LEADER 04154nam 22006855 450 001 9910863189903321 005 20250610110429.0 010 $a3-030-54077-4 024 7 $a10.1007/978-3-030-54077-7 035 $a(CKB)4100000011413891 035 $a(DE-He213)978-3-030-54077-7 035 $a(MiAaPQ)EBC6335302 035 $a(PPN)250221519 035 $a(MiAaPQ)EBC29092730 035 $a(EXLCZ)994100000011413891 100 $a20200902d2020 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPalladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles /$fby Hyung Yoon 205 $a1st ed. 2020. 210 $cSpringer International Publishing$d2020 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XXIX, 212 p. 552 illus., 35 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 08$a3-030-54076-6 327 $aChapter 1. Carbohalogenation Catalyzed by Palladium and Nickel -- Chapter 2. Diastereoselective Pd-Catalyzed Aryl Cyanation and Aryl Borylation -- Chapter 3. Pd-Catalyzed Spirocyclization via C?H Activation and Benzyne/Alkyne Insertion. 330 $aThis book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon?carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C?H activation and ?-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aCatalysis 606 $aChemistry, Inorganic 606 $aChemistry, Organic 606 $aOrganometallic chemistry 606 $aChemistry, Physical and theoretical 606 $aCatalysis$3https://scigraph.springernature.com/ontologies/product-market-codes/C29000 606 $aInorganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C16008 606 $aOrganic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19007 606 $aOrganometallic Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C19020 606 $aPhysical Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C21001 615 0$aCatalysis. 615 0$aChemistry, Inorganic. 615 0$aChemistry, Organic. 615 0$aOrganometallic chemistry. 615 0$aChemistry, Physical and theoretical. 615 14$aCatalysis. 615 24$aInorganic Chemistry. 615 24$aOrganic Chemistry. 615 24$aOrganometallic Chemistry. 615 24$aPhysical Chemistry. 676 $a541.395 700 $aYoon$b Hyung$4aut$4http://id.loc.gov/vocabulary/relators/aut$01065403 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910863189903321 996 $aPalladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles$92545056 997 $aUNINA