LEADER 04512nam 22006735 450 001 9910863153903321 005 20250325165636.0 010 $a9783030578145 010 $a3030578143 024 7 $a10.1007/978-3-030-57814-5 035 $a(CKB)4100000011569211 035 $a(DE-He213)978-3-030-57814-5 035 $a(MiAaPQ)EBC6387589 035 $a(PPN)252510240 035 $a(EXLCZ)994100000011569211 100 $a20201109d2020 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Science and Business of Drug Discovery $eDemystifying the Jargon /$fby Edward D. Zanders 205 $a2nd ed. 2020. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020. 215 $a1 online resource (XVII, 402 p. 102 illus., 20 illus. in color.) 311 08$a9783030578138 311 08$a3030578135 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline ? discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline ? clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters. 330 $aThe Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry ofsmall and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators . 606 $aPharmacology 606 $aPharmacovigilance 606 $aPharmaceutical chemistry 606 $aChemistry, Physical and theoretical 606 $aBiotechnology 606 $aPharmacology 606 $aDrug Safety and Pharmacovigilance 606 $aPharmaceutics 606 $aTheoretical Chemistry 606 $aBiotechnology 615 0$aPharmacology. 615 0$aPharmacovigilance. 615 0$aPharmaceutical chemistry. 615 0$aChemistry, Physical and theoretical. 615 0$aBiotechnology. 615 14$aPharmacology. 615 24$aDrug Safety and Pharmacovigilance. 615 24$aPharmaceutics. 615 24$aTheoretical Chemistry. 615 24$aBiotechnology. 676 $a615.19 700 $aZanders$b Edward D.$0511858 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910863153903321 996 $aThe science and business of drug discovery$93562757 997 $aUNINA