LEADER 04398nam 2200529 450 001 9910136805903321 005 20230808192403.0 035 $a(CKB)3710000000631086 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41045 035 $a(EXLCZ)993710000000631086 100 $a20160411c2016uuuu fy| 0 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aApplication of genetically encoded indicators to mammalian central nervous system$b[electronic resource] /$fedited by Yoshiyuki Yamada and Katsuhiko Mikoshiba 210 $cFrontiers Media SA$d2016 210 1$a[Place of publication not identified] :$cFrontiers Media SA,$d2016. 215 $a1 online resource (116 pages) $cillustrations; digital file(s) 225 0 $aFrontiers Journal series 225 1 $aFrontiers Research Topics,$x1664-8714 300 $a"Published in: Frontiers in molecular neuroscience" --front cover. 311 $a2-88919-804-9 320 $aIncludes bibliographical references. 327 $aEditorial: application of genetically encoded indicators to mammalian central nervous system --Monitoring activity in neural circuits with genetically encoded indicators --Putting a finishing touch on GECIs --Genetically encoded CaČ? indicators; expanded affinity range, color hue and compatibility with optogenetics --Investigating neuronal function with optically controllable proteins --Exploration of genetically encoded voltage indicators based on a chimeric voltage sensing domain --Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane --Imaging activity in astrocytes and neurones with genetically encoded calcium indicators following in utero electroporation --Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse --Wide-field CaČ? imaging reveals visually evoked activity in the retrosplenial area --Habituation of glomerular responses in the olfactory bulb following prolonged odor stimulation reflects reduced peripheral input. 330 3 $aGenetically encoded indicators emerged as promising tools for cell type-specific and chronic recording of neuronal population activity. Since publication of the first prototypical genetically encoded Ca2+ indicators (Cameleons) in 1997, we have witnessed remarkable evolution of the field, with rapid improvement of indicator performance as well as expanded application to many model organisms in the neuroscience community. Challenges still remain, however, concerning the mammalian central nervous system: limited sensitivity of indicators to subtle changes in activity, slow signal kinetics, cytotoxicity after a long-term and high-level expression of indicators, and variable performance across cell types. In addition to improvement of the indicators per se, development of strategies that allow combined use of the indicators and optogenetic tools is also desired. In this Research Topic, we recruited top researchers in the field and their young colleagues to present their cutting-edge research as well as insightful opinions on the following subtopics:1) Latest breakthroughs on development of genetically encoded indicators2) Novel scientific findings obtained with genetically encoded indicators3) Wishlist for the next-generation genetically encoded indicators4) Guideline for selecting an appropriate indicator5) Optimal methodology for indicator delivery to mammalian CNS. 410 0$aFrontiers Research Topics,$x1664-8714 606 $aNeurosciences 606 $aNeurosciences$xResearch 606 $aNeuropsychiatry$xResearch 610 $ain vivo imaging 610 $aGenetically encoded calcium indicators (GECIs) 610 $agenetically encoded voltage sensor 610 $aFluorescent protein sensors 610 $agenetically encoded sensors 615 0$aNeurosciences. 615 0$aNeurosciences$xResearch. 615 0$aNeuropsychiatry$xResearch. 700 $aYoshiyuki Yamada$4auth$01376542 702 $aYamada$b Yoshiyuki 702 $aMikoshiba$b Katsuhiko$f1945- 801 2$bUkMaJRU 906 $aBOOK 912 $a9910136805903321 996 $aApplication of genetically encoded indicators to mammalian central nervous system$93412437 997 $aUNINA LEADER 04808nam 22005655 450 001 9910863199503321 005 20250610110206.0 010 $a9783030530327 010 $a3030530329 024 7 $a10.1007/978-3-030-53032-7 035 $a(CKB)4100000011515581 035 $a(MiAaPQ)EBC6381283 035 $a(DE-He213)978-3-030-53032-7 035 $a(Perlego)3481888 035 $a(MiAaPQ)EBC29090455 035 $a(EXLCZ)994100000011515581 100 $a20201024d2021 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMarshall and the Marshallian Heritage $eEssays in Honour of Tiziano Raffaelli /$fedited by Katia Caldari, Marco Dardi, Steven G. Medema 205 $a1st ed. 2021. 210 1$aCham :$cSpringer International Publishing :$cImprint: Palgrave Macmillan,$d2021. 215 $a1 online resource (XXIII, 286 p. 7 illus., 2 illus. in color.) 225 1 $aPalgrave Studies in the History of Economic Thought,$x2662-6586 300 $aIncludes index. 311 08$a9783030530310 311 08$a3030530310 327 $aForeword -- Part One: Revisiting Marshall's Economics -- 1. Alfred Marshall in the Lower Valdarno -- 2. The organization of knowledge and knowledge as organization -- 3.Raffaelli on historical progress in Smith and in Marshall -- 4. Marshall's external economies. Economic evolution and patterns of development -- 5.Economic, Ethical and Political Aspects of Wellbeing. Marshallian Insights from his Book on Progress -- 6. Jevons and Marshall as Humboldtian scientists -- 7. Utilitarianism, the Moral Sciences, and Political Economy -- Part Two: Marshall's Influence Through the 20th Century -- 8. Destabilizing speculation on organized markets. Early perspectives in the spirit of Marshall -- 9. Industrial leadership, market power and long-term performance. Marshall's and Keynes's appreciation of American trusts -- 10. Between LSE and Cambridge. Accounting for Ronald Coase's fascination with Alfred Marshall -- 11. "A great economist" and "a careful empiricist". Paul Samuelson's attitude towards Alfred Marshall. 330 $aTiziano Raffaelli (Pisa 1950) was a widely esteemed scholar in the field of the history and methodology of economics, who died suddenly in January 2016 while still in the midst of working and of developing projects for new lines of research. He was a philosopher of science by formation and a historian of economic ideas by professional choice, with interests covering a vast area, ranging from the 18th to the 20th century and from Europe to the US. Where he left an indelible mark, however, was in his interpretation of Alfred Marshall's economic theory and its reverberations through Keynes on the one hand, and the Cambridge school of industrial economics on the other. Raffaelli's research in this field offered a completely new view of the core and meaning of Marshall's work and of its relevance for 21st century social scientists. In the process, it stimulated a new and fruitful research program in Marshallian economics. This volume consists of two parts. Thefirst is devoted to illustrating the above-mentioned changes in the understanding of Marshallian economics and Raffaelli's role in bringing them about. The second part offers a collection of essays documenting some more recent developments in fields related to Marshall and his influence, including welfare economics and industrial organization, Marshall's legacy in Cambridge economics, the Chicago school, and beyond. The contributors to this volume range from leading senior scholars in the field to exceptional young scholars, and their contributions illustrates a myriad of ways in which the "new view" of Marshall inspired by Raffaelli's work influences our understanding of the history of economics from the late 19th century onward. This book will be of international interest to scholars working in the history of economic thought, and will also appeal to philosophers of science, methodologists, intellectual historians, and those who specialize in industrial organisation. . 410 0$aPalgrave Studies in the History of Economic Thought,$x2662-6586 606 $aEconomics$xHistory 606 $aHistory of Economic Thought and Methodology 615 0$aEconomics$xHistory. 615 14$aHistory of Economic Thought and Methodology. 676 $a330.157092 676 $a330.157092 700 $aCaldari$b Katia$0424049 702 $aMedema$b Steven G. 702 $aDardi$b Marco 702 $aCaldari$b Katia 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910863199503321 996 $aMarshall and the Marshallian Heritage$94332297 997 $aUNINA