LEADER 05180nam 2200601Ia 450 001 9910830923603321 005 20230829003002.0 010 $a1-280-85433-2 010 $a9786610854332 010 $a3-527-60803-6 010 $a3-527-60736-6 035 $a(CKB)1000000000377172 035 $a(EBL)482336 035 $a(OCoLC)70159059 035 $a(SSID)ssj0000261262 035 $a(PQKBManifestationID)11206105 035 $a(PQKBTitleCode)TC0000261262 035 $a(PQKBWorkID)10255485 035 $a(PQKB)10374377 035 $a(MiAaPQ)EBC482336 035 $a(EXLCZ)991000000000377172 100 $a20050106d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTranscription factors in the nervous system$b[electronic resource] $edevelopment, brain function and diseases /$fedited by Gerald Thiel 210 $aWeinheim $cWiley-VCH$dc2006 215 $a1 online resource (507 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31285-4 320 $aIncludes bibliographical references and index. 327 $aTranscription Factors in the Nervous System; Contents; Preface; List of Contributors; Color Plates; Part I Transcription Factors in Neural Development; 1 Roles of Hes bHLH Factors in Neural Development; 1.1 Introduction; 1.2 Structure and Transcriptional Activities of Hes Factors; 1.3 Regulation of Hes Gene Expression; 1.4 Expression of Hes Genes in the Developing Nervous System; 1.5 Maintenance of Neural Stem Cells by Hes Genes; 1.6 Promotion of Gliogenesis by Hes Genes; 1.7 Maintenance of the Isthmic Organizer by Hes Genes; 1.8 Perspective; Acknowledgments; Abbreviations 327 $a2 The Role of Pax6 in the Nervous System during Development and in Adulthood: Master Control Regulator or Modular Function?Abstract; 2.1 Introduction; 2.2 Molecular Features of Pax6; 2.2.1 The Paired Domain; 2.2.2 The Paired-Type Homeodomain; 2.2.3 Different Pax6 Isoforms; 2.2.4 Protein-Protein Interactions; 2.2.5 Post-Translational Modifications of Pax6; 2.3 Function of Pax6 in Development; 2.3.1 Function of Pax6 in the Developing Eye; 2.3.2 Function of Pax6 in the Developing Brain; 2.3.2.1 Telencephalon; 2.3.2.2 Diencephalon; 2.3.2.3 Cerebellum; 2.3.2.4 Spinal Cord 327 $a2.4 Function of Pax6 in the Adult Brain2.5 Mechanisms of Pax6 Function; 2.6 Conclusions and Outlook; Abbreviations; 3 Phox2a and Phox2b: Essential Transcription Factors for Neuron Specification and Differentiation; Abstract; 3.1 Introduction; 3.2 Molecular Characteristics of Phox2 Genes and Proteins; 3.2.1 Sequence and Gene Structure Conservation in the Animal Kingdom; 3.2.2 Transcriptional Activation by Phox2 Proteins; 3.3 Physiological Relevance of Phox2 Transcription Factors; 3.3.1 Expression Pattern; 3.3.2 Effects of Phox2 Gene Mutations 327 $a3.3.2.1 Autonomic Neural Crest Derivatives and Visceral Sensory Ganglia3.3.2.2 Central Noradrenergic Neurons; 3.3.2.3 Autonomic Centers in the Hindbrain; 3.3.3 Human Mutations; 3.4 Molecular Mechanism of Action in Different Lineages; 3.4.1 Sympathetic Neurons; 3.4.2 Parasympathetic Neurons; 3.4.3 Enteric Neurons; 3.4.4 Visceral Sensory Neurons of the Geniculate, Petrosal and Nodose Ganglia; 3.4.5 Central Noradrenergic Neurons; 3.4.6 Autonomic Centers in the Hindbrain; 3.4.6.1 Afferent Visceral Centers; 3.4.6.2 Efferent Visceral Centers; 3.4.7 Oculomotor (nIII) and Trochlear (nIV) Centers 327 $a3.5 Conclusions and Outlook3.5.1 Distinct or Identical Functions for Phox2a and Phox2b?; 3.5.2 Master Control Genes for Noradrenergic Differentiation; 3.5.3 Master Control Genes for Autonomic Reflex Circuit Generation; Acknowledgments; Abbreviations; 4 Functions of LIM-Homeodomain Proteins in the Development of the Nervous System; Abstract; 4.1 Introduction; 4.2 Common Structural Features and Classification of LIM-HD Proteins; 4.3 LIM-HD Proteins and the Development of Invertebrate Nervous Systems; 4.3.1 C. elegans; 4.3.2 Drosophila 327 $a4.4 Functions of LIM-HD Proteins in the Development of Vertebrate Nervous Systems 330 $aThis first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases.With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, ne 606 $aTranscription factors 606 $aNeural stem cells 615 0$aTranscription factors. 615 0$aNeural stem cells. 676 $a616.8042 701 $aThiel$b Gerald$01691120 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830923603321 996 $aTranscription factors in the nervous system$94067285 997 $aUNINA LEADER 04561nam 22006255 450 001 9910865232903321 005 20240628130857.0 010 $a9783658439743 024 7 $a10.1007/978-3-658-43974-3 035 $a(CKB)32200630800041 035 $a(MiAaPQ)EBC31360212 035 $a(Au-PeEL)EBL31360212 035 $a(DE-He213)978-3-658-43974-3 035 $a(OCoLC)1439025245 035 $a(EXLCZ)9932200630800041 100 $a20240531d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Path to Sustainable Corporate Management $eHow to Take Responsibility for People, the Environment and the Economy /$fby Ralf T. Kreutzer 205 $a1st ed. 2024. 210 1$aWiesbaden :$cSpringer Fachmedien Wiesbaden :$cImprint: Springer,$d2024. 215 $a1 online resource (316 pages) 225 0 $aBusiness and Management Series 311 08$a9783658439736 327 $aSustainability in corporate management, marketing and brand management -- Legal framework conditions and requirements for sustainability -- Integration of sustainability concepts into the purpose definition of companies -- Sustainability potential along the entire value chain -- Sustainability potential in marketing and brand management -- Don'ts in sustainable corporate management -- Monitoring and controlling to ensure sustainable corporate management -- Development of a "green journey" for your own company. 330 $aThis book shows how managers at all levels of the company can master the challenges of sustainable corporate management with confidence. Concrete action plans are presented for this purpose. Climate change and the finite nature of natural resources are already taking their toll worldwide. A rethink towards ecological sustainability is not only urgently needed at a global level. The orientation of corporate strategies is also increasingly determined by the socio-political morals of customers and other stakeholders, where economic and socio-political interests must be in harmony with social and ecological challenges. Using the three-pillar model for sustainability (Triple Bottom Line) and further topics (such as supply chain law and ESG criteria), the author shows in a practical way how companies can successfully meet these major challenges in the long term. The key to success lies in a change in values towards ecological, social and economic sustainability that is defined and practiced at all levels of the company. Nicola Oudejans, Course Director Chief Digital Officer at the University for Continuing Education Krems/Danube University Krems Prof. Dr. Ralf T. Kreutzer has been Professor of Marketing at the HWR Berlin School of Economics and Law as well as Marketing and Management Consultant since 2005. He spent 15 years in various management positions at Bertelsmann, Volkswagen and Deutsche Post before being appointed Professor of Marketing in 2005. Through regular publications and lectures, Prof. Kreutzer has provided significant impetus on various topics relating to marketing, dialog marketing, CRM/customer loyalty systems, database marketing, online marketing, social media marketing, digital Darwinism, strategic and international marketing, artificial intelligence, and has advised a large number of companies in Germany and abroad on these topics. Professor Kreutzer is a founding member of the consulting firm Green Elephant Consulting (www.green-elephant.info), which specializes in making sustainability feasible for companies. The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content. . 606 $aStrategic planning 606 $aLeadership 606 $aMarketing 606 $aBranding (Marketing) 606 $aSustainability 606 $aBusiness Strategy and Leadership 606 $aMarketing 606 $aBranding 606 $aSustainability 615 0$aStrategic planning. 615 0$aLeadership. 615 0$aMarketing. 615 0$aBranding (Marketing) 615 0$aSustainability. 615 14$aBusiness Strategy and Leadership. 615 24$aMarketing. 615 24$aBranding. 615 24$aSustainability. 676 $a658.4083 700 $aKreutzer$b Ralf$01253475 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910865232903321 996 $aThe Path to Sustainable Corporate Management$94464785 997 $aUNINA