LEADER 02826nam 22005895 450 001 9910863281403321 005 20251113203947.0 010 $a981-15-8807-4 024 7 $a10.1007/978-981-15-8807-5 035 $a(CKB)4100000011528337 035 $a(MiAaPQ)EBC6380987 035 $a(DE-He213)978-981-15-8807-5 035 $a(PPN)260301736 035 $a(EXLCZ)994100000011528337 100 $a20201028d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCircadian Pharmacokinetics /$fedited by Baojian Wu, Danyi Lu, Dong Dong 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2020. 215 $a1 online resource (VII, 253 p. 59 illus., 46 illus. in color.) 311 08$a981-15-8806-6 327 $aChapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy. 330 $aThis book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book. 606 $aPharmacology 606 $aPharmacy 606 $aMedical sciences 606 $aDrug development 606 $aPharmacology 606 $aPharmacy 606 $aPreclinical Research 615 0$aPharmacology. 615 0$aPharmacy. 615 0$aMedical sciences. 615 0$aDrug development. 615 14$aPharmacology. 615 24$aPharmacy. 615 24$aPreclinical Research. 676 $a780 702 $aWu$b Baojian 702 $aLu$b Danyi 702 $aDong$b Dong 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910863281403321 996 $aCircadian pharmacokinetics$92495865 997 $aUNINA