinchona-Derived Chiral Phase-Transfer Catalysts for Amino Acid Synthesis; 2.1 Introduction; 2.2 ?-Amino Acid Synthesis; 2.2.1 Monoalkylation of Schiff Bases Derived from Glycine; 2.2.2 Alkylation of Schiff Bases Derived from ?-Alkyl-?-Amino Acids; 2.2.3 Other Alkylations for ?-Amino Acid Synthesis; 2.2.4 Michael Reaction of Glycinate Benzophenone Schiff Bases; 2.2.5 Aldol and Related Reactions; 2.2.6 Aza-Henry Reaction; 2.2.7 Strecker Reaction; 2.2.8 Aziridination; 2.2.9 Radical Reaction; 2.3 ?-Amino Acid Synthesis 327 $a2.3.1 Mannich Reaction2.3.2 Cyclopropanation; 2.4 Conclusions; References; 3 Cinchona-Derived Chiral Phase-Transfer Catalysts for Other Asymmetric Synthesis; 3.1 Introduction; 3.2 Asymmetric Darzens Reaction; 3.3 Asymmetric Conjugated Addition; 3.4 Asymmetric Aldol Reaction; 3.5 Asymmetric Oxygen-Functionalization; 3.6 Asymmetric Alkylation; 3.7 Asymmetric Alkenylation and Alkynylation; 3.8 Asymmetric S(N) Aromatic Reaction; 3.9 Asymmetric Strecker Synthesis; 3.10 Asymmetric Fluorination; References; 4 Cinchona-Derived Chiral Poly(Phase-Transfer Catalysts) for Asymmetric Synthesis 327 $a4.1 Cinchona Alkaloids4.1.1 Cinchona Alkaloids in Asymmetric Phase-Transfer Catalysis; 4.1.2 The Origin of Stereoselectivity of Cinchona-PTCs; 4.2 Development of Dimeric Cinchona-PTCs by the Park-Jew Group; 4.2.1 Dimeric Cinchona-PTCs with Phenyl Linker; 4.2.2 1,3-Dimeric Cinchona-PTCs with Electronically Modified Phenyl Linker; 4.2.3 Polymeric Cinchona-PTCs with Other Linkers; 4.2.4 1,3-Phenyl- and 2,7-Naphthyl-Linked Dimeric Cinchona-PTCs; 4.3 Polymeric PTCs Developed by the Najera Group; 4.4 Polymeric PTCs Developed by the Siva Group; 4.5 Polymeric PTCs Developed by the Wang Group 327 $a4.6 Asymmetric Epoxidation with Polymeric Cinchona-PTCs4.7 Conclusions; References; 5 Binaphthyl- and Biphenyl-Modified Chiral Phase-Transfer Catalysts for Asymmetric Synthesis; 5.1 Introduction; 5.2 Alkylation; 5.2.1 Asymmetric Synthesis of ?-Alkyl ?-Amino Acids and Their Derivatives; 5.2.1.1 Asymmetric Monoalkylation of Glycine Ester Schiff Bases; 5.2.1.2 Asymmetric Monoalkylation of Glycine Amide Schiff Bases; 5.2.1.3 Diastereoselective Alkylation of Glycine Schiff Base with Optically Enriched Alkyl Halides; 5.2.1.4 Recyclable Catalysts and Reagents and Solid-Phase Synthesis 327 $a5.2.1.5 Application of Asymmetric Synthesis of ?-Amino Acids 330 $aEdited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable.A must for every synthetic chemist in academia and industry. 606 $aPhase-transfer catalysis 606 $aAsymmetry (Chemistry) 615 0$aPhase-transfer catalysis. 615 0$aAsymmetry (Chemistry) 676 $a547.215 702 $aMaruoka$b Keiji 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829867903321 996 $aAsymmetric phase transfer catalysis$94045938 997 $aUNINA LEADER 04122nam 22007455 450 001 9910869159203321 005 20250807135610.0 010 $a9783031254055 010 $a3031254058 024 7 $a10.1007/978-3-031-25405-5 035 $a(CKB)32609780700041 035 $a(MiAaPQ)EBC31507678 035 $a(Au-PeEL)EBL31507678 035 $a(DE-He213)978-3-031-25405-5 035 $a(MiAaPQ)EBC31574214 035 $a(Au-PeEL)EBL31574214 035 $a(EXLCZ)9932609780700041 100 $a20240629d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHistory of Rabies in the Americas: From the Pre-Columbian to the Present, Volume II $eHistorical Introductions and Disease Status To Date /$fedited by Charles E. Rupprecht 205 $a1st ed. 2024. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2024. 215 $a1 online resource (432 pages) 225 1 $aFascinating Life Sciences,$x2509-6753 311 08$a9783031254048 311 08$a303125404X 320 $aIncludes bibliographical references and index. 327 $a1. Rabies in Canada -- 2. Rabies in the USA -- 3. Rabies in Mexico -- 4. Rabies in the Caribbean -- 5. Rabies in Central America -- 6. Rabies in Colombia -- 7. Rabies in Brazil -- 8. Rabies in Venezuela -- 9. Rabies in Guyana, French Giana, and Suriname -- 10. Rabies in Chile -- 11. Rabies in Peru -- 12. Rabies in Ecuador -- 13. Rabies in Argentina -- 14. Rabies in Bolivia -- 15. Rabies in Paraguay -- 16. Rabies in Uruguay -- 17. Conclusions and future perspectives for the region -- 18. Afterword. 330 $aRabies is one of the oldest known pathogens, is incurable, and has the highest fatality rate of all infectious diseases. The Americas is the only region with bat rabies virus, including vampire bat rabies. The region is rich in cultural references and notable for many discoveries in the field, including the current vaccine potency test, diagnostic assay, conception of oral vaccines for wildlife, the first human survivor and the first successful canine rabies program executed at a broad level. Rabies remains the most important viral zoonosis, with tens of thousands of human fatalities and tens of millions of exposures annually, which can be used to model for other pathogens, such as COVID-19. There is an international effort to eliminate human rabies caused by dogs over the next decade, and the Americas represent the primary region with the greatest proof-of-concept evidence to accomplish this goal. This two-volume set addresses the medical history and modern results of rabies in countries throughout the Americas, including the implications of and on cultural, economic, sociological, and research developments in the region. Volume II provides an in-depth analysis of the rabies' presence and impact in specific countries, including historical perspectives, advances in research and understanding, and current status. . 410 0$aFascinating Life Sciences,$x2509-6753 606 $aImmunology 606 $aVirology 606 $aMedicine$xHistory 606 $aVeterinary medicine 606 $aVaccines$xBiotechnology 606 $aBiomaterials 606 $aImmunology 606 $aVirology 606 $aHistory of Medicine 606 $aVeterinary Science 606 $aBiomaterials-Vaccines 615 0$aImmunology. 615 0$aVirology. 615 0$aMedicine$xHistory. 615 0$aVeterinary medicine. 615 0$aVaccines$xBiotechnology. 615 0$aBiomaterials. 615 14$aImmunology. 615 24$aVirology. 615 24$aHistory of Medicine. 615 24$aVeterinary Science. 615 24$aBiomaterials-Vaccines. 676 $a616.953 702 $aRupprecht$b Charles E. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910869159203321 996 $aHistory of Rabies in the Americas: From the Pre-Columbian to the Present, Volume II$94430667 997 $aUNINA